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Press release for new Canadian research paper:
“Histamine-producing gut bacteria can trigger chronic abdominal pain. The discovery has been named Klebsiella aerogenes, the McMaster-Queen (MQ) strain”
sciencedaily.com/releases/2022/…
#IrritableBowelSyndrome #IBS #IrritableBowel
1/
Press release for new Canadian research paper:
“Histamine-producing gut bacteria can trigger chronic abdominal pain. The discovery has been named Klebsiella aerogenes, the McMaster-Queen (MQ) strain”
sciencedaily.com/releases/2022/…
#IrritableBowelSyndrome #IBS #IrritableBowel
1/
2/
“The culprit is what has now been named Klebsiella aerogenes, the McMaster-Queen (MQ) strain, identified in up to 25 per cent of gut microbiota samples from patients with #IBS. Researchers examined stool microbiota samples from both Canadian and American patient cohorts”
“The culprit is what has now been named Klebsiella aerogenes, the McMaster-Queen (MQ) strain, identified in up to 25 per cent of gut microbiota samples from patients with #IBS. Researchers examined stool microbiota samples from both Canadian and American patient cohorts”
3/
“Researchers from McMaster University and Queen's University have discovered a gut bacterial 'super-producer' of histamine that can cause pain flare-ups in some patients with #irritablebowelsyndrome (#IBS).”
“Researchers from McMaster University and Queen's University have discovered a gut bacterial 'super-producer' of histamine that can cause pain flare-ups in some patients with #irritablebowelsyndrome (#IBS).”
4/
“We followed up these patients for several months & found high levels of stool histamine at the time when the patients reported severe pain, & low stool histamine when they were pain-free," said senior author Premysl Bercik, professor of medicine…& a gastroenterologist”
#IBS
“We followed up these patients for several months & found high levels of stool histamine at the time when the patients reported severe pain, & low stool histamine when they were pain-free," said senior author Premysl Bercik, professor of medicine…& a gastroenterologist”
#IBS
5/
“The study found that when the mice colonized with histamine producing bacteria were fed a diet low in fermentable carbohydrates, bacterial histamine production dramatically decreased. This was due to change in bacterial fermentation and acidity within the gut (contd)”
#IBS
“The study found that when the mice colonized with histamine producing bacteria were fed a diet low in fermentable carbohydrates, bacterial histamine production dramatically decreased. This was due to change in bacterial fermentation and acidity within the gut (contd)”
#IBS
6/
“(Contd) which inhibited the bacterial enzyme responsible for histamine production.
Bercik said that these results explain the beneficial effects of a low fermentable diet observed in patients with #IBS”
#FODMAP #FORMAPS #FODMAPdiet #irritablebowelsyndrome
“(Contd) which inhibited the bacterial enzyme responsible for histamine production.
Bercik said that these results explain the beneficial effects of a low fermentable diet observed in patients with #IBS”
#FODMAP #FORMAPS #FODMAPdiet #irritablebowelsyndrome
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“It is known that patients with #IBS have more mast cells in their intestines, and that some of them improve with treatments targeting mast cells or histamine, such as mast cell stabilizers or antihistamines”
#irritablebowelsyndrome
“It is known that patients with #IBS have more mast cells in their intestines, and that some of them improve with treatments targeting mast cells or histamine, such as mast cell stabilizers or antihistamines”
#irritablebowelsyndrome
8/
“‘Although mast cell treatment in #IBS has been explored, a novel approach based on our research would be targeting the bacterial histamine production or H4R pathways,’ Bercik said”
#irritablebowelsyndrome
“‘Although mast cell treatment in #IBS has been explored, a novel approach based on our research would be targeting the bacterial histamine production or H4R pathways,’ Bercik said”
#irritablebowelsyndrome
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The “study explains why increased mast cells are found in #IBS & suggests that H4 receptor pathway plays a major role in this process.
‘If we block the H4 receptors, then we can prevent recruitment of mast cells to the colon & subsequently the development of abdominal pain’”
The “study explains why increased mast cells are found in #IBS & suggests that H4 receptor pathway plays a major role in this process.
‘If we block the H4 receptors, then we can prevent recruitment of mast cells to the colon & subsequently the development of abdominal pain’”
10/
“‘Many but not all #IBS patients will benefit from therapies targeting this histamine driven pathway,’ said co-first author David Reed…Reed said that one or more biomarkers of this pathway could be used to find the patients most likely to benefit”
#irritablebowelsyndrome
“‘Many but not all #IBS patients will benefit from therapies targeting this histamine driven pathway,’ said co-first author David Reed…Reed said that one or more biomarkers of this pathway could be used to find the patients most likely to benefit”
#irritablebowelsyndrome
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Research paper:
Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice. Science Translational Medicine, 2022; 14 (655)
science.org/doi/10.1126/sc…
#IBS #irritablebowelsyndrome
Research paper:
Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice. Science Translational Medicine, 2022; 14 (655)
science.org/doi/10.1126/sc…
#IBS #irritablebowelsyndrome
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