Here, the consumption of caffeinated coffee was inversely associated with the risk of type 2 diabetes among US nurses with a history of gestational diabetes, with higher intakes being associated with a more favorable glucose metabolic profile among the type 2 diabetes-free women.
A few other notable findings:
- "This current study presents complementary findings on the inverse associations of coffee, particularly caffeinated coffee, with T2D progression for high-risk individuals with a history of GDM...
- "...However, our observation on the null findings for decaffeinated coffee was in contrast to the literature evidence, possibly due to the overall low consumption levels in this cohort...
- "...We also noted a stronger inverse association of caffeinated coffee in an earlier follow-up period, which may possibly be due to an increased risk of T2D with age and altered T2D risk in the context of other major risk factors that may have changed over time."
- "Substituting the consumption of various beverages with total coffee was associated with a reduced risk of T2D...
"...Specifically, a hypothetical replacement of 1 serving/d of SSBs and ASBs with 1 cup/d of total coffee was associated with 16%... and 7% lower risk of T2D, respectively...
"...The replacement of 1 serving/d of SSBs and ASBs with 1 cup/d of caffeinated coffee was associated with 17%... and 9%... lower risk of T2D, respectively."
Habitual coffee consumption and subsequent risk of type 2 diabetes in individuals with a history of gestational diabetes – a prospective study

doi.org/10.1093/ajcn/n…

#MetabolicSyndrome #caffeine #coffee #Women #nutrition #diet

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More from @nick_krontiris

Nov 22
This systematic review and meta-analysis suggests that CoQ10 supplementation is likely to improve lipid profiles in adults, with the optimal dose being 400-500mg/day. Image
- CoQ10 supplementation is likely to decrease total cholesterol, LDL-c, and TG and increase HDL-c levels in the adult population.
- Dose–response analysis revealed an inverse J-shaped nonlinear pattern between CoQ10 supplementation and TC, in which the optimal dose was 400 to 500 mg/day.
Read 4 tweets
Nov 22
Using genome-wide association studies (GWAS) of large-scale whole-body MRI data, this one found substantial genetic correlations between body composition measures and a range of cardiometabolic diseases, with the strongest correlation between liver fat and type 2 diabetes. ImageImageImage
Note that where you see MV in the pic above, it's muscle volume, MF is muscle fat infiltration and AFR is Abdmonal Fat ratio.

I think this legend here is more useful, so there you go, for easier comparison/lookup: ImageImage
- "Our findings that a substantial portion of the genetic determinants of these measures are related to the immune system fit with a large body of literature... Image
Read 9 tweets
Nov 21
In this one, healthy postmenopausal women with a family history of type 2 diabetes did not exhibit altered substrate metabolism or oxidation during submaximal exercise nor in the immediate period after exercise.
Therefore, this data suggests that the metabolic defects previously observed in family history of type 2 diabetes "might be limited to contexts where the action of insulin is preponderant...
"...and that exercise metabolism is spared in a healthy population of FDR (first-degree relatives)...
Read 5 tweets
Nov 21
This study in twins found that how effectively an individual awakens in the hours following sleep is associated with sleep quantity/quality the night before, physical activity the day prior, a breakfast rich in carbohydrate, and a lower blood glucose response following breakfast.
- Nights when an individual slept longer than their own typical sleep amount (rather than a standardised sleep amount), were associated with a superior (i.e., higher) degree of next-morning alertness.
- More than just sleep duration, however, sleeping later into the morning than is typical for a given individual (which in part, can give rise to longer sleep duration), predicted higher levels of alertness that following morning.
Read 13 tweets
Nov 21
This systematic review found that the majority of the literature suggests that individuals with both mood- and anxiety-related disorders and sleep disorders are likely to have lower heart rate variability during sleep.
- "This suggests that sleep-related ANS dysfunction may be a common but independent factor to both sets of disorders, and may be an underlying reason for the frequent co-occurrence of these conditions...
"...especially given that in healthy individuals, both poor sleep and lower sleep-related HRV are predictors of more severe psychological symptoms"
Read 4 tweets
Nov 21
This one found N-terminal pro-B natriuretic peptide (NT-ProBNP) to independently associated with all-cause mortality and mortality from cardiovascular causes, irrespectively of blood glucose levels, sex, age and body mass index in US adults aged 45–79 years.
- NT-ProBNP levels were associated with all-cause and cardiovascular mortality after a median follow-up of 13 years in people without a previous history of heart failure.
- The association remained consistent after adjustment for known cardiovascular risk factors and socio-behavioral factors.
Read 7 tweets

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