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Aug 4 • 4 tweets • 2 min read
Interestingly enough, in this one, plasma levels of cis-vaccenic acid, a fatty acid that can be endogenously synthesized through the de novo lipogenesis pathway, was associated with a beneficial cardiovascular risk profile, but with a higher risk for all-cause mortality.
- In this prospective cohort of Dutch adults with normal HDL-c and TG, higher levels of cis-C18:1n7 in plasma phospholipids were positively associated with all-cause mortality.
- In other words, higher DNL activity, reflected by a higher level of cis-C18:1n7, may be related to a higher risk of mortality.
Circulating de novo lipogenesis fatty acids and all-cause mortality in a prospective Dutch population cohort (open access)

doi.org/10.1016/j.jacl…

#nutrition #diet #Obesity #MetabolicSyndrome #NAFLD #MAFLD

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More from @nick_krontiris

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Aug 5
This one tried to provide updated estimates on the prevalence and determinants of overweight and obesity in Europe.

It suggests that half of the European adult population is overweight and almost one in every eight are obese. Image
- Obesity prevalence was 13% in 2017-2018, with higher rates in women, older adults, and those with a lower socioeconomic status.
- Large variability was observed across countries, with obesity prevalence ranging between 8% in Italy and 21% in Romania.
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Aug 5
This Mendelian randomization study provides evidence that genetically predicted walking may reduced the risk of Alzheimer’s disease. Image
- Genetically predicted higher levels of walking were found to decrease the risk of AD.
- Interestingly, the study failed to find any associations between genetically predicted overall activity, sedentary behavior, and moderate-intensity activity with AD.
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Nick Krontiris Profile picture
Aug 5
This systematic review and meta-analysis of randomized controlled trials finds that resistance training exercise may promote increases in bioelectrical phase angle, an indicator of body cell mass and cellular health, in older adults. Image
- Phase angle is an indicator of body cell mass and cellular health, that is also moderately associated with muscle quality.
- Resistance training programs lasting ≥ 8 weeks were found to result in phase angle increases in participants aged ≥ 60 years.
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Aug 5
In line with several previous studies, this one found hypoglycemia (glucose <3.0 mmol/L) to result in declines in important aspects of cognitive function, with the decline being consistent in adults with or without diabetes and largely independent of clinical factors. ImageImage
- In this study, the authors enrolled clinically distinct subgroups of people with diabetes, and control subjects, using the same methodology allowing for direct comparison between different diabetic phenotypes and subjects without diabetes.
- Hypoglycemia deteriorated cognitive performance in all groups of participants to a similar extent, with effect sizes ranging from small to medium.
Read 5 tweets
Nick Krontiris Profile picture
Aug 5
This one found an inverse, independent, and graded association of cardiorespiratory fitness with mortality risk across the age spectrum (including septuagenarians and octogenarians), men, women, and all races. Image
- This is an analysis of more than 750,000 U.S. veterans, which included a large numbers of septuagenarians, octogenarians, African Americans, Hispanics, Native Americans, and women.
- During a median follow-up period of 10.2 years and more than 7.8 million person-years of observation, adjusted associations of CRF and mortality risk were inverse and strongly graded across the age spectrum, sex, and race.
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Aug 4
The findings of this Mendelian randomization and protein-truncating variant analysis do not support a causal association between GDF-15 plasma levels and human cardiometabolic disease factors in humans.
- Related:

link.springer.com/article/10.100…
- The analysis confirmed strong correlations of GDF15 plasma levels with a range of clinical parameters (e.g. age, smoking and BMI) and human diseases (e.g. diabetes, cardiovascular and respiratory disease), as well as several inflammatory biomarkers.
Read 8 tweets

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