Biotech2k Profile picture
May 27 14 tweets 3 min read
Building my Strategy Portfolio:

I funded it today and it will be just like I am starting out from scratch. I got $350 in it and plan to contribute about $200 to $250 each month. I went through much of my portfolio design which I will share so it might be educational.
1/ This portfolio will not be a buy and hold portfolio. It will shift and rotate based on where I think the Macro economy sits and where the best deals are in the market. That is the first thing I want to establish.
2/ I set a few rules so I buy 1 share at a time since there are zero fees. I plan to not pay up for stocks, but not sure if that will work once the bear market ends so its a guide not rule at the moment.
3/ I plan to contribute each month and keep adding to position so it becomes a real time interactive lesson for any new investors who want to learn.
4/ The first task was to pick my asset allocation between stocks, bonds, real estate and commodities. I looked at bonds and the market for them is all bad right now. Higher rates and inflation spell bad days for bonds. I picked 0% allocation for now.
5/ Real Estate is probably in the biggest bubble since 2008 with skyrocketing house prices. It will pop again eventually. I will allocate 0% until it does.
6/ Thanks to oil and inflation, commodities are already up over 50% this year and in a massive bubble. I won't touch them up here so 0% allocation to commodities.
7/ When it comes to stocks, I am going to go 100% allocation there for now until something changes. I see that the value stock are in a massive bubble with many trading at 25 to 30 P/E with declining sales due to demand destruction.
8/ The only place that is cheap is growth. I plan to go 70% growth and 30% income. I plan to pick 7 growth companies and 3 income companies for a total of 10 so its diversified from single company risk.
9/ To make things simple I will take 7 biotech stocks that I really like as my growth stocks for now. I picked them from my top 3 science themes. I will add to them 3 income stocks.
10/ I picked 10 stocks in this list, but always subject to change. I only bought 1 of them so far as the market is acting bubbly right now.
11/
Growth
#AI/#ML in biotech
1 $RLAY
2 $EXAI
3. $ABCL
#CRISPR
4. $BEAM
5. $VERV
#Snybio
6. $DNA
7. $TWST
Income
8. $MAIN
9. $SCCO
10. $VZ ???
12/ The only stock I bought any of was $VERV the other day. I am not going to chase a dead cat bounce in this bubbly market. There will be a much bigger crash later for the overall market when inflation crashes earnings with demand destruction sets in.
13/ That is where I stand. Right now, I am in the stock picking process for my companies. Its subject to change as I will go where I think the best opportunity lies.

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More from @Biotech2k1

May 29
Cell Therapies 2.0 Part 3:

This part covers Allogeneic CAR-T.
1/ Allogeneic CAR-T Therapies Image
2/ Allogeneic CAR-T takes T cells from healthy donors to create the CAR-T therapies. This is done by extracting the T cells from the donor. Then they insert the CAR receptor. They often use gene editing technologies like CRISPR to make additional edits.
Read 22 tweets
May 29
Cell Therapies 2.0 Part 2:

This deals with Autologous Cell Therapies.
1/ Autologous Therapies Image
2/ The first generation of CAR therapies started with Autologous. This was a long process that started with the drawing of blood and leukapheresis to extract the T cells. These T cells go through editing to insert the CAR receptor into each T cell.
Read 23 tweets
May 29
Cell Therapies 2.0:

This starts at the beginning with an overview of what is a CAR receptor.
1/ The Chimeric Antigen Receptor Image
2/ To understand how the CAR really works, first we will have to do a quick overview of how the immune system works.
Read 14 tweets
May 28
#Fintech upadate:

I went through $SQ, $COIN, $HOOD, $PYPL, $AFRM and $SOFI. I looked at what each company offers as services. I listened to the Q1 calls to see if the management seems to be competent.
My rankings after stage 1 was

1. $SQ
2. $PYPL
3. $COIN
4. $AFRM
5. $SOFI
6. $HOOD
Then I went through the valuation, future potential and risks. I crossed off $PYPL on lack of future growth potential. They are already at $30 billion sales only growing about 13% a year.
Read 8 tweets
May 28
1/ My notes on #Fintech. My biggest concern with Fintech is so many of these companies are now highly linked to crypto. I have my own crypto portfolio and the biggest fear here is crypto turns out to be a fad and goes away.
2/ This means companies like $COIN who is 100% about crypto are highly levered to this risk. That is not my base case, but it is a risk I must diversify away from. I went through $COIN, $SQ and $HOOD.
3/ I will make $SQ my top pick in this space. It does have some risk with its big #Bitcoin segment, but its all about the electronic payments and cash app for me. I love those business and there seems to be little competition in the small business payments space.
Read 8 tweets
May 24
I set up 2 trades today. I setup that Strategy account a few weeks ago with just $50 in it. I didn't want to contribute till the end of May. Then I used it to trade $MGTA and made a few bucks off of it. Now I am setting up a bid for $VERV. I know its only a few shares.
I figured a few shares is better than nothing and I could always buy more at the end of the month when I contribute to that Strategy account. I was very skeptical of the company because of the competition in Cholesterol space.
Now, I am betting on it down here on the management team. I have been impressed with them, and I am always willing to bet on good management. It doesn't hurt that its so cheap.
Read 6 tweets

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