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1/ Now for a thread from the first author on the #LEM Paper:
👉What it IS
👉What it ISN'T
👉👉and What's NEXT...
doi.org/10.3390/metabo…
Read on... @realDaveFeldman
1/ Now for a thread from the first author on the #LEM Paper:
👉What it IS
👉What it ISN'T
👉👉and What's NEXT...
doi.org/10.3390/metabo…
Read on... @realDaveFeldman
https://twitter.com/realDaveFeldman/status/1527583710664527872
2/ What it IS:
We provide the first description of the long-awaited #LEM hypothesis, a model that attempts to explain:
(i) the inverse association between BMI and LDL-C on #lowcarb diets
(ii) the #LMHR phenotype, in which lean people on low carb exhibit very ⬆️LDL-C⬆️HDL-C⬇️TG
We provide the first description of the long-awaited #LEM hypothesis, a model that attempts to explain:
(i) the inverse association between BMI and LDL-C on #lowcarb diets
(ii) the #LMHR phenotype, in which lean people on low carb exhibit very ⬆️LDL-C⬆️HDL-C⬇️TG
3/ These phenomena, presently, have no complete competing explanation:
If effect were purely genetic, the🧬s would need 2explain:
>how macronutrient change can alter, not just LDL-C, but HDL-C+TG as part of a triad
>correlation between BMI and lipid changes
That's a tall order
If effect were purely genetic, the🧬s would need 2explain:
>how macronutrient change can alter, not just LDL-C, but HDL-C+TG as part of a triad
>correlation between BMI and lipid changes
That's a tall order
4/ If the effect were driven saturated fat intake, then one would necessarily be proposing leaner people eating low carb preferentially eat higher sat fat diets on a BMI continuum, and/or that sat fat is causally associated with leanness. Seems unlikely pubmed.ncbi.nlm.nih.gov/35498420/
5/ If #LMHR were driven by a hyper absorption phenomenon, baseline LDL-C in a cohort of LMHR would probably be elevated relative to non-LMHR, which is not the case. Also, cholesterol reduction would attenuate the phenotype. Again, not what's observed.
6/ The point is that, now, the #LEM provides the only complete mechanistic description of the inverse association between BMI and LDL-C change on low carb, and for LMHR
It is a HYPOTHESIS, but one that provides direct and testable predictions to guide future research.
It is a HYPOTHESIS, but one that provides direct and testable predictions to guide future research.
7/ What is ISN'T
👉 Not a proven model
👉 Not a value judgement on LMHR
👉 Not a comment on ASCVD risk
(NB: Sometimes this is missed in the twitter-verse, and misrepresentation of the science hinders future progress. We need to state what we know and what we don't.)
👉 Not a proven model
👉 Not a value judgement on LMHR
👉 Not a comment on ASCVD risk
(NB: Sometimes this is missed in the twitter-verse, and misrepresentation of the science hinders future progress. We need to state what we know and what we don't.)
8/ What's NEXT...
The #LEM has been a long time coming. Now that it's here, things are going to accelerate. Next up, we need to put the model to the test. Check out page 11 of the paper for our starter pack wish list of experiments!
mdpi.com/2218-1989/12/5…
The #LEM has been a long time coming. Now that it's here, things are going to accelerate. Next up, we need to put the model to the test. Check out page 11 of the paper for our starter pack wish list of experiments!
mdpi.com/2218-1989/12/5…
9/ Finally, incredibly grateful 4this team of awesome humans&scientists: @AdrianSotoMota, @bobkaplan,
@davidludwigmd, @BudoffMd, Anatol Kontush, and of course... the (in?)famous @realDaveFeldman
If you haven't seen his video abstract, thank me in 5 min
@davidludwigmd, @BudoffMd, Anatol Kontush, and of course... the (in?)famous @realDaveFeldman
If you haven't seen his video abstract, thank me in 5 min
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