When I look at $DNA, I see 2 companies with the #Synbio side and the #Biosecurity. I know many people dismiss the biosecurity which is over 50% of the current revenues. They mostly come from Covid screening. You got to think that a cut in funding will impact these sales.
In the long term, I think biosecurity is a key strategy as $DNA is one of the only companies working on solutions to a problem that is being completely ignored. The biggest threat to the global economy is now bioterrorism.
Although Biosecurity revenues in the near term might come under pressure, I think the need for them will grow over time. Not for just monitoring infectious disease, but as a security measure to our way of life.
This is one of my favorite parts of the $DNA story. If Covid taught us anything was its far easier for a invisible enemy to cross borders then it is for bad people.
The other side of the $DNA story is the #Synbio. This comes in 2 parts with the Codebase and the Foundry. The foundry is the lab capacity for creating and editing microbes. The codebase is the tech side with the database of all that genetic information on editing.
The scale and cost for Synthetic Biology are inversely proportional. As the scale grows, the cost comes down. This makes the application of Synbio more and more available to the masses. It offers a sustainable way for manufacturing ingredients.
I love the horizontal approach they are taking for the development of synbio. They focus just in the research and development. There is far too much expertise needed to try to go from lab to market. That leads to terrible inefficiency.
This is probably one of the biggest biotech stories in the market right now. It might seem expensive in the near term, but the potential is endless.
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The first segment is Synthetic Biology. This is what I call the Mail Order DNA business. Many companies need DNA for developing therapies like cell engineering or gene therapies. Many of these DNA strands can be synthesized for just a few cents per base.
This won't be a huge money maker as they can ship hundreds of thousands of DNA sequences a year for just a few dollars per. It is the back bone of their sales, and its still growing nicely. Its the cash cow that will fund the future developments which can be big winners.
I only got 2 companies for my play on Personalized Medicine. This is about using genetic information to develop better therapies for patients. The 2 companies I want to look at are $NVTA and $EXAI.
$EXAI is really exciting. Beside having an #AI based drug development platform, they also have a single cell biopsy program. They take a single cell from the tumor and sequence it.
This gives them the information on which patients will have the best responses from which drugs. This is about Pharmacogenomics. How different people respond differently to medications based on their genetics.
I am going to mention a few more #CRISPR companies that didn't meet my expectations to be in my portfolio. My next pick would actually be $VERV. I have some reservations on how much market share they could really capture in an extremely competitive space of Cholesterol.
$VERV has impressed me on the management front. There is noting I would bet on more then top notch management. A great CEO will make magic out of nothing. I think $VERV with base editing and a great CEO will be successful, I just don't know how successful.
Then comes $CRSP which use to be my first and only #CRISPR company. I completely changes on this company. They have a great SCD program what will be successful, but it ends there.
My 3rd #CRISPR company has to be $CRBU, even though, I count them in my cell therapies space. They are not focused on any in-vivo editing at this time. They are completely focused on cell therapies around CAR-T and NK cells.
They are using the CAS9 and CAS12 enzymes along with their own unique guide called chRDNA. This uses a combination of RNA and DNA in the guide to increase binding affinity and better editing.
Their early data this week for CAR-T was impressive. It is still very early and clearly PD-1 will not be the "be all to end all". There are a lot of challenges to allogeneic CAR-T that need to be solved.
My second pick for #CRISPR is $NTLA. I know they are on the losing side of the patent dispute. We still don't know what if any impact that will have. They do have a great management team that is building a great company.
They are using first generation CAS9 editing in-vivo in the liver and for ex-vivo for cell therapies. They are also developing their own base editing program. They are still ambitious and chasing innovation. That is what gets my vote.
They have best in class data in their early ATTR program in phase 1. Its got a long way to go, but could be a huge success if this data continues. They have about $1 billion in cash to get them through this bear market in biotech.
$BEAM is my top pick in the #CRISPR space. They have base editing which solves many of the issues with the first generation editors. They still have the CAS12 if they need it to do any cell editing in their cell therapies.
All their tech licenses comes from the winning side of the patent dispute which makes them safe. They have a great management team. They also have $1.2 billion in cash which will last them a long time in this bear market.
They are just entering the clinic this year so it will all come down to the data. Their preclinical data seemed superior to that of $CRSP at the same stage of development.