#Monkeypox vaccine messaging is difficult & conflicting because there's not enough research. Data so far is based on immunogenicity (essentially, antibody production) not real-world effectiveness. Starting with 1 dose is a good strategy to get more people some protection ASAP. 1/
But saying a single dose provides adequate protection is premature. In particular, people with #HIV have a lower response rate & it seems like they should be prioritized for 2nd doses. @dr_demetre says @US_FDA stands by its recommended 2-dose regimen. #AIDS2022 2/
I went into #AIDS2022 #monkeypox media briefing with many questions, but most don't yet have answers, including importance of various transmission routes in the real world, asymptomatic transmission, does HIV influence susceptibility, TPOXX efficacy, can isolation be shorter. 3/
.@profchloeorkin says grassroots clinicians have been key -- they notice findings in the real world that public health officials weren’t aware of. @mdoherty_hiv expressed gratitude to men who have shared their stories & pictures to help us understand.

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More from @LizHighleyman

Jul 31
And now at #AIDS2022: ad hoc #monkeypox media briefing with @mdoherty_hiv, Marina Klein, @ProfSharonLewin, @dr_demetre, @klts0 & @profchloeorkin.
.@dr_demetre: There's not one magic bullet. Learned lessons from #HIV that absolutes tend not to work, so focus on harm reduction. #Monkeypox vaccine supply & demand mismatch will probably go through the summer & fall. #AIDS2022
Marina Klein: Montreal was able to graft #monkeypox vaccine effort onto existing COVID vaccine infrastructure, with low threshold, evening hours, broad eligibility for gay/bi/MSM. #AIDS2022
Read 9 tweets
Jul 31
Another article done, so off to final edition of #NoPantsNoProblem. End of an era -- this queer party has accompanied International AIDS Conferences for more than a decade. Proceeds fund global grants for HIV+ women. @gnpplus @Visual_AIDS 1/

visualaids.org/blog/no-pants-…
Yeah, it's fraught to have a party of people, many of them HIV+, who've traveled from all over the world in the era of COVID & now #monkeypox. A lot of people won't feel safe going -- & that's completely understandable & rational. 2/
Lots of gay/bi/trans men there, but I don't feel at any risk for monkeypox via the air or casual contact. It'd suck to get COVID while covering a conference, but if I'm going to sit in my hotel room & not take advantage of social opportunities, I might as well have stayed home...
Read 4 tweets
Jul 30
And now, the Future of #HIV Media Coverage -- plus COVID & I won't be surprised if they mention #monkeypox. With @picardonhealth, @sciencecohen, @sarahboseley, @boosulyn, @SipokaziF, @apoorva_nyc, @rkhamsi & @ProfSharonLewin #AIDS2022
.@sciencecohen: There used to be AIDS journalists, that's rare now. With COVID, every reporter became a health reporter. Public more informed about science than ever before. But, adds @picardonhealth, they're more misinformed as well. #AIDS2022
How to balance COVID -- & now monkeypox -- with ongoing issues like #HIV/#AIDS?
@apoorva_nyc: When people stop seeing a disease as a threat to themselves, they don’t pay attention anymore. How do we get people to care about something that affects a specific population? #AIDS2022
Read 12 tweets
Jul 29
Important🧵from @thrasherxy. We've all seen the excerpts posted here from historical descriptions of #monkeypox transmission & symptoms, but the current outbreak among gay/bi/trans/MSM looks very different. 1/
It's quite possible low-level MPX spread is happening via traditional transmission routes while *at the same* time an explosive outbreak is occurring, via different routes, in a specific population. 2/
We've seen something similar with sexually-associated outbreaks of hepatitis C among gay/bi/MSM. This suggests it's possible for a pathogen to be both an STI & not an STI simultaneously (Schrödinger's STI?) 3/
Read 4 tweets
Jul 29
.@CAPublicHealth has released new #monkeypox data with some eagerly awaited demographics. Still overwhelmingly gay/bi/MSM. Among 786 cases are 5 trans men, 3 cisgender women, 3 trans women & 2 non-binary. 45% white, 36% Latino, 9% Black & 6% Asian.
cdph.ca.gov/Programs/CID/D…
According to census.gov, #monkeypox distribution for Latino & Black people isn't that far off from statewide population percentages (40% & 7%, respectively. But other sources put the Latino population share much lower, at around 19%.
But statewide numbers can mask local variation. One of the first thing I noticed in SF's demographics is that ~30% of monkeypox cases are among Latinos -- about twice their share of the city's population.
sf.gov/sites/default/…
Read 5 tweets
Jul 29
A Southern California man appears to be cured of #HIV after undergoing a stem cell transplant to treat leukemia, Dr. Jana Dikter of @cityofhope reported this week at #AIDS2022. @eBARnews
ebar.com/story.php?ch=N…
This risky procedure isn't suitable for most people with HIV, it offers clues for more feasible approaches. "These cures are no longer anecdotal - we now have a real case series," said Dr. Steven Deeks of @UCSF . #AIDS2022
.@iasociety put journalists in a bind by holding press conferences so early. Dikter gave a summary at Wed press briefing & @cityofhope issued a press release, but her actual presentation isn't until Monday. Of course, mainstream media reported it right away after the presser.
Read 5 tweets

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