Thread by @vipintukur

In late 2020, the #JCVI of #England made two important recommendations for the initial roll-out of the #COVID19 vaccine.

1-Vaccines should be targeted to the elderly and vulnerable to maximally preventing disease rather than infection 1/

2-To increase the interval between first and second doses of ChAdOx vaccine for 3 to 12-weeks in order to have a higher efficacy with this longer dose interval. 2/

A new modelling study from England shows that targeting the most vulnerable had the biggest immediate impact (compared to targeting younger individuals who may be more responsible for transmission). 3/

The 12-week delay was also highly beneficial, estimated to have averted between 32-72,000 hospital admissions and 4-9,000 deaths over the first 10 months of the campaign (Dec’ 2020 - Sep 2021)

medrxiv.org/content/10.110…