Interestingly enough, in this one, plasma levels of cis-vaccenic acid, a fatty acid that can be endogenously synthesized through the de novo lipogenesis pathway, was associated with a beneficial cardiovascular risk profile, but with a higher risk for all-cause mortality.
- In this prospective cohort of Dutch adults with normal HDL-c and TG, higher levels of cis-C18:1n7 in plasma phospholipids were positively associated with all-cause mortality.
- In other words, higher DNL activity, reflected by a higher level of cis-C18:1n7, may be related to a higher risk of mortality.
Circulating de novo lipogenesis fatty acids and all-cause mortality in a prospective Dutch population cohort (open access)

doi.org/10.1016/j.jacl…

#nutrition #diet #Obesity #MetabolicSyndrome #NAFLD #MAFLD

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Aug 5
This one tried to provide updated estimates on the prevalence and determinants of overweight and obesity in Europe.

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Aug 5
This Mendelian randomization study provides evidence that genetically predicted walking may reduced the risk of Alzheimer’s disease. Image
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Aug 5
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Aug 5
In line with several previous studies, this one found hypoglycemia (glucose <3.0 mmol/L) to result in declines in important aspects of cognitive function, with the decline being consistent in adults with or without diabetes and largely independent of clinical factors. ImageImage
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This one found an inverse, independent, and graded association of cardiorespiratory fitness with mortality risk across the age spectrum (including septuagenarians and octogenarians), men, women, and all races. Image
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The findings of this Mendelian randomization and protein-truncating variant analysis do not support a causal association between GDF-15 plasma levels and human cardiometabolic disease factors in humans.
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