This one found serum klotho levels, a protein primarily produced by the kidney which is considered to be anti aging and its levels appear to increase with exercise, to be negatively associated with heart failure in middle-aged and older adults.
- Each 2.72 pg/ml increase in Klotho concentration decreased the risk of heart failure by 45% after controlling for potential covariates, and such a negative and significant association was also found in half of the subgroups.
"Our findings indicated that a higher serum Klotho concentration was significantly associated with a lower risk of HF in half of the subgroups...
"...Although the ORs were not significant among participants with age ≤50 years, age ≥70 years, female sex, diabetes, no hypertension, CHD, or eGFR< 60 ml/min/1.73 m2...
"...the ORs in these subgroups were all < 1, indicating that the effects of serum Klotho concentration on HF were stable among different subgroups...
"...Therefore, our study provided scientific evidence that serum Klotho concentration was powerful for assessing the chance of having HF in these middle-aged and older adults."
"One may speculate that renal function influenced the association between serum Klotho concentration and HF...
"...Klotho concentration positively correlated with renal function, and eGFR was negatively associated with HF...
"...In our subgroup analysis with stratification by eGFR, the negative association between Klotho concentration and HF was nonsignificant in patients with eGFR < 60 ml/min/1.73 m2"
OK, so very possible that at least a large part of these findings are mediated by renal function.
Association between serum klotho concentration and heart failure in adults, a cross-sectional study from NHANES 2007–2016…

#exercise #Workout #TrainHard #GymLife #GymTime #muscle #strength #lift #GetStrong #cardio #hiit

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Nov 14
Here, leisure-time sedentary behavior was associated with the risk of dementia incidence and mortality, but replacing it with a short duration of physical activity was associated with a decreased risk of dementia, with the effect being stronger in APOE ε4 carriers. Image
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Nov 14
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Nov 14
This one in Iranian adults found higher dietary oxalate intakes to be associated with an increased risk of developing hypertension and chronic kidney disease, especially when consuming lower calcium intakes.
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Nov 13
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Nov 13
This one found an inverse association between folate intake and colorectal cancer risk, while identifying 3 genes with suggestive interactive effects between total folate consumption and colerectal cancer risk: GSTA1, TONSL, and AGA.
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- Both the class with the overall unhealthiest lifestyle and that with a high BMI were biologically 1.7–3.3 years older than the classes with healthier lifestyle patterns when DNAm GrimAge was used...
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