Thread by @nick_krontiris

This one tried to examine the effects of the combination of chronic sleep restriction and rotating sleep schedule on blood pressure, renal sodium retention, potassium excretion, and aldosterone excretion.

- The combination of chronic sleep restriction with circadian misalignment was associated with higher systolic blood pressure despite higher sodium excretion.

- Two patterns of renal sodium excretion emerged during prolonged exposure to a rotating sleep schedule:

a) The first pattern was as participants altered between circadian alignment and misalignment, net total body sodium fluctuated due to net retention during alignment and net excretion during misalignment.

b) The second pattern evident was that over four cycles of rotating sleep schedule, a net total body sodium retention and potassium depletion occurred, without a change in aldosterone excretion.

In other words, sodium excretion is higher during misalignment compared with alignment while potassium excretion is lower, and sodium excretion decreases over a 4-day rotating sleep schedule protocol, while potassium excretion increases, without changes in aldosterone excretion.

This may suggest increased renal aldosterone sensitivity.

- The rate of renal sodium excretion displayed circadian rhythmicity independent of aldosterone excretion and the timing of behaviors (e.g., sleep/wake timing, eating, etc.).

- The rate of renal potassium excretion displayed a circadian phase effect but was also dependent upon sleep/wake timing and associated behaviors.

Sleep Restriction and Recurrent Circadian Disruption Differentially Affects Blood Pressure, Sodium Retention, and Aldosterone Secretion (open access)

frontiersin.org/articles/10.33…

#sleep #CircadianRhythm #MetabolicSyndrome #nutrition #diet #Hypertension