Thread by @nick_krontiris

This one found serum klotho levels, a protein primarily produced by the kidney which is considered to be anti aging and its levels appear to increase with exercise, to be negatively associated with heart failure in middle-aged and older adults.

- Each 2.72 pg/ml increase in Klotho concentration decreased the risk of heart failure by 45% after controlling for potential covariates, and such a negative and significant association was also found in half of the subgroups.

"Our findings indicated that a higher serum Klotho concentration was significantly associated with a lower risk of HF in half of the subgroups...

"...Although the ORs were not significant among participants with age ≤50 years, age ≥70 years, female sex, diabetes, no hypertension, CHD, or eGFR< 60 ml/min/1.73 m2...

"...the ORs in these subgroups were all < 1, indicating that the effects of serum Klotho concentration on HF were stable among different subgroups...

"...Therefore, our study provided scientific evidence that serum Klotho concentration was powerful for assessing the chance of having HF in these middle-aged and older adults."

"One may speculate that renal function influenced the association between serum Klotho concentration and HF...

"...Klotho concentration positively correlated with renal function, and eGFR was negatively associated with HF...

"...In our subgroup analysis with stratification by eGFR, the negative association between Klotho concentration and HF was nonsignificant in patients with eGFR < 60 ml/min/1.73 m2"

OK, so very possible that at least a large part of these findings are mediated by renal function.

For more about klotho and exercise:

https://twitter.com/nick_krontiris/status/1584182857601548288

Association between serum klotho concentration and heart failure in adults, a cross-sectional study from NHANES 2007–2016

doi.org/10.1016/j.ijca…

#exercise #Workout #TrainHard #GymLife #GymTime #muscle #strength #lift #GetStrong #cardio #hiit