Discover and read the best of Twitter Threads about #Dementia

Most recents (24)

#CIIIEN2022 | Comienza la X Sesión Científica del Global Summit #NEURO2020/22.

Interviene Bruce Miller, investigador de la @UCSF

✅ "Frontotemporal #Dementia: Diagnosis to Treatment"


@Fund_CIEN #FundaciónReinaSofía @ciberned
#CIIIEN2022 | Presenta @sanchezvaller, investigadora de @hospitalclinic y de @idibaps.

✅ "Autosomal dominantly inherited dementias: from genetic counselling to early intervention"


@Fund_CIEN #FundaciónReinaSofía #NEURO2020/22 @ciberned
Read 4 tweets
#ParkinsonDisease is a movement disorder associated with

- motor symptoms
- cognitive impairment
- mental health disorders
- autonomic symptoms
- sleep disorders
- pain
- other sensory disturbances.

Learn more 👉…
#DYK❓ Globally, disability and death due to #ParkinsonDisease are increasing faster than for any other neurological disorder 👉
Up to 80% of people with #ParkinsonDisease may develop #dementia during the course of their disease 👉…
Read 5 tweets
Hot but not bothered?🧠🔥 Our paper on human brain temperature is out today in Brain! @ONeill_Lab @MRC_LMB @Brain1878 #LMBResearch #BrainTemp #BrainTrauma…
With thanks to our amazing participants, collaborators, and supporters @AriErcole @Etherjoe @ManuelCabeleira @CescaStats @EdinUniImaging @EdinUniNeuro @EdinUniBrainSci @CenterTBI @CellBiol_MRCLMB @RachelSEdgar and @The_MRC for funding
In a prospective analysis of healthy men and women, we found that brain temperature is higher than body temperature; brain temperature ranges from 36.1 to 40.9°C, with an average of 38.5C 🧠🔥.
Read 11 tweets
Excited to share our new paper out at @NatImmunol today! We discovered the limiting factor for #brain #Tregs is #IL2, and developed a new #genetherapy to treat #traumaticbraininjury and other #neuroinflammatory pathologies. 1/12…
The work started more than 10 years ago, after my brother Russell died following a #traumaticbraininjury. The more I read into it, the more treatable #neuroinflammation seems. Obviously there is a #brain delivery problem, but stopping #inflammation is basic #immunology! 2/12 Image
We had a great post-doc, @EmanuelaPasciu1, drive a project showing #Tcells in mouse and human brain, with key functions. Among these T cells were a small population of anti-inflammatory #Tregs, again in mouse and human. 3/12…
Read 12 tweets
“If the whole world was vaccinated tomorrow and we spent just three years ‘learning to live with COVID’ under the current [U.S. public health] strategy, we could have well over a billion people living with…
“It reminds me of patients with #dementia. These are patients in their 20s and 30s who were healthy before—former CEOs and CFOs who were high-functioning who are now scared about their ability to manage their livelihoods with their impairment.” #LongCovid
His advice: If your aim is both to survive COVID and avoid #LongCovid, “Mask and be mindful of the public settings you’re going to go in.”

“Good masks will keep you safe,” he says, referencing N95 masks.
Read 5 tweets
Today, @AsthmaIreland made a public statement in support of Minister @EamonRyan's proposed Solid Fuel Regulations. We called on all parties to support the regulations in a bid to end the 1,300 premature deaths caused annually by fine particle emissions from burning solid fuels.
The new regulations would ban smoky coal and wet wood, and prohibiting the commercial sale of sod turf, will save lives, but provide for continued turf extraction by those with turbary rights and distribution within small communities. @Dept_ECC
Air pollution can cause as well as exacerbate #chronicillness like #COPD, #asthma, heart disease and #stroke, #cancer, #diabetes and #dementia. Irish clinical research also links spikes in air pollution with increased hospital admissions for asthma and heart disease @roinnslainte
Read 10 tweets
#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner.…
#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA)…
Read 93 tweets
1- My current take on whether anti-amyloid therapies are likely to have meaningful impact on cognition, functioning & quality of life of people living w/ #dementia due to #Alzheimers disease:

Not likely.

For details, based on my recent Grand Rounds at Penn St, read on.
2- History:

After finding that active immunization with Abeta42 in mice that overexpressed APP resulted in virtual elimination of amyloid deposits, there was great enthusiasm for anti-amyloid therapies - and for the amyloid hypothesis.
3- More history:

Unfortunately, active immunization with Abeta42 in humans resulted in unacceptable side effects.

Passive immunization with various anti-amyloid monoclonal antibodies failed in multiple studies.

It seemed like this was the end of the line, until ...
Read 17 tweets
Daily Bookmarks to GAVNet 03/30/2022…
Houston, Dallas led metro area growth in 2021 even as their urban cores lost population…
#PopulationGrowth, #MetropolitanAreas, #UrbanDemographics
Read 13 tweets
At the age of 30, Georgie never expected that my dad might not know her name.

Her dad was diagnosed with dementia at just 46-years-old, this is her story.

'Dad was a hard-working air conditioning engineer and he loved his job but his long hours began to catch up with him.'

'For a better work-life balance, he became self-employed.'
'This transition led to bouts of unemployment and a squeezed income.'

'He struggled to keep up with the paperwork; the people he worked for grew increasingly concerned about his performance.'

'Little did I know these were the early stages of dementia.'
Read 13 tweets
1/🧵Important = Brain Injury in #COVID💥
📍N=251 hospitalized COVID pts had biomarkers of neurodegeneration (dying brain cells).

📍Previously healthy COVID pts had ⬆️er levels than Alzheimer’s pts!

How do we understand this?
Hint: #Vaccinate yourself
2/ These elevated brain biomarkers indicate disease to different types of brain cells (eg, astrocytes, glial cells, neurons) in COVID patients. These were early unvaccinated pandemic patients. Vaccinated people will be less prone. WHY?
3/ There isn’t a ton of brain invasion by COVID. We think most of the 🧠 injury is INDIRECT. Meaning downstream injury from 1. upstream inflammation 2. blood clotting & 3. heavy sedation causing #delirium, which we proved to be a #dementia risk factor!
Read 7 tweets
1/🧵 Brain + Body damage in #COVID & Critical Illness
Sepsis -bacterial, viral, fungal- can cause rapid-onset #dementia. Finishing this test should be easy at her age but Millions of brain cells are damaged!

Protect yourself & others: #Vaxx + #Mask

H/T @trishla_17 for helping
2/ Our brain depends on a delicate balance of blood flow, nutrients & oxygen. When someone gets critically ill w #Covid or from other causes, that balance is dramatically disrupted. Small blood clots, dropping oxygen levels cause 🧠 damage.
3/ It’s odd to me that people don’t see severe COVID as a form of VIRAL SEPSIS. Sepsis is when infection of any kind causes your organs to begin to fail – lungs, brain, heart, kidneys.  It’s EXACTLY what we see day-in day-out in the COVID ICU.
Read 6 tweets
ما هو #الخرف؟

هل هو مجرد نسيان؟

هل #الزهايمر هو ذاته الخرف؟

وهل يتم تشخيصه بتحاليل/أشعة طبية؟

هنالك الكثير من الخلط بما يخص الخرف بلا شك المختصين لهم دور فيه حيث تم تغيير مسمياته عدة مرات اخرها في ٢٠١٣.

سنجيب عن هذه التساؤلات في هذه السلسلة @CogNeuroKSA @SaudiAlZheimer ١/١٢
الخرف #dementia مسمى يصف مجموعة من أمراض الانتكاس العصبي والزهايمر احدى انواعه

يتصف بتدهور عقلي ليس فقط بالذاكرة ولكن قد يؤثر على التفكير والسلوك والقدرة على أداء الأنشطة اليومية

على الرغم من أن الخرف يؤثر بشكل أساسي على كبار السن إلا إنه ليس جزءًا طبيعيًا من كبر السن. ٢/١٢
يصيب الخرف ٢٠٪ من الأشخاص فوق ٨٠ سنة، و ٤٠٪ من هم بعمر ٨٥ سنة وأكبر

بفضل الله ثم تطورات الطب الحديث ازداد عدد السكان بعمر٨٠ وما فوق من ١٪ في ١٩٠٠م إلى ٤٪ من إجمالي عدد سكان العالم حالياً،

وبذلك ارتفعت عدد إصابات الخرف اليوم الى ٥٥ مليون والمتوقع ان تصل ١٣٩ مليون في ٢٠٥٠م

Read 15 tweets
Daily Bookmarks to GAVNet 12/01/2021…
Drinking tea and coffee could lower your risk of stroke and dementia, study suggests…

#caffeine #consumption #coffee #tea #dementia #stroke #ResearchStudy
Read 11 tweets
Lifestyle habits which can be bad for your brain health.
While the condition is primarily caused by physical changes to the brain matter, heavily dependent on one's age, genetic risk, family history or if injuries to the brain, the kind of lifestyle you lead, dietary deficiencies may also increase one's chances of developing dementia.
If there is one single factor which can increase your chances of cognitive decline, poor brain health and accelerate ageing, it has to be the lack of Vitamin B12 in our diets.
Read 9 tweets
🌟Do you write behaviour support plans #BSPs for children/adults with #disability #dementia #ABI #ASD in Aus? We want your input! Research @FlindersCNHS
15min survey:…
Chance to win iPad🙏Please Share! Closes20Dec21 #BSPractitionerSurvey @ApbsAus @AustPsych
🌟Do you write behaviour support plans #BSPs for children/adults with #disability #dementia #ABI #ASD in Aus? We want your input! Research @FlindersCNHS
15min survey:…
Chance to win iPad🙏Please Share! Closes20Dec21 #BSPractitionerSurvey @auaba2014 @theAPBS
🌟Do you write behaviour support plans #BSPs for children/adults with #disability #dementia #ABI #ASD in Aus? We want your input! Research @FlindersCNHS
15min survey:…
Chance to win iPad🙏Please Share! Closes20Dec21 #BSPractitionerSurvey @DevelopmetalEdu
Read 7 tweets
1/🧵For months I’ve been grappling with what seemed like a real gap in conversations about #LongCOVID.

Here in @STATnews, I introduce you to 30 references & 3 #COVID survivors – Ray, Pam, and Carolyn – who taught me a lot. I hope you think so, too…
2/ "I feel like I'm getting the silent treatment & it's killing me," #LongCOVID pt Pamela Bishop confided in me about her months-long interactions as she tried to get answers about a strange array of symptoms that have plagued her since recovering from #Covid19.

Pam then & now…
3/ Up to1 in 3 COVID survivors report experiencing #longCovid symptoms 3 to 6 months later. Their stories give me an extreme case of déjà vu because this is playing out similarly to the problem of long-term survivorship after non-COVID critical illness.
Read 26 tweets
Today is World Hospice and Palliative Care Day!

DYK❓ Over 5⃣5⃣ million people around the 🌐 are in need of #PalliativeCare but only 12% of the global need is met.

Access to palliative care services is a human right to health 👉
When life is threatened by serious illness such as

🚨 heart failure,
🚨 cancer,
🚨 chronic lung diseases,

#PalliativeCare offers comfort & solutions to improve physical and mental well-being of patients & their loved ones.

More info 👉…
#PalliativeCare helps relieve suffering and improve quality of life for patients and families dealing with serious illnesses through

✅ practical help
✅ medicines
✅ spiritual and emotional support

More info 👉
Read 12 tweets
Today is #WorldAlzheimersDay!

A timely and accurate diagnosis is 🗝️ to providing better care for people with #dementia. Yet, many people around the world don't have access to diagnostic services.

More data on dementia 👉
#Dementia is not an inevitable consequence of ageing.

More support is needed for people w/ dementia, in

✅ primary health care
✅ specialist care
✅ community-based services
✅ rehabilitation
✅ long-term care
✅ palliative care.

👉 #WorldAlzheimersDay
👥 Carers of people with #dementia also need support.

WHO's iSupport for dementia is a free skills and knowledge training that teaches family members and friends how to better support someone with dementia.

Click here 👉 #WorldAlzheimersDay
Read 4 tweets
#Dementia is currently the 7⃣th leading cause of death, affecting more than 5⃣5⃣ million people worldwide.

Here's why we should care about dementia 👉
With a growing number of people living with #dementia, countries need to step up & put in place a national policy, strategy or plan for supporting people with dementia & their families.

🆕 WHO's dementia global status report explains 👉
The disability associated with #dementia is a key driver of costs related to the condition.

In 2019 alone, the global cost of dementia was estimated to be USD1.3 trillion. More info 👉
Read 8 tweets
A reminder that all shops in NSW are currently required by law to have an alternative digital sign in sheet for those unable to use the QR code. Image
Many people may have cognitive (or physical) limitations which prevent them from using QR codes. Or they may lack the financial resources to own a smartphone.
People with #dementia for example may be unable to check in this way due to having difficulty learning new things.
Read 7 tweets
1/🧵Wake-Up to how #SLEEP flushes waste from your brain 🧠 @JAMA_current
I may get more done when I 💤 less, but I lose the long-game! #Evolution dictated that we gain an advantage by spending 1/3rd of our lives asleep.

I’ll tell you WHY?

2/ Why do we sleep? Brain rest? To process bad decisions or incomplete conversations? Maybe. But the coolest reason is removal of #amyloid & #tau proteins that cause #dementia. Our #glymphatic system does this most efficiently during deep sleep.
3/ Have I mentioned that I’m fascinated by the glymphatic system? It’s the lymph system for our #brain & serves as the “garbage” removal program to keep our #neurons healthy. Wanna know more?
Read 12 tweets
Today, our family followed through on the decision to move dad to a long-term facility in Mississauga. He's been on a dementia journey for about 8 years alongside a cancer one that has him also receiving palliative care. /2
The script flipped for me was a few years back when his conscientious nature had him scaling an aluminum ladder in a rainstorm to check that the eaves were clear ensuring we wouldn't have any flooding. Both his physical and mental capacity at the time put him at risk. /3
Read 20 tweets
1/ 🎥🧵 How do we test someone for #delirium in #COVID19 or any ICU? When someone won’t engage it can be a huge red-flag for “quiet” delirium, which predicts 3X ⬆️ #DEATH by 6 mo & acquired #dementia. Watch this movie of me testing pt #1 for delirium.

#MedTwitter #NurseTwitter
2/ What does this mean? He starts out OK but then can’t follow my command to squeeze only on the letter A. Instead, he squeezes when I say the word “squeeze” & doesn’t relax his grip or vary it on different letters. This is inattention & a cardinal feature of #Delirium.
3/ 🎥 Contrast Pt 1 with this Pt 2 video of me doing the same test. This person had delirium on earlier days & is now improving. He gets 8/10 correct responses, which means he’s attentive and not delirious any more. This day he walked & talked for the 1st time!

#Recovery #nurse
Read 7 tweets

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