Discover and read the best of Twitter Threads about #metabolism

Most recents (24)

We're proud to announce—the 10 #ETHNewYork Finalists! 🏆

⚔️ Guidl
🔥 Burn My Wallet
🐟 Tsukiji
🦺 NFT Safe Launch
🦪 Pearl
♨️ Steam tokenizer
🎶 Reverb
🔗 MeshLink
🔒 SafeNode
⚛️ ETHDos

👇/🧵
⚔️ Guidl

Guildl is a guild management platform for sharing player accounts and assets across the Web3 gaming ecosystem.

@tonyddattolo, @tobou, @tanzealous @j0xseph

showcase.ethglobal.com/ethnewyork2022…
🔥 Burn My Wallet

Burn My Wallet reports your hacked wallet as burnt 🔥 by minting a soul bound (non-transferrable) 🪙 token.

@erinleelikes, @NikitaVarabei

showcase.ethglobal.com/ethnewyork2022…
Read 15 tweets
Now we'll talk #polyphenols and #PrecisionNutrition in this next science packed session at #Nutrition2022. #NutritionLiveOnline Image
Oh look the #microbiome is here too! 🥰👏🥳 Yes, polyphenols are key to the #GutMicrobiome. Let's learn more.
#Nutrition2022 #NutritionLiveOnline Image
But first the #metabolome and polyphenols. #Nutrition2022 #NutritionLiveOnline Image
Read 12 tweets
New publication 🚨 Our RCT + isotope tracing detailing a significant nutrient-nutrient interaction during pregnancy between choline and docosahexaenoic acid (DHA; omega 3) is now online @AJCNutrition. A thread ⬇️
academic.oup.com/ajcn/advance-a… #RDchat #Metabolism #Obgyn #obstetrics
Nice write up of our trial from @NutraUSA! nutraingredients-usa.com/Article/2022/0…
Read 3 tweets
1/ Ex-type 2 diabetic - and my bud JJJ - sharing how he dropped HbA1c from 12 to 5.5 in 6 months on #Keto and came off meds at a patient panel for med students. Loving life, eating well! @minhal_ahmed @goutamgadiraju @MarkCzeisler @camitussie #metabolism #diabetes #foodismedicine
2/ Want to thank @ChrisPalmerMD @DoctorTro @BrianLenzkes @LowCarbEyeDoc @russwinn66 @StickmanBleedin @BiggestComeback for sharing as well. I believe @LCMDPodcast may release the full recording at some point. Also, want to thank my amazing peers for expressing interest in using
3/ Lifestyle and proper human nutrition to reverse metabolic disease. I know how hard we all work at school and that this is an above and beyond effort and I'm so appreciative that I'm not alone in being passionate about actually addressing the root causes of disease...
Read 4 tweets
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists 🇺🇸🇪🇺🇬🇧🇨🇦. Past programs still eligible for credit are at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
Read 48 tweets
#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner. amazon.com/Liposomal-Meth…
#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA) amazon.com/3Care-Concentr…
Read 93 tweets
So excited to finally share our paper, now available as a #bioRxiv preprint!

We found that enhancing #mtDNA replication can be highly deleterious, causing #Ferroptosis and neonatal 🫀#HeartDisease. 🧵thread coming soon..

biorxiv.org/content/10.110…

#newpublication #mitochondria
This project would not have been possible without the fantastic work from many people, so thank you all! @ASW_lab, @Kivela_lab, @WickstromLab, @JMitophile, @AWartiovaara et twitterless al.
@HelsinkiUniMed @helsinkiuni @HelsinkiUniMed @MitoResearch @uniofjyvaskyla @UniEastFinland
Recent years have brought several promising approaches to treat different kinds of #mitochondrial dysfunction, and increasing #mtDNA amount has been proposed to be beneficial for certain defects.
Read 11 tweets
What is NAD+? 💥
Part 1 of 3
#MedEd #MedTwitter #FOAMed #NAD #metabolism
Part 2 of 3
Part 3 of 3
Read 4 tweets
@kimisgubbed @VirusesImmunity @KaminskiMed @Be_Kinderr @jenbrea @ahandvanish Hey! Well hypoxic tissue cld lead to lower O2 extraction, & infected tissue is often hypoxic. Most intracellular pathogens hijack metabolism of cells they infect & “push” host mitochondrial metabolism to anerobic glycolysis (O2 not being used for OXPHOS): ij.hapres.com/htmls/IJ_1341_…
@kimisgubbed @VirusesImmunity @KaminskiMed @Be_Kinderr @jenbrea @ahandvanish 2/ In fact many intracellular #pathogens either directly or indirectly enhance hypoxia inducible factor (HIF-1) stability. HIF-1 is a key glycolytic regulator/transcription factor whose stability reduces reliance on OXPHOS by initiating glycolytic #metabolism
@kimisgubbed @VirusesImmunity @KaminskiMed @Be_Kinderr @jenbrea @ahandvanish 3/ With that in mind @VirusesImmunity, it was interesting that in your brain organoid model, you showed SARS-CoV-2 capable of infecting neurons, where it induced a locally hypoxic environment as measured by staining for HIF-1 alpha: pubmed.ncbi.nlm.nih.gov/33433624/
Read 11 tweets
ما هو #الخرف؟

هل هو مجرد نسيان؟

هل #الزهايمر هو ذاته الخرف؟

وهل يتم تشخيصه بتحاليل/أشعة طبية؟

هنالك الكثير من الخلط بما يخص الخرف بلا شك المختصين لهم دور فيه حيث تم تغيير مسمياته عدة مرات اخرها في ٢٠١٣.

سنجيب عن هذه التساؤلات في هذه السلسلة @CogNeuroKSA @SaudiAlZheimer ١/١٢
الخرف #dementia مسمى يصف مجموعة من أمراض الانتكاس العصبي والزهايمر احدى انواعه

يتصف بتدهور عقلي ليس فقط بالذاكرة ولكن قد يؤثر على التفكير والسلوك والقدرة على أداء الأنشطة اليومية

على الرغم من أن الخرف يؤثر بشكل أساسي على كبار السن إلا إنه ليس جزءًا طبيعيًا من كبر السن. ٢/١٢
يصيب الخرف ٢٠٪ من الأشخاص فوق ٨٠ سنة، و ٤٠٪ من هم بعمر ٨٥ سنة وأكبر

بفضل الله ثم تطورات الطب الحديث ازداد عدد السكان بعمر٨٠ وما فوق من ١٪ في ١٩٠٠م إلى ٤٪ من إجمالي عدد سكان العالم حالياً،

وبذلك ارتفعت عدد إصابات الخرف اليوم الى ٥٥ مليون والمتوقع ان تصل ١٣٩ مليون في ٢٠٥٠م

٣/١٢
Read 15 tweets
Now we're up to Ron Davis and the metabolic trap hypothesis for #MECFS: yeast model for the metabolic trap. (1/7) #metabolism #fatigue
Tryptophan is largely metabolized by a protein made by an enzyme called IDO-1. A second enzyme, called IDO-2, may be a "more primitive" version of the same enzyme. IDO-1 is substrate-inhibited. (2/7) #metabolism #MECFS
In a small study with ~20 severe patients, all had at least one mutation in IDO-2. "It's not a requirement that you have a mutation in IDO-2" to have ME/CFS, says Davis. It doesn't rule out that mutations here can play a role. (3/7) #metabolism #MECFS
Read 9 tweets
Ian Lipkin, now: Lipkin is summarizing a number of different efforts associated with his research group. He is the first person at this conference that has mentioned how previous coronaviral outbreaks (SARS/MERS) have led to ME/CFS-like syndromes. (1/7) #LongCOVID #MEcfs #GWI
Talking about work at Centers, with shout-outs to each center as well as the nonprofits that have been involved, including our own @MEActNet. (Looking forward to sharing stuff re: this project soon!) (2/7) #MEcfs @Columbia_CII
Overall aims for the Collaborative Research Centers, funded by @NIH. (3/7) #fatigue #MEcfs
Read 8 tweets
Niveles elevados de glucosa en sangre (hiperglucemia) en pacientes con #COVID19

Abro 🧵👇🏼

1/15

#SARSCoV2 #Diabetes #Glucose
Primero algunos (4) conceptos:

1️⃣ Insulina

Es una pequeña proteína producida por el páncreas. Le indica a nuestras células que deben absorber la glucosa que les llega a través del torrente sanguíneo

2/15

#Insulin #pancreas #metabolism
2️⃣Adiponectina

La adiponectina es una hormona producida por las células que almacenan la grasa (adipocitos), tiene dos funciones principales: hacer que las células sean más sensibles ante la insulina, y...

3/15

#FatTissue #Endocrinology #Hormones
Read 16 tweets
1/ New Human study supports twin-cycle hypothesis of #diabetes … thread incoming!
#metabolism #insulinresistance

sciencedirect.com/science/articl…
2/ The twin cycle hypothesis postulates that accumulation of liver fat can drive diabetes in the following way: more liver fat promotes hepatic insulin resistance which increases gluconeogenesis and thus increases insulin to promote more de novo lipogenesis. Basically…
3/ Basically, more liver fat more insulin resistance more liver fat and so on. New human data provide support for the model. One of the key findings of the paper is that more liver fat = more de novo lipogenesis, creating specifically the saturated fat palmitic acid (PA)…
Read 14 tweets
Circulating levels of Lipoprotein Lipase inhibiting factor ANGPTL8 are associated with increased all-cause mortality and CVD risk .@DaveKeto Thoughts?
#metabolism #cvd #LEM
P.S. (ANGPTL8 aka "betatrophin" in the literature)
nature.com/articles/s4159…
cell.com/trends/endocri…
2/ Also, it's all very mechanistic, with ANGPTL4 vs. 3/8 being oppositely regualted by feeding and fasting in a tissue specific manner such that fasting decreases fat storage in adopicytes and feeding promotes it.

And, perhaps, unsuprislingly, the lipid metabolism is...
3/ w.r.t ANGPTLs (and specifically 4, which controls local LPL activity) is linked with glucose homeostasis...
Read 5 tweets
One of the urban myths of NAD metabolism is the idea that NAD+ is good, while NADH is bad. NAD+:NADH are a redox couple that differ by a hydride group (a proton with 2 electrons) /1
NAD+ picks up the hydride when small molecules are oxidized, forming NADH. NADH donates the electrons to generate ATP and/or heat at the inner mitochondrial membrane. NADH is also the source of electrons in ketone body formation and gluconeogenesis /2
Thus, ketogenesis and gluconeogenesis are run in a reducing environment while fuel oxidation to produce ATP and/or heat requires oxygen as the ultimate electron acceptor to maintain a high NAD+/NADH ratio /3
Read 5 tweets
Daily Bookmarks to GAVNet 04/26/2021 greeneracresvaluenetwork.wordpress.com/2021/04/26/dai…
The Attack of the Civilization State: Towards One World or Conflict among Civilizations? - Bruno MaBruno Maçães on YouTube



The Attack of the Civilization State

noemamag.com/the-attack-of-…

#WorldGovernance #CivilizationState #NationState #HumanAdvancement
The Alignment Problem: Machine Learning and Human Values - Carlos Gershenson

vermontcomplexsystems.org/events/talkboc…

#VirtualComplexSystems #DataScience #seminars
Read 10 tweets
Our latest paper from @LabMetabolism is out! 🧠🔥

"Changes in mitochondrial morphology modulate LPS-induced loss of #calcium homeostasis in BV-2 microglial cells"

#Metabolism #NeuroTwitter #ImmunoTwitter
1/11
link.springer.com/article/10.100…
This was @osvaldo_rpe's first publication and a pretty cool debut indeed!

Osvaldo is a brilliant scientist that I had the honor to co-advise. No doubt I learned from him way way more than I taught.

A well-deserved first-authorship for an undergraduate student! 👏
2/11
Go, go #mitochondria!

We already knew that microglial activation induces mitochondrial fragmentation and that mito morphology correlates with its Ca2+ uptake

But the influence of mito Ca2+ handling on #microglial activation was still unclear...
3/11
Read 11 tweets
Happy 2021! @MBVanElzakker and I are excited to share our new article published in #Immunometabolism: “Pathogens Hijack Host Cell Metabolism: Intracellular Infection as a Driver of the Warburg Effect in Cancer and Other Chronic Inflammatory Conditions”: ij.hapres.com/htmls/IJ_1341_…
2/ In the paper, we detail molecular mechanisms by which #viral, #bacterial, and #parasite intracellular pathogens can induce, or contribute to, a Warburg-like #metabolism in infected host cells in order to meet their own replication and nutritional needs.
3/ We also discuss how host defense towards #infection may impact cellular metabolic changes (including how #mitochondria can participate in the innate immune response towards infection)
Read 9 tweets
With 2020 almost over, it's time again to look back at some of the BEST in the #bone field: 🔝20 papers (+extras).

Happy to hear your input! Disclosure: fully subjective ranking!
@ASBMR @AcademyEcts @Osteoporosis_NL @osteoporosisNI @mmse30 @NatalieASims
#1 Atypical Femoral fractures @NEJM (Black DM et al.)
Risk reduces within months of @Bisphosphonate1 discontinuation. Benefit>risk in any group but less so in Asians and women <65yr
nejm.org/doi/10.1056/NE…
-side note- @ECTS_science very useful systematic review and recommendations for managing osteoporosis following AFFs.
ncbi.nlm.nih.gov/pmc/articles/P…

And oral BPs may not only reduce fractures but also cardiovascular events
pubmed.ncbi.nlm.nih.gov/32717068/
@Dr_BoAbrahamsen @prieto_alhambra
Read 24 tweets
This interesting study found that skeletal #muscle cells of #ME/CFS patients showed a decrease in oxidative phosphorylation (a metabolic pathway used by #mitochondria to generate #energy). In simple terms, that caused the cells to have a dysregulated #metabolism.
2/ Not mentioned in the paper, but important to consider, is that most well-studied #viral + bacterial #pathogens “hijack” the metabolism of the cells they infect in a manner that can result in decreased oxidative phosphorylation (or similar changes in cell energy pathways).
3/ In simples terms, these #pathogens “hijack” cell metabolism to “pull” substrates out of the human mitochondrial energy pathways...and use the substrates (lipids, fatty acids, amino acids) for their own #nutritional and replication purposes!
Read 6 tweets
Two weeks in my @Levels program and have a bunch of tests & thoughts I'll share later but this was too interesting not to share now. Ate 3 pieces of pizza for dinner just to see what it did to my glucose... #wearables #metabolicfitness #metabolism #DigitalHealth
Initial response was not bad (relatively) for the first 3 hours - even got a score of 8 from @Levels but then it got interesting. Glucose continued to bounce and stay high for the next 7 (!) hours, well into my sleep... ImageImage
Glucose finally came down around 1AM - my sleep was terrible that night & @ouraring showed my HRV finally started going up (good) and resting HR came down (also good) right around 1AM, same time the glucose leveled... ImageImage
Read 11 tweets
🎉CELEBRATION ALERT!! We reached 10K followers @NatureCancer - massive thank you to our wonderful community for the warm welcome! Given it is also 10 months of our online life, here are some of our best articles (although all are *fantastic*) #thread 1/n

#10atNatureCancer
January @NatureCancer: Nabel &co @SanofiUS develp #trispecific antibodies against CD3, CD28 and CD38, with preclinical efficacy and safety in humanized mice and NHPs 2/n

go.nature.com/30GlQyH
rdcu.be/b78Zr

#10atNatureCancer
February @NatureCancer: Golub and Co @broadinstitute develop PRISM, a tool for non-oncology drug repurposing in #cancer 3/n

go.nature.com/36zCxQh
rdcu.be/b78ZE

#10atNatureCancer
Read 12 tweets

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