Mia Malan Profile picture
Dec 2 5 tweets 5 min read
🧵1. BREAKING: @SAHPRA1 has confirmed the registration of the #HIV prevention jab, #CABLA in South Africa. On Thursday, #ViiVHealthcare issued their statement. ImageImage
2. Who can use the jab? @SAHPRA1 didn't specify restrictions for use in their statement, only that it is "a highly effective option for people at substantial risk of #HIV infection." Image
3. How does the jab work? It uses an #ARV called cabotegravir that prevents #HIV from replicating and entering someone’s cells. It’s taken every two months. Read my latest story for more. bit.ly/3ER7ejq
4. How soon will we see #CABLA rolled out in SA? @HealthZA says it could be within 9 months (Aug 2023) — but only if the price is right. Watch @Bhekisisa_MG’s 3rd #WorldAidsDay2022 edition of #HealthBeat for more. bit.ly/3VIOPvZ
5. NEW: According @SAHPRA1's CEO, Boitumelo Semete-Makokotlela, #CABLA is authorised for use in people who weigh 35 kilograms or more. It is not indicated for use in pregnant women, as “safety has not yet been sufficiently demonstrated in pregnant women”, Semete-Makokotlela says.

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More from @miamalan

Dec 1
🧵1. @SAHPRA1 says it’s “days away” from announcing a decision on the registration of the #HIV prevention jab, #CABLA. The shot virtually wipes out your chances of contracting HIV through sex + needs to be taken every 2 months. bit.ly/3ER7ejq#WAD2022
2. How does the jab work? A bit like contraception, says @LindaGailBekker. “U take contraception before sex 2 prevent pregnancy. Similarly, u take the jab before being exposed 2 #HIV 2 prevent infection.” Listen 2 Linda-Gail on @bhekisisa’s #HealthBeat. bit.ly/3FjBlS8
3. What makes #CABLA work? An antiretroviral drug called cabotegravir. Some people with #HIV use it for treatment, along with other #ARVs. The drug prevents #HIV from entering your cells. bit.ly/3ER7ejq
Read 8 tweets
Sep 12
🧵1. @HealthZA will offer #COVID19 #Pfizer jabs 2 high-risk kids between 5 + 11 yrs on recommendation of the VMAC.

When? The #EVDS 1st needs 2 be updated, a circular needs to be issued + health workers need 2 be trained. Nicholas Crisp: "It will take at least a month."
2. What counts as a high-risk condition?
Chronic respiratory disease
Chronic heart conditions
Chronic conditions of the kidney, liver, digestive system
Immunosuppression
Endocrine disorders
Chronic neurological disease
Asplenia
Genetic abnormalities
3. Will SA buy pediatric #COVID19 formulations?
Not necessarily.

Crisp: "The demand will be very small and all controlled by medical practitioners so we'll try fractionation."

How does fractional dosing work? You take 1/3 of the adult dose (kids = 10µg, adult doses = 30µg ).
Read 5 tweets
Jun 27
[Thread] 1. SA saw its 1st confirmed #monkeypox case last week. Will there be more cases? YES. Why? The 1st case doesn’t have a travel history so he (a 30 year old man from Jhb) contracted it from someone in SA who already had it. bit.ly/3QNA7SH
2. How do you get #monkeypox? Through close contact, e.g. hugging, kissing, sex, or contaminated materials, e.g. shared linen or cutlery. It’s much harder to contract monkeypox than #COVID19. The @nicd_sa's Jackie Weyer explains it in this sound clip:
3. What’s the most telling #monkeypox symptom? Blisters on your skin. The blisters don’t have to be all over your body, they can, for instance, just be on your genitals, hands or face. The @nicd_sa's Jackie Weyer explains in this sound clip:
Read 10 tweets
Jun 23
[Thread] JUST IN:
1. @healthza has confirmed that #JoePhaahla has repealed regulations 16A, 16B + 16C in section 90 of the National Health Act. What does this mean?
In short:
1. No masks
2. #COVID19 gathering rules = dropped
3. COVID entry requirements into SA = dropped
2. What does regulation 16 A say?
- You must wear a mask indoors
- You must wear a mask when using public transport

This has been repealed, so you no longer:
- Have to wear indoor masks
- Have to wear masks when using public transport
3. What does regulation 16 B say?
- You need to be vaxxed 4 certain gatherings/produce proof you tested negative 4 #COVID19
- There are nr limits on people attending a gathering if = not vaxxed/test negative

This has been repealed, so these rules 4 gatherings = no longer valid.
Read 6 tweets
Jun 3
🧵JUST IN: 1. From Mon, 6 June, people of 50+ can get an extra #Pfizer #COVID19 vaccine booster 120 days after their previous booster. Technically, you can already get one from tomorrow (Sat), as the #EVDS went live tonight, but you’ll only receive an sms alert from Mon.
2. Can you choose if you want an extra #JnJ or #Pfizer booster? No. For this round, you'll need to take a #Pfizer booster (all SA’s #Pfizer jabs will have expired by the end of Oct, so this is one way of using them faster before then).
3. If you had #JnJ as a 1st dose:
- 2nd dose (JnJ/#Pfizer) = 60 days after 1st shot
- 3rd dose (booster, JnJ/Pfizer) = 90 days after 2nd dose
- 4th dose (booster, Pfizer, the one that kicks on Mon) = 120 days after 3rd dose Image
Read 8 tweets
May 18
🧵1. It used to be straightforward to determine when we were in a #COVIDinSA wave. Everyone used the ministerial advisory committee’s formula. In 2022, things are a bit more complicated. Some researchers argue this method is no longer all that useful. bit.ly/3wkRRwv
2. If we use the MAC formula, the fifth wave started on May 7. But since these numbers alone no longer translate into curfews, lockdowns or liquor bans, @nicd_sa researchers believe a new benchmark may be necessary. bit.ly/3wkRRwv
3. The @nicd_sa's @Dr_Groome says #COVID19 case numbers have become less meaningful — using them to calculate a wave, even more so: “Severe outcomes like hospitalisations and deaths are better metrics to use now that we have seen the decoupling of cases and severe outcomes.”
Read 18 tweets

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