Mia Malan Profile picture
Dec 1 8 tweets 8 min read
🧵1. @SAHPRA1 says it’s “days away” from announcing a decision on the registration of the #HIV prevention jab, #CABLA. The shot virtually wipes out your chances of contracting HIV through sex + needs to be taken every 2 months. bit.ly/3ER7ejq#WAD2022
2. How does the jab work? A bit like contraception, says @LindaGailBekker. “U take contraception before sex 2 prevent pregnancy. Similarly, u take the jab before being exposed 2 #HIV 2 prevent infection.” Listen 2 Linda-Gail on @bhekisisa’s #HealthBeat. bit.ly/3FjBlS8
3. What makes #CABLA work? An antiretroviral drug called cabotegravir. Some people with #HIV use it for treatment, along with other #ARVs. The drug prevents #HIV from entering your cells. bit.ly/3ER7ejq
4. Will SA procure #CABLA? Most likely — if the price is right. How long will it be before this happens? If everything works out, the tendering process could start as soon as March (the tender process takes about 6 months, says @healthza). bit.ly/3ER7ejq
5. How soon could SA see a large-scale rollout of #CABLA? @healthza says by August 2023 — if drugmaker #ViiVHealthcare comes up with an affordable price in time. #WorldAIDSDay2022 bit.ly/3ER7ejq
6. How much can SA pay 4 #CABLA? Studies say we shouldn't pay more than 2x the price of #HIV prevention pills, which cost R60 per patient per month. So #CABLA should not cost more than R240/jab (R120/ month, so R240/jab because you take it every 2 months). bit.ly/3ER7ejq
7. When will #ViiVHealthcare announce a price for 90 poorer countries, including SA? There’s no date for that yet, and no guarantee it will be R240 per jab. ViiV’s Kim Smith explains it in our @bheksisisa_MG TV programme, Health Beat. bit.ly/3FjBlS8 #WorldAIDSDay2022
8. Has anyone in SA used #CABLA? Yes, trial participants have. Here what they've got to say via @yolandamdzeke and @KeMohale. #WorldAIDSDay2022

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More from @miamalan

Dec 2
🧵1. BREAKING: @SAHPRA1 has confirmed the registration of the #HIV prevention jab, #CABLA in South Africa. On Thursday, #ViiVHealthcare issued their statement. ImageImage
2. Who can use the jab? @SAHPRA1 didn't specify restrictions for use in their statement, only that it is "a highly effective option for people at substantial risk of #HIV infection." Image
3. How does the jab work? It uses an #ARV called cabotegravir that prevents #HIV from replicating and entering someone’s cells. It’s taken every two months. Read my latest story for more. bit.ly/3ER7ejq
Read 5 tweets
Sep 12
🧵1. @HealthZA will offer #COVID19 #Pfizer jabs 2 high-risk kids between 5 + 11 yrs on recommendation of the VMAC.

When? The #EVDS 1st needs 2 be updated, a circular needs to be issued + health workers need 2 be trained. Nicholas Crisp: "It will take at least a month."
2. What counts as a high-risk condition?
Chronic respiratory disease
Chronic heart conditions
Chronic conditions of the kidney, liver, digestive system
Immunosuppression
Endocrine disorders
Chronic neurological disease
Asplenia
Genetic abnormalities
3. Will SA buy pediatric #COVID19 formulations?
Not necessarily.

Crisp: "The demand will be very small and all controlled by medical practitioners so we'll try fractionation."

How does fractional dosing work? You take 1/3 of the adult dose (kids = 10µg, adult doses = 30µg ).
Read 5 tweets
Jun 27
[Thread] 1. SA saw its 1st confirmed #monkeypox case last week. Will there be more cases? YES. Why? The 1st case doesn’t have a travel history so he (a 30 year old man from Jhb) contracted it from someone in SA who already had it. bit.ly/3QNA7SH
2. How do you get #monkeypox? Through close contact, e.g. hugging, kissing, sex, or contaminated materials, e.g. shared linen or cutlery. It’s much harder to contract monkeypox than #COVID19. The @nicd_sa's Jackie Weyer explains it in this sound clip:
3. What’s the most telling #monkeypox symptom? Blisters on your skin. The blisters don’t have to be all over your body, they can, for instance, just be on your genitals, hands or face. The @nicd_sa's Jackie Weyer explains in this sound clip:
Read 10 tweets
Jun 23
[Thread] JUST IN:
1. @healthza has confirmed that #JoePhaahla has repealed regulations 16A, 16B + 16C in section 90 of the National Health Act. What does this mean?
In short:
1. No masks
2. #COVID19 gathering rules = dropped
3. COVID entry requirements into SA = dropped
2. What does regulation 16 A say?
- You must wear a mask indoors
- You must wear a mask when using public transport

This has been repealed, so you no longer:
- Have to wear indoor masks
- Have to wear masks when using public transport
3. What does regulation 16 B say?
- You need to be vaxxed 4 certain gatherings/produce proof you tested negative 4 #COVID19
- There are nr limits on people attending a gathering if = not vaxxed/test negative

This has been repealed, so these rules 4 gatherings = no longer valid.
Read 6 tweets
Jun 3
🧵JUST IN: 1. From Mon, 6 June, people of 50+ can get an extra #Pfizer #COVID19 vaccine booster 120 days after their previous booster. Technically, you can already get one from tomorrow (Sat), as the #EVDS went live tonight, but you’ll only receive an sms alert from Mon.
2. Can you choose if you want an extra #JnJ or #Pfizer booster? No. For this round, you'll need to take a #Pfizer booster (all SA’s #Pfizer jabs will have expired by the end of Oct, so this is one way of using them faster before then).
3. If you had #JnJ as a 1st dose:
- 2nd dose (JnJ/#Pfizer) = 60 days after 1st shot
- 3rd dose (booster, JnJ/Pfizer) = 90 days after 2nd dose
- 4th dose (booster, Pfizer, the one that kicks on Mon) = 120 days after 3rd dose Image
Read 8 tweets
May 18
🧵1. It used to be straightforward to determine when we were in a #COVIDinSA wave. Everyone used the ministerial advisory committee’s formula. In 2022, things are a bit more complicated. Some researchers argue this method is no longer all that useful. bit.ly/3wkRRwv
2. If we use the MAC formula, the fifth wave started on May 7. But since these numbers alone no longer translate into curfews, lockdowns or liquor bans, @nicd_sa researchers believe a new benchmark may be necessary. bit.ly/3wkRRwv
3. The @nicd_sa's @Dr_Groome says #COVID19 case numbers have become less meaningful — using them to calculate a wave, even more so: “Severe outcomes like hospitalisations and deaths are better metrics to use now that we have seen the decoupling of cases and severe outcomes.”
Read 18 tweets

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