"A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention." 🩸🧠
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Introduction
What is the use of biomarkers? 🧠
Diagnostic tool🪓
Tool for staging the disease 🥼
Indicator of prognosis📡
Predic or monitor of clinical response to an intervention🚨
Remember: "tools"should aid clinicians, not be the source of all truth.
DLB belongs to a family of disorders typically known as "synucleinopathies" 🔬
Other members are:
- MSA
- PD
- PDD
All of them have abnormal inclusions of α-Synuclein at a pathological level.
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⚠️⚠️⚠️
"Pathology is not pathogenesis", therefore we shouldn't assume that the presence of these pathological changes are a synonym of "protein toxicity".
⚠️Disclaimer:
Due to the complexity of this structure, this tweetorial is composed of three main parts.
1️⃣ Gross anatomy and microscopic anatomy (sort of)
2️⃣ Areas and connections
3️⃣ Clinical Syndromes and curiosities
Hope you enjoy!
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Do you remember last Tweetorial's question?
Exner's area 🧠📝🥸
Described in 1881, the area located close to the superior frontal sulcus in BA6, anterior to the hand primary motor area, has been involved in the handwritten production of words.
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