2) The orthodox origin story has negligible evidence to support it. No #Ebola was found at Meliandou, Guinea, or elsewhere in wild animals nor was it diagnosed or positively tested in 'patient zero' or his contacts. The nearest known wild source was a whopping 3,000 km away
3) The subsequent epidemiological investigation back from the first confirmed cases was also highly speculative. E.g. the father and others disagree that his family had #Ebola, even tho' the epidemiology was supposedly largely based on interviews. #Ebola2014
4) However, there is a lab not far from Meliandou, over the border in Sierra Leone. It isnt clear if the US-funded Viral Hemorrhagic Fever lab in Kenema studied #Ebola there but certainly @metabiota, who worked there, was also collecting viruses from Central Africa #Ebola2014.
5) Moreover, numerous contemporaneous on the ground accounts alleged very lax biosafety procedures at the VHFC Kenema lab both before and after the outbreak of #Ebola2014 and the VHFC credibly alleged that, amazingly, @metabiota was culturing #Ebola virus.
6)Phylogenetics does not support an outbreak in Guinea, if anything it favours Sierra Leone a) because a Guinea origin generates anomalies and b) because it clearly shows there was an undiagnosed early outbreak in Sierra Leone that predated official first appearance of #Ebola2014
7) An undiagnosed outbreak beginning much earlier than officially acknowledged in Sierra Leone concords with the assessments made at the time by no less than @WHO AND @MSF AND @CDCgov who were there at the time.
8) Such inconsistencies and anomalies were known to but ignored by the researchers who confidently stated a Guinean origin. Why did they ignore the pointers to Sierra Leone? Maybe they just simply feared African voices, like @africanistpress who pointed at the VHFC lab?
9) A big one: Many of the key players, like Eddie Holmes, Kristian Andersen, Andrew Rambaut, Bob Garry, overlap with those opposing a #lableak by #COVID19 as do their scientific and phylogenetic suppression methods and techniques. So maybe they really knew more?
Hence the implications of a #Ebola2014 lab leak are impt in their own right but also to understanding #COVID19 and #OriginOfCovid and even further to preventing future outbreaks. When epidemiologists blame an outbreak on the wildlife trade, be sceptical. To be continued...
Wanted to try a twitter tutorial (our first, so bear with it) on the v. interesting #CRISPR issues raised by the recent birth of #geneedited#Calf "Cosmo", thx to @UCDavis researcher @BioBeef. Author @MeganMolteni gamely brought in some perspective but no technical critic, so....
The following are issues neglected or barely raised in the text but should be born in mind while reading the article, which described attempts to add the SRY sex "determining" gene and make all male animals: wired.com/story/a-crispr…
2 The researchers began w/a "crude portrait" #genome sequence (so the first embryos died because the researchers chose the wrong place to edit). The premise of #geneediting is precision but this requires EXACT knowledge of the target genome, which almost invariably is lacking.