Thread by @nick_krontiris

This umbrella review of meta-analyses found strong evidence to suggest that physically active individuals have a lower risk of developing Alzheimer's Disease and that exercise interventions exert numerous benefits on patients who already have Alzheimer's Disease.

- The present umbrella review found that there is strong evidence of a protective effect of regular physical activity against Alzheimer's Disease risk, with active individuals having a~ 30–40% lower risk compared with inactive individuals.

- "Although a dose–response association between physical activity volume and risk of dementia has been previously reported...

Ref:
doi.org/10.1136/bmjope…

"...we found no meta-analytical evidence supporting this association specifcally in AD. Moreover, the ESs found across studies were very similar, and therefore, no clear inferences can be made regarding a potential dose–response association."

BUT!

- "Regarding PA intensity, a trend toward an inverse dose–response association with the incidence of AD has been observed...

"...Specifically, individuals who practiced either high intensity and moderate-intensity PA seemed to present with lower odds of AD compared with inactive peers or those who only performed low-intensity activities...

"...but the risk reduction was higher among those who performed high-intensity PA (−38% and −29% for high-intensity and moderate-intensity PA, respectively)."

- The present umbrella review also found strong evidence of beneficial effects of exercise interventions in patients already affected by Alzheimer's Disease, including improvements in global cognitive function, some measures of physical performance, and functional independence.

"Strength training and aerobic exercise can be beneficial, but further evidence is needed to elucidate the most efective exercise characteristics for patients with AD, as only two studies performed a sensitivity analysis by type of exercise."

Refs:
doi.org/10.1016/j.arr.…
doi.org/10.3390/ijerph…

Effects of physical activity and exercise interventions on Alzheimer’s disease: an umbrella review of existing meta-analyses

doi.org/10.1007/s00415…

#exercise #Workout #TrainHard #GymLife #GymTime #muscle #strength #lift #GetStrong #cardio #hiit