Thread by @DrTiffanyL

@redcell_doc talking about #SCT and #VTE in a #23andme cohort! Check it out here. #ASH22 1/n

@redcell_doc Sickle cell DISEASE has a unique reason for thromboembolism -- PE predominance - in situ or embolism from legs? Unclear still. But we know #SCT patients have higher D-dimer levels so maybe there's a hint for more in trait patients. #ASH22 2/n

@redcell_doc so, why not look into this diverse and high powered cohort? Did you know 80% of 23andme people consent to research cohort (caveat 90% of this cohort is from the United States)! #ASH22 3/n

@redcell_doc And of course, able to exclude patients with SCD (with SC, Sbeta+, etc) and those with FVLeiden and prothombin gene mutation -- because they had that data in 23andme! Quite the dataset. #ASH22 4/n

@redcell_doc 18,200 (!) carriers included -- see here that there is more PE than just DVT in the sickle cell trait carriers. In fact, no increased risk of isolated DVT, but 2 fold increase of PE (+/- DVT) compared to those without. #ASH22 5/n

@redcell_doc Their numbers were so large that you really can see how impactful this huge dataset was to show no overlap in confidence intervals. Loved this specific and useful slide. #23andme 6/6 #ASH22