1. #Ebola thread.
#DRC has declared a new #Ebola outbreak after diagnosing the disease in a 31 yo man who died in Mbandaka in NW DRC. This is across the country from the terrible North Kivu-Ituri outbreak that raged from 2018-2020.
afro.who.int/countries/demo…
2. The man began experiencing symptoms on April 5 but only ended up in an #Ebola treatment unit on April 21. That means there were probably unsafe exposures during that time. Or as @MoetiTshidi put it: "The disease has had a two-week head start and we are now playing catch-up."
3. On the positive side: at the #Ebola treatment unit, staff recognized what they were dealing with & were protected. The man was given a safe burial.
And there are a lot of people in Mbandaka & surrounding region who have been vaccinated with the Merck Ebola vaccine. #DRC
4. This is the 3rd #Ebola outbreak in this part of #DRC in the past 4 years. In 2018, there was an outbreak at Bikoro, but some cases ended up in Mbandaka, a city of over 1M people. That outbreak saw 54 cases & 33 deaths. Vaccine was used.
(Map from @cdcgov)
5. In 2020, there was an outbreak at Mbandaka that was declared in June & over by Nov. There were 130 cases & 55 deaths & again, vaccine was used.
That outbreak seemed to be caused both by a new spillover from animals & cases linked to the 2018 event. (Screenshot source: @cdcgov)
6. Given the location, either viral source could be at play here. There is clearly a natural reservoir for #Ebola in this part of #DRC. There are also survivors who could be harboring virus still.
DRC has supplies of the Merck vaccine & will begin vaccinating soon.
7. #DRC's health minister says 74 contacts of the man who died from #Ebola have been identified and will be monitored for symptoms.

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More from @HelenBranswell

Apr 25
1. This was fast! Genetic sequencing of #Ebola viruses collected from a man in NW #DRC who died on April 21 reveals that this is a new spillover event, not resurgence of activity from earlier outbreaks in this part of DRC.
The sequencing was done at @inrb_kinshasa.
Short 🧵 Image
2. In the past getting an answer to this would have taken a lot more time. Impressive to see how quickly this question was answered.
The sequencing information was contained in a report that discloses important details about this new #Ebola case. virological.org/t/april-2022-e…
3. The man who died of #Ebola on April 21 in Mbandaka was vaccinated against Ebola in 2020 during an earlier outbreak there.
The main purpose of the Merck Ebola vaccine is to extinguish outbreaks. Questions remain about how long it protects. This is n=1, but 😟.
Read 6 tweets
Apr 22
1. A short #flu thread.
@CDCgov's latest flu report, for the week ending April 16, shows flu chugging along pretty much at levels seen over the past number of weeks. A bit surprising it isn't dropping off by now, but flu in the time of Covid is even more unpredictable than usual.
2. Three more pediatric #flu deaths were reported to @CDCgov last week. They occurred in late Jan., late Feb., and mid-March. (There's often a reporting delay.) This season 22 children have died from flu in the US.
3. The Covid pandemic has really disrupted #flu transmission; there was almost no flu in the winter of 2020-21 and very low rates this year.
In the US, virtually the only type of flu to have made it through the Covid bottleneck was H3N2.
Read 4 tweets
Apr 20
1. #ACIP, @CDCgov's vaccine advisory group, is meeting today to discuss Covid boosters. I'll be live tweeting.
I don't believe there are going to be any votes today, so no changes in current policy. This meeting will shed light, though, on how the committee sees 4th doses.
2. If there are no votes at today's #ACIP meeting, that will mean the current US position on 4th doses — people 50 and older & people who are immunocompromised "may" get a 4th dose if they wish — will remain in place. It will not transition to a "should" recommendation.
3. @CDCgov's Ruth Link Gelles is racing through a presentation on vaccine effectiveness. I'm not going to be able to tweet all of this. Too fast. Her slides are here.
cdc.gov/vaccines/acip/…
Read 35 tweets
Apr 15
1. It's Friday & @CDCgov has issued its latest FluView report, for the week ending April 9. A short thread.
There've been 3 more pediatric #flu deaths reported to CDC, bringing the season's total so far to 16. Far fewer than most years but still.... Image
2. #Flu activity increased nationally last week, as it has in several of the last recent weeks. Let's put that in perspective, though.
It's true there is more #influenza-like illness now (left) than in mid-February. (right) ImageImage
3. But there was more #flu-like illness in the last week of 2021. As it stands, the peak of flu activity in this very mild flu season was in the week between Christmas and New Years. Image
Read 4 tweets
Apr 15
1. ICYMI: The US is among a growing — though still small — list of countries reporting unusual cases of severe #hepatitis in young children. England, Scotland, Spain have also reported cases; Northern Ireland is investigating some possible cases. statnews.com/2022/04/14/u-s…
2. Severe #hepatitis is rare in young children & the usual suspects — the range of hepatitis viruses — have been ruled out in these cases.
In the US, Alabama has recorded 9 cases. There are likely cases elsewhere. Clinicians, if you know of cases, please let me know.
3. Add Ireland to the growing list of countries investigating unusual severe hepatitis cases in young children.
Read 4 tweets
Apr 13
1. The #Covid19 pandemic remains a public health emergency of international concern, @WHO DG @DrTedros says. The Emergency Committee that advises WHO on Covid met recently & concluded it is too soon to declare the emergency over.
2. @DrTedros said last week the number of #Covid19 deaths globally was the lowest since the early days of the pandemic. But the pandemic is not over.
3. Didier Houssin, chair of the @WHO #Covid19 Emergency Committee, said the decision not to end the PHEIC was unanimous. He said countries shouldn't let down their guard and should push on with vaccination efforts.
Read 7 tweets

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