Thread by @LizHighleyman

And now at #AIDS2022: ad hoc #monkeypox media briefing with @mdoherty_hiv, Marina Klein, @ProfSharonLewin, @dr_demetre, @klts0 & @profchloeorkin.

.@dr_demetre: There's not one magic bullet. Learned lessons from #HIV that absolutes tend not to work, so focus on harm reduction. #Monkeypox vaccine supply & demand mismatch will probably go through the summer & fall. #AIDS2022

Marina Klein: Montreal was able to graft #monkeypox vaccine effort onto existing COVID vaccine infrastructure, with low threshold, evening hours, broad eligibility for gay/bi/MSM. #AIDS2022

.@mdoherty_hiv: #Monkeypox epidemiology is becoming more clear as time goes on. 98% gay/bi/MSM. Very limited but some cases in women, children, health care workers. Does not appear to be major secondary transmission to HCW workers or we would have expected more cases. #AIDS2022

.@profchloeorkin: #Monkeypox clinical outcomes reassuringly not different for HIV+ & HIV-. Though few complications, some of worst were seen in people w/HIV. Jynneos vaccine response after 1st dose was lower for HIV+ -- suggests they should be prioritized for 2nd doses. #AIDS2022

.@profchloeorkin: One of the gaps is voice of grassroots clinicians -- we have noticed findings in the real world that public health officials weren’t aware of. #AIDS2022

.@klts0: MPX has been rising in Nigeria since 2017, not present from time immemorial. They are experiencing the same fear, pain, grief as those in new outbreak. Don't let "endemic" be end of the discussion about MPX in West & Central Africa.

Simon Collins: people are getting shots in their arms but not enough info on vaccine efficacy. Being told everything from 1 dose is fine to protection 2 weeks after 2nd dose. People could go out thinking they're adequately protected when they're not. #AIDS2022

My take: inconsistent message about Jynneo #monkeypox vaccine effectiveness after 1st dose is a problem. HIV+ men in particular may not be adequately protected after 1 dose, but really don’t have enough data for anyone. #AIDS2022