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Aug 12 • 6 tweets • 2 min read
This systematic review and meta-analysis suggests that calorie restriction is effective on improving NAFLD markers, and that changing diet composition may have the potential to complement diet-induced weight loss.
- A dose–response association between weight loss and NAFLD surrogate markers was found.
- Meta-regression results suggested that diet-induced improvement in liver stiffness was greatest in the youngest patients and decreased with age.
- "There was limited evidence that over 2-weeks, a carbohydrate-restricted diet reduced liver fat more than a calorie-restricted diet"
- "There was consistent evidence that MD interventions improved one or more measures of NAFLD activity and meta-analysis showed a significant effect on post-intervention ALT (alanine aminotransferase), FLI (Fatty Liver Index) and LSM (liver stiffness measures)."
The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis (open access)

doi.org/10.1016/j.clnu…

#nutrition #diet #Obesity #weightloss #NAFLD #MAFLD

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More from @nick_krontiris

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Aug 14
This systematic review and meta-analysis finds that both unilateral and bilateral resistance training may improve athletic performance, but the former may be superior on improving unilateral jumping performance and the latter bilateral strength performance.
- Both unilateral and bilateral resistance training were found to improve athletic performance, with no differences in performance measures.
- Subgroup analysis showed that unilateral resistance training can improve unilateral jumping performance with a large effect, but probably provides no benefit on improving unilateral strength performance in comparison to bilateral exercises.
Read 6 tweets
Nick Krontiris Profile picture
Aug 14
This systematic review and meta-analysis suggests that high HbA1c variability in individuals with type 2 diabetes may lead to micro- and macro-vascular complications and related death.
- Individuals with type 2 diabetes among the highest quantile HbA1c of all 3 variability metrics had increased risks of all-cause mortality, cardiovascular events, progression to CKD, amputation, and peripheral neuropathy.
- Those among the highest quantile of at least one HbA1c variability metric hadh increased risks of kidney failure, progression to albuminuria, diabetic foot ulcer, and retinopathy.
Read 4 tweets
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Aug 14
In this one, even though 6 months CrossFit training (2×60 min/week) did not improve measures of well-being in inactive adults with predominantly sitting or standing occupations, it resulted in improved mobility and strength.
- The study recruited individuals with a predominantly standing or sitting occupation that did less than two muscle and/or mobility enhancing training sessions per week prior study participation.
- After 6 months significant effects were found for mobility and strength, but not for measures of well-being.
Read 6 tweets
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Aug 13
This study tried to investigate how self-identified dietary lapses, which are defined broadly as eating that is inconsistent with one or more dietary goals, affect reported dietary intake among individuals undergoing a lifestyle modification intervention. ImageImage
- When controlling for their usual intake, participants consumed more calories and added sugar on days on which they reported dietary lapses.
In comparison to prescribed calorie goals (1200–1800 kcals/day based on starting weight), participants consumed an unadjusted average of 253.85 calories above their prescribed goal on lapse days...
Read 6 tweets
Nick Krontiris Profile picture
Aug 13
This one found a high adipose tissue insulin resistance in normotensive individuals at baseline, as assessed by adipo-IR, to be associated (although weakly) with new-onset hypertension. Image
- In this study, the authors investigated the association between three insulin resistance indices (adipo-IR, HOMA-IR, and the Matsuda index) and hypertension in older Japanese individuals.
- In the cross-sectional analysis, all of these insulin resistance indices were statistically significantly associated with blood pressure levels.
Read 10 tweets
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Aug 13
This one suggests that aerobic physical activity durations of 3 hours/week and resistance training exercise ~1–2 times/week may substantively reduce the risk of all-cause mortality, with their combination confering additional mortality risk reduction beyond cardio alone. ImageImage
- Higher aerobic PA duration was found to be robustly associated with lower mortality risk and was optimised at ~3 hours/week, largely independent of age and sex. ImageImage
Across all models, an inverse association of aerobic PA with mortality risk with doses as short as ~1 hour/week were found, with results suggesting little additional mortality risk reduction beyond 3 hours/week.
Read 14 tweets

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