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The Allen Institute is committed to solving mysteries of bioscience — researching the unknown of human biology, in the brain, the cell and the immune system.
Jun 9, 2023 5 tweets 4 min read
An overactive inflammatory response could be at the root of many long #COVID cases, according to a new study from the Allen Institute for #Immunology and @fredhutch. 🧵 alleninstitute.org/news/many-long… Scientists have seen previous links between inflammation and long #COVID, but the new study – out today in @NatureComms – is the first to trace the persistence of these inflammatory markers over time in the same patients. (2/5) nature.com/articles/s4146…
Jul 28, 2022 5 tweets 7 min read
We are going cell by cell to uncover the cause for #Alzheimers disease.🌟 Announcing the first major #openscience data release from SEA-AD, a @NIHAging-funded collaboration with @UWMedicine and @KPWaResearch taking steps to #endALZ. #AllenImpact 🧵1 alleninstitute.org/what-we-do/bra… Visit: sea-ad.org to access the Seattle Alzheimer’s Disease Brain Cell Atlas and freely explore the #openscience data. #AllenImpact #endALZ #Alzheimers 🧵2
Feb 9, 2022 13 tweets 16 min read
Announcing 23 Allen Distinguished Investigator awards —representing $15.5M in total funding— aiming to advance #FrontierScience in: neural circuits of under-studied organisms, advances in mammalian synthetic biology & micropeptides involved in immunity 🧵1
alleninstitute.org/what-we-do/fro… Allen Distinguished Investigator Robyn Crook @SFStateBIO is leading a project to study the neural control of movement in cephalopods, animals that have the most complicated nervous systems of the invertebrate world. #FrontierScience 🐙
alleninstitute.org/what-we-do/fro… 🧵 2 Image
Feb 8, 2022 8 tweets 5 min read
Brain mapping requires thorough synaptic measurements with diverse subclasses of neurons. Check out our latest #neuroscience publication: “Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon #optogenetic stimulation”
📄 elifesciences.org/articles/71103 🧵 1 Our team [including @trav_ha, @timjarsky, @HongkuiZeng & @lukecampagnola] + @bakermind combined optogenetic stimulation with simultaneous multicellular recording to measure synaptic connections within cortical microcircuits. #optogenetics🧵 2
Jan 24, 2022 7 tweets 6 min read
Different cell types in the brain have their own connectivity rules and patterns. In a recently published study, our #neuroscience researchers took a deep dive into the connectomics of an important but enigmatic cell type, the chandelier cell. 🧵1

📄 elifesciences.org/articles/73783 🔬 💻 Using large-scale #electronmicroscopy with automated segmentation, we mapped the complete axo-axonic input onto pyramidal neurons (1,929 synapses in total, 1,127 from chandelier cells) in a volume of layer 2/3 of mouse visual cortex. #ImagingTheFuture #BrainMapping🧵2
Oct 31, 2019 5 tweets 4 min read
In a new study out in @nature, our researchers make a big step forward in our quest to map the brain. Study findings lay the groundwork to better understand brain disorders & diseases such as #Alzheimers and #schizophrenia.

alleninstitute.org/what-we-do/bra… This new study describes a high-resolution expansion of our #openscience Allen Mouse Brain Connectivity Atlas-- the most detailed map of connections in a mammalian brain to date. Access via: connectivity.brain-map.org