TRANSFORM-HF

What do we really know about efficacy of furosemide vs torsemide?

I am sure @robmentz and team have something to say about this 👊🏾

pubmed.ncbi.nlm.nih.gov/33714745/

#AHA #LBCT @AHAScience @noshreza
Chlorthalidone versus HCTZ - pragmatic emr study by @Areefishani et al. After #SPRINTTrial I use chlorthalidone. What’s the evidence?

pubmed.ncbi.nlm.nih.gov/35390512/

#AHA #LBCT @AHAScience @noshreza
PPAR-alpha (e.g., fenofibrate, permafibrate) - Are triglycerides as a target out for CV event reduction, or just this mechanism?

pubmed.ncbi.nlm.nih.gov/30342298/ @APradhanBrigham to present 👊🏾

#AHA #LBCT @AHAScience @noshreza
#CRISPR tech is a potential game changer, for TTR and other diseases. Looking fwd to Dr Gillmore’s presentation. #amyloidosis

pubmed.ncbi.nlm.nih.gov/34215024/

#AHA #LBCT @AHAScience @noshreza
#Coachtrial for acute #HF presenting at the ED. Does risk stratification and rapid amb care improve outcomes?

pubmed.ncbi.nlm.nih.gov/33984316/

#AHA22 #LBCT @AHAScience @noshreza
Will patient reported health quality impact patient outcomes and clinical decision making in #HF?

clinicaltrials.gov/ct2/show/NCT04…

#AHA22 #LBCT @AHAScience @noshreza

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More from @VietHeartPA

Nov 7
@mmillermd1 @PennCardiology @DLBHATTMD @UM_Cardiology @ASPCardio @nationallipid @BudoffMd @Medscape EPA effect on ASCVD in Japanese pts w/chronic CAD and EPA/AA ratios <0.4, on statins.

🐟EPA 1.8 gm (like JELIS)
🐟EPA baseline 46 ug/mL (JELIS, 96)
🐟All on statins, randomized to control or EPA, no blinding (like JELIS)

#aha22 1/ @AHAScience ImageImageImageImage
@mmillermd1 @PennCardiology @DLBHATTMD @UM_Cardiology @ASPCardio @nationallipid @BudoffMd @Medscape @AHAScience N=2506

🐟interesting drop out rate/protocol deviation, covid era?
🐟LDL-C baseline, similar to reduce it
🐟EPA median 46 ug/mL, higher than reduce it (26), lower than Jelis (96).
🐟hsCRP ~0.40
2/ #aha22 ImageImage
@mmillermd1 @PennCardiology @DLBHATTMD @UM_Cardiology @ASPCardio @nationallipid @BudoffMd @Medscape @AHAScience 1,800 mg EPA
🐟46 ➡️ 145 ug/mL (26➡️150 ug/mL, reduce it)
🐟LDL-C, Trigs, HDL-C no change
🐟hsCRP went down in both
3/ #aha22 Image
Read 5 tweets
Nov 5
Dr @DrCaliff_FDA providing the opportunities we have to improve health in the US #AHA22
#AHA22 What the @US_FDA hopes and seeks to do
Throwing dollars at “health”doesn’t = improved health. This is staggering. We need to change what and how we deliver #Healthcare and where the $$ are spent #aha22
Read 4 tweets
Nov 5
I have never claimed to be fashionable and rarely do I ever match ☺️

I am wearing my heart shoes and my red dress tie from @HeartNews @AHAScience @GoRedForWomen

#AHA22 Day 1 Image
My shoe buddy and frankly the genesis for why I purchased these shoes @KnightSNPs

Stop by S3156. Dr Knights poster on #disparities in #research. #aha22

We need to fix it. ImageImage
Also, don’t miss Dr Horne’s poster on #statin and #etoh. S3063

If transaminases are elevated and statins are indicated: keep the statin, abstain from etoh
@Intermountain @KirkKnowlton
#aha22 ImageImageImageImage
Read 4 tweets
May 17, 2021
#ACC21

Join us now - Prevention and Health Promotion and the year in review. Dr. Donna Polk presenting.

acc21.virtual-acc.org/topic-essentia…
#ACC21

The "Covid 19" weight gain?
#ACC21

Yes, the "covid 19" weight gain did occur. How do we combat it though? why did it occur?
Read 35 tweets
May 16, 2021
#ACC21

Ensuring diversity - acc21.virtual-acc.org/engage-channel/

Come listen to these wonderful talks in how we strengthen diversity -
#ACC21

I love the advice to have cross professional recruiting, e.g. include other #ACCCVT in recruiting physicians and vice-versa.
#ACC21

Make interprofessional practice a baseline. Implement this early and foundational to curricula.

Make it "a thing" to utilize the strengths of team members in care.

Respect the title! All have earned theirs. Introduce by title in front of the patient

#CardioTwitter
Read 24 tweets
May 16, 2021
#ACC21

Nice work #STRENGTHTrial team! #OM3

First - primary endpoints not achieved. This is a sub-study.

Questions attempted to address:
- Could higher EPA explain favorable outcomes?

- Could DHA component have exactly counterbalanced benefits of EPA?

1/
#ACC21
Recall #STRENGTHtrial randomized 13,000+. Similar MACE outcomes to #REDUCEIT.

STRENGTH sub-study looks at top tertile achieved EPA and DHA compared to corn oil.'
2/
#ACC21

-Interesting that high intensity statin use in top tertile was 10% less than other tertiles and corn oil group.

-LDL-C was 7 mg/dL higher in top tertile group than next highest (T1)

-Achieved EPA (443%) and DHA (68%) is c/w with dose 2200 mg, 800 mg respectively

3/
Read 10 tweets

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