Eric Topol Profile picture
May 25 4 tweets 3 min read
Just out @NatureMedicine
The natural history of post-vaccine breakthrough infections (BTI) in 33,000 people, >13 million controls
nature.com/articles/s4159…
@zalaly @BCBowe @Biostayan @WUSTLmed
—Vaccination protection from #LongCovid ~15%, much less than many other studies (~50%) Image
BTI relative risk and absolute excess burden at 6 months for death, particularly increased for clot-related, lung sequelae Image
Less risk of #LongCovid sequelae with BTI compared with unvaccinated Covid Image
This graph breaks down the risk of BTI by out-patient or hospitalized/ICU. For the common, non-severe breakthrough infections, the risks are still increased during 6-month follow-up for multiple outcomes Image

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More from @EricTopol

May 22
It took only 10 months from sequencing #SARSCoV2 to validation of mRNA vaccines with 95% efficacy in large, placebo-controlled, randomized clinical trials Image
Read 4 tweets
May 17
The "Delta" (L452R) mutation found in both the BA.2.12.1 and BA.4/BA.5 variants is key to both immune escape and enhanced cell fusion (not present in BA.1 or BA.2). And people with prior Delta infections have better neutralization to these variants biorxiv.org/content/10.110…
The mutation map I attached (not in the preprint) was made from outbreak.info so if there are any questions, here is the link outbreak.info/compare-lineag…
Interesting new @NEJM report by same group, @ShanLuLiu1 and team @OhioState,
for Deltacron's (no L452R mutation, recombinant Omicron w/ Delta) substantial immune evasion with no enhanced sensitivity to serum from Delta wave nejm.org/doi/full/10.10…
Read 4 tweets
May 12
A big day for life science
The Tabula Sapiens, like a Periodic Table of Human Cells, ~500,000 cells analyzed, 24 tissues / organs @ScienceMagazine
"a broadly useful reference to deeply understand and explore human biology at cellular resolution" science.org/doi/10.1126/sc… ImageImage
With it, the atlas of human immune cells across tissues
science.org/doi/10.1126/sc… Image
Perspective on what was accomplished with 4 pan-tissue atlases
science.org/doi/10.1126/sc…
w/ @ScienceVisuals Image
Read 4 tweets
May 1
The uptake of smartwatches in the US is as fast as mobile phones in the 1990s
economist.com/technology-qua…
In @TheEconomist new Technology Quarterly on health and medical apps, and how wearable sensors are changing #healthcare and medical research economist.com/technology-qua… by @SlaveaChankova
A contemporary assessment of sensors and #AI algorithms for a broad range of use cases including individualized nutrition, pandemic surveillance, disease management and digital therapeutics
Read 4 tweets
Apr 29
So much for the pandemic being over
latimes.com/california/sto… @LukeMMoney @ronlin Image
From March 2021 Image
We decided..... Image
Read 4 tweets
Apr 24
You know it's an usual moment in the pandemic when New Zealand leads the world in cases per capita, And is on the descent from its Omicron wave
@OurWorldInData newsnodes.com/worldmonitor/
New Zealand with a total of 674 deaths for the entire pandemic, chance of dying approximately 1 in 7800, compared with the US, approaching 1 million confirmed deaths, 1 in 333 (24-fold)
A highly Unusual moment (anything but usual).
Sorry for my typo.
Read 4 tweets

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