Raj Rajnarayanan Profile picture
Dec 25, 2022 17 tweets 14 min read Read on X
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

16.1% BQ.1.1
13.8% XBB.1.5👀⬆️
11.3% BQ.1
6.4% BQ.1.22
4.3% XBB.1
2.2% BQ.1.1.4
2.0% BQ.1.1.3
1.9% BQ.1.2
1.9% BQ.1.3

Tracker: tinyurl.com/mryj4uu7

#OmicronUpdates 12/24/22
1/n Image
Sequence count by US State

New York has submitted a huge share of sequences with specimen collection dates in the last 15 days.

2/n Image
Granular details -#VariantDashboard #USA #15DayTrends

3/n Image
.@CDCgov updated variant proportions estimates on 12/23/2022 (CDC updates nowcast estimates every Friday)

Several BQ* are circulating at >1% & XBB.1.5* are good candidates to be included in CDC's Nowcast estimates next week!



4/n
The Great Convergence!

Tracked #VariantSoup with key #Spike mutations @ 346, 356, 444-446, 450, 452, 460, 486, 490, 493-494 positions

public.tableau.com/app/profile/ra…

5/n
Predicted Immune Escape and ACE2 binding of top lineages in USA (relative to BA.2)

Bivalent boosters (OG/Omicron.BA.5) will potentially protect the boosted from getting severe disease/hospitalizations.

Please get #boosted ASAP!

public.tableau.com/app/profile/ra…

6/n
#Hospital #Capacity - (by State/Division)

All hospitalizations not just COVID-19

public.tableau.com/app/profile/ra…

7/n
#COVID19 #Hospitalizations in the #UnitedStates

Please get #boosted (especially > 50 yr old and immune compromised) and #MaskUP!

Hospital Tracker (by States, by age group): public.tableau.com/app/profile/ra…

8/n
Status of the latest #COVID19 Wave in #NewYork #BellwetherState

XBB.1.5 is the top circulating lineage in NY

Top Lineages (#15DAYTrends):

XBB.1.5 (35.5%)👀🚀
BQ.1.1 (14.5%)
XBB.1 (9.1%)
BQ.1 (8.1%)
BQ.1.1.3 (2.4%)
BQ.1.11 (2.0%)
BQ.1.1.4 (1.9%)
BQ.1.14 (1.7%)

9/n ImageImage
Rise of highly immune evasive XBB* family of lineages especially XBB.1.5 (Key mutation: Spike F486P) in NY is concerning

fortune.com/well/2022/11/0…

10/n
BQ* Hotspots - #USA #15DayTrends

11/n Image
Recombinant lineage hotspots - #USA #15DayTrends

12/n Image
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #California

BQ.1 and BQ.1.22 are the top circulating lineage in CA

13/n ImageImage
A closer look at BQ.1.22....one of the top circulating lineages in #California

As of now, XBB.1.5 and BQ.1.1* are still the top dogs!

14/n Image
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #Massachusetts

XBB.1.5 is the top circulating lineage in MA

15/n ImageImage
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #Connecticut

XBB.1.5 is the top circulating lineage in CT

16/n ImageImage
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #NewJersey

XBB.1.5 is the top circulating lineage in NJ

17/n ImageImage

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More from @RajlabN

Jul 20
Tracking #SARSCoV2 #Lineages - Globally |07/20/24

Top lineages -#30DayTrends

KP.3.1.1 (14.2%)👀
KP.2.3 (7.9%)
KP.3.1 (7.8%)
KP.3.3 (7.7%)
KP.3.2 (3.8%)
KP.3 (3.4%)
KP.3.1.4 (3.4%)
KP.2 (3.4%)
LB.1 (2.7%)
KP.2.2 (2.7%)

Track #G30 :

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends KP.3* & KP.2* are the dominant group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 06/20/2024 (12,854 sequences)

2/n Image
@GISAID Thanks to all the countries that are still supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters: #USA #UK #Canada #Spain #Japan #Israel #France #Singapore #Netherlands #Australia #Ireland #Iceland #China #Sweden #Portugal #Italy

3/n Image
Read 19 tweets
Jun 19
#COVID19 #VariantDashboard - #USA | 06/18/24
#SARSCoV2 #Lineages #30DAYTRENDS

KP.2.3 (7.7%)
KP.2 (7.4%)
KP.3.1 (5%)
KP.3.3 (4.8%)
JN.1.16.1 (4.2%)
LB.1.7 (4%)
JN.1.16 (3.4%)
KP.1.1.1 (3.4%)
LB.1.3 (3.3%)
KP.2.2 (3.1%)
--
KP.3.1.1 (1.5%)👀


1/ntinyurl.com/mryj4uu7
You can filter spike mutations S31del, R346T, L455S, F456L, T572I (Top convergent mutations) to display #SLip, #FLiRT, #TiRT, #FLiRTTI, #DeFLiRT combo mutations; (Note: retired #FLip as of now)

Also, by state, lineage, collection date

2/n Image
#AirportSurveillance data - @CDCgov

Traveler Based Genomic Surveillance Program ( )

New: included "Travel history: Mediterranean Norwegian escape" use sampling strategy menu to display (a KP.5 and KP.2 is reported from WY)

3/n wwwnc.cdc.gov/travel/page/tr…
Image
Read 7 tweets
Jun 9
Tracking #SARSCoV2 #Lineages - Globally |06/08/24

Top lineages -#30DayTrends (#G30)

KP.2.3 (8.7%)
KP.2 (8.7%)
KP.3.1 (7.7%)
KP.3 (6.2%)
KP.3.2 (5.1%)
LB.1 (5%)
KP.1.1 (4.9%)

Track:

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends

KP.3* & KP.2* are the dominant group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 05/09/2024 (8,025 sequences)

2/n Image
@GISAID You can filter spike mutations S31del, R346T, L455S, F456L, T572I (Top convergent mutations) to display #SLip, #FLiRT, #TiRT, #FLiRTTI, #DeFLiRT combo mutations; (Note: retired #FLip as of now)

4/n Image
Read 15 tweets
Jun 5
#SARSCoV2 #VaccineAntigen Updates

Question before @US_FDA #VRBPAC committee:

For the 2024-2025 Formula of #COVID19 vaccines in the U.S., does the committee recommend a monovalent JN.1-lineage vaccine composition?

Watch:

1/n youtube.com/live/weaKQiFk_…
Image
Mutations of Interest on JN.1 background

JN.1 + F456L (FL) |JN.1.16 • JN.1.11.1
JN.1 + R346T (RT) |•JN.1.18 •JN.1.13.1 • KQ.1
JN.1 + R346T + F456L (#FLiRT) |•KP.2 • KP.1.1
JN.1 + R346T + F456L + T572I (#FLiRTTI) |• KZ.1.1.1
JN.1 + F456L + Q493E (#FLuQE) |• KP.3

2/n Image
from @Novavax presentation

JN.1 Vaccine Induces Broad Neutralizing Responses to All Subvariants Tested

3/n Image
Read 4 tweets
Jun 5
#SARSCoV2 Updates

KP.3 group of lineages (as of 6/4/2024) Image
KP.2 (JN.1.11.1 w/ S:R346T) group of lineages (as of 6/4/2024) Image
JN.1* group swells to 266 (not counting recombinants)
Read 4 tweets
May 18
Tracking #SARSCoV2 #Lineages - Globally |05/18/24

Top lineages -#30DayTrends (#G30)

KP.2 (12.7%)
KP.3 (11.6%)👀
JN.1.7 (6.9%)
JN.1 (6.8%)
JN.1.16 (5%)
JN.1.4 (4.9%)
JN.1.16.1 (4.6%)
KP.1.1 (3.6%)
KS.1 (2.8%)
JN.1.32 (2.7%)
LB.1 (2.7%)


1/npublic.tableau.com/app/profile/ra…
Granular details #Global #30DayTrends

KP* is the dominant group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 04/18/2024 (6,469 sequences)

2/n Image
@GISAID Predicted Immune Escape vs ACE2 Binding Scores of circulating SARSCoV2 lineages (Relative to BA.2)



3/n public.tableau.com/app/profile/ra…
Image
Read 7 tweets

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