What are the arguments for and against the combination of conventionally fractionated radiotherapy (2 Gy / fx; ~10-45 fractions) with concurrent immunotherapy (ipi, nivo, etc)?
Proponents of combination therapy will reference:
1, numerous studies of RT + ICI, all seemingly safe
2, ICI is the best option if cisplatin ineligible
3, RT is immunostimulatory, should boost effect of ICI, RT + ICI is synergistic
Counterargument to #1:
Yes, there are data on toxicity, but almost all studies use SBRT/SRS, ie, > ~5 Gy per fraction x 1-5 fractions (not 2 Gy). There are limited mature studies on efficacy.
Meta-analysis from @PennStHershey MD PhD student Mike Sha:
1, #RadOnc oral boards are the most clinically relevant exams (vs rad bio, physics, written exam, inservice, etc).
Many of the questions about management come straight from @NCCN guidelines, so use these as a primary reference.
2, have a prepared script of what to say for standard questions. eg, workup, setup, margins, doses
Here is an example for prostate ca history / workup #pcsm
How to run a meeting at an academic medical center
🧵
Originally, this presentation was for our oncology trainees, and we figured we would share it on #AcademicTwitter#MedTwitter to maximize the impact of your meetings.