Defining #celiac disease and non-celiac gluten (more accurately, wheat) sensitivity 
#Celiac disease is common
#Celiac associations
Most #celiac disease patients have "atypical" symptoms
Rarely can present with acute severe abdominal pain from intussusception or bowel edema
Rarely can present with acute severe abdominal pain from intussusception or bowel edema
Diagnostics
🧬start with anti-TTG IgA
💡For serology and biopsy, need to be eating gluten to avoid false negative
🧬start with anti-TTG IgA
💡For serology and biopsy, need to be eating gluten to avoid false negative
Caveats with #celiac serology
Endoscopy in #celiac disease
Histology of #celiac disease
Villous blunting is NOT specific to #celiac disease! (This is why we need serology)
Do we need a biopsy to diagnose #celiac disease? Not necessarily...
HLA DQ2/DQ8
💡NOT diagnostic, since up to 40% of healthy population has; good for EXCLUDING #celiac disease
💡NOT diagnostic, since up to 40% of healthy population has; good for EXCLUDING #celiac disease
Diagnosing #celiac disease when already on a gluten-free diet
Management of #celiac disease: gluten-free diet
🦴osteopenia/osteoporosis
🧫cancer
☠️mortality
🧫cancer
☠️mortality
Disease monitoring
What about ongoing symptoms on a strict gluten-free diet?
#Celiac disease summary
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