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Jul 28 • 5 tweets • 7 min read
We are going cell by cell to uncover the cause for #Alzheimers disease.🌟 Announcing the first major #openscience data release from SEA-AD, a @NIHAging-funded collaboration with @UWMedicine and @KPWaResearch taking steps to #endALZ. #AllenImpact 🧵1 alleninstitute.org/what-we-do/bra…
Visit: sea-ad.org to access the Seattle Alzheimer’s Disease Brain Cell Atlas and freely explore the #openscience data. #AllenImpact #endALZ #Alzheimers 🧵2
This #openscience data examines the specific types of brain cells that die off or change in #Alzheimers disease. These insights could lead to better therapies to slow or halt the disease’s progression. #endALZ #AllenImpact 🧵3
This #openscience #Alzheimers data includes:
☑️ transcriptomics comparative viewer
☑️ transcriptomic explorer
☑️ donor index & neuropathology image viewer
🔗 to SEA-AD transcriptomics data via #CZCellxGene
🔗 to SEA-AD chromatin accessibility data via @GenomeBrowser
🧵4
At @alzassociation's #AAIC22 workshops & preconference today & tomorrow, learn more about our SEA-AD research from Senior Investigator Ed Lein at: "NIA-AA Symposium: Enabling Precision Medicine for Alzheimer’s Disease Through Open Science" aaic.alz.org/program/worksh… 🧵5

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More from @AllenInstitute

Allen Institute Profile picture
Feb 9
Announcing 23 Allen Distinguished Investigator awards —representing $15.5M in total funding— aiming to advance #FrontierScience in: neural circuits of under-studied organisms, advances in mammalian synthetic biology & micropeptides involved in immunity 🧵1
alleninstitute.org/what-we-do/fro…
Allen Distinguished Investigator Robyn Crook @SFStateBIO is leading a project to study the neural control of movement in cephalopods, animals that have the most complicated nervous systems of the invertebrate world. #FrontierScience 🐙
alleninstitute.org/what-we-do/fro… 🧵 2 Image
How does a new kind of behavior arises in evolution? Allen Distinguished Investigators @neuroluci, & @SGRodriques at @TheCrick are studying larvae brains of a species of fruit fly that have evolved to jump 10 times their body length. #FrontierScience alleninstitute.org/what-we-do/fro… 🧵 3 Image
Read 13 tweets
Allen Institute Profile picture
Feb 8
Brain mapping requires thorough synaptic measurements with diverse subclasses of neurons. Check out our latest #neuroscience publication: “Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon #optogenetic stimulation”
📄 elifesciences.org/articles/71103 🧵 1
Our team [including @trav_ha, @timjarsky, @HongkuiZeng & @lukecampagnola] + @bakermind combined optogenetic stimulation with simultaneous multicellular recording to measure synaptic connections within cortical microcircuits. #optogenetics🧵 2
The reliability of multiphoton optogenetic stimulation was measured across Cre lines & connectivity measurements were verified by #patchclamp recordings 🧵 3
Read 8 tweets
Allen Institute Profile picture
Jan 24
Different cell types in the brain have their own connectivity rules and patterns. In a recently published study, our #neuroscience researchers took a deep dive into the connectomics of an important but enigmatic cell type, the chandelier cell. 🧵1

📄 elifesciences.org/articles/73783
🔬 💻 Using large-scale #electronmicroscopy with automated segmentation, we mapped the complete axo-axonic input onto pyramidal neurons (1,929 synapses in total, 1,127 from chandelier cells) in a volume of layer 2/3 of mouse visual cortex. #ImagingTheFuture #BrainMapping🧵2
By completely reconstructing the presynaptic chandelier cells, we found a novel principle of connectivity, where a group of interneurons are essentially interchangeable, but their postsynaptic targets individually regulate the amount of input they receive from the population. 🧵3
Read 7 tweets
Allen Institute Profile picture
Oct 31, 2019
In a new study out in @nature, our researchers make a big step forward in our quest to map the brain. Study findings lay the groundwork to better understand brain disorders & diseases such as #Alzheimers and #schizophrenia.

alleninstitute.org/what-we-do/bra…
This new study describes a high-resolution expansion of our #openscience Allen Mouse Brain Connectivity Atlas-- the most detailed map of connections in a mammalian brain to date. Access via: connectivity.brain-map.org
Using a computational approach, our researchers found that different sections of the cortex and thalamus can be mapped into a hierarchy, much like a company’s org chart – although not all connections followed this hierarchical structure. #brainmapping
Read 5 tweets

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