Defining what "dysfunction" means is difficult and has been a challenge to scientists; it can mean very different things in different research studies. 🧵
The same can be said for cars. If a car is “dysfunctional,” what does that mean? It could mean that the engine sputters when traveling down the highway.
It could mean that a tire is flat, and the car can’t move along the road as easily. It could mean that the lights and the turn signals aren’t working.
Those are all different problems with a car. They all result from different causes. But here’s an important point: Regardless of what is wrong with the car, if it’s on the highway with any of those problems, it will affect the other cars on the road.
It will be more likely to slow down traffic or cause an accident. Traffic can slow or completely stop. The highway could “stop working” due to one car.
In reality, the overwhelming majority of car accidents aren’t about the cars but about the drivers of the cars. Drivers can also be “dysfunctional.” They can be on their cell phones. They can fall asleep at the wheel. They can be drunk. They can be high. They can have road rage.
Regardless of the cause of the dysfunction, whether it’s the car or the driver, these wayward cars and drivers affect traffic in similar ways.
Mitochondrial dysfunction is the same. It can be caused by many different things and can result in different problems for the mitochondria and for the cells in which they reside. #BrainEnergybrainenergy.com
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Mitochondrial dysfunction is the term most frequently used to describe impairment in mitochondrial function. 🧵
The diseases and illnesses that have been associated with mitochondrial dysfunction are widespread, and the list includes almost all of the psychiatric disorders.
It also includes the metabolic and neurological disorders such as obesity, diabetes, cardiovascular disease, Alzheimer’s disease, epilepsy, many cancers and Parkinson’s disease, and more…
In your body, energy needs to be produced in the right amount, in the right place, at the right time, and it goes through an unimaginably fast recycling process that involves #mitochondria.
The #mitochondria that aren’t moving appear to stay in places where things are always happening—either near factories where proteins are made (ribosomes) or synapses where there is a lot of activity, which is a very important fact relevant to how the #brain functions.
Researchers looking at #braincells under #microscopes have known for decades how to identify where the synapses are—they look for the mitochondria.