#TheRats [THREAD]

THE ULTIMATE PR OOF THAT #Pfizer/#BioNTech NEVER DEMONSTRATED THEIR #COVID19 "VACCINES" ARE SAFE OR EFFECTIVE, AND HOW HEALTH REGULATORS AROUND THE WORLD COLLUDED WITH THEM.

By Ehden Biber

This image holds the clue to what you are about to discover:

/1 Image
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As you saw in the (sanitised) image above, humans seem to have a different expression of something. But of what? and what does it had to do with #Pfizer/#BioNTech experimental gene therapy, known as #BNT162b2/#Comirnaty/#tozinameran?

Let's find out.

#TheRats
3/
#Pfizer/#BioNTech didn't conduct many safety tests on animals prior to them receiving their Emergency Usage Authorization.
Genotoxicity & carcinogenicity studies were not performed, because "The…vaccine formulation…(was) not expected to have genotoxic potential".
🤨
#TheRats Image
4/
#Pfizer/#BionTech DID NOT perform dedicated local tolerance tests, which are CRUCIAL tests that checks whether medicinal products are tolerated at sites in the body that may come into contact with the product as a result of its administration in clinical use.

#TheRats Image
5/
However, #Pfizer/#BionTech stated that "the assessment of local tolerance was performed in repeat-dose toxicity studies" and that the only thing they saw was oedema.

We will be back to this statement soon.

#TheRats Image
6/
#Pfizer/#BionTech didn't perform ecotoxicity / environmental risk assessment. The 2019 version of the NIH Guidelines on Research Involving (m)RNA Molecules lacked an appendix w/specific guidance on it, and it was a guidance, NOT a requirement.
advarra.com/resource-libra…

#TheRats Image
7/
#Pfizer/#bionTech didn't perform safety pharmacology studies.

They claimed it is "not considered necessary according to the WHO guideline (WHO, 2005)", which refers to a WHO guideline on nonclinical evaluation of vaccines, WHO Technical Report Series, No. 927, 2005.

#TheRats
8/
According to this guidance, the testing of #Prizer/#BionTech "vaccine", a product that had no prior nonclinical and clinical experience, was "expected to be more extensive than for those vaccines previously licensed and used in humans".

web.archive.org/web/2018051415…

#TheRats Image
9/
#Prizer/#BionTech got exemption using the pink highlighted text from page 55 in the WHO 2005 guide, according to "The Vaccine: Inside the Race to Conquer the COVID-19 Pandemic" by Joe Miller, Özlem Türeci & Ugur Sahin.

But…compare page 55 & what #BionTech claimed!

#TheRats ImageImageImage
10/
So … that was the list of the tests that #Prizer/#BionTech DID NOT perform.

Now, let's look at the tests they did perform, which they submitted to the regulators as a proof of the efficiency and safety of their product.
Here it is where it gets REALLY interesting.

#TheRats
11/
#Prizer/#BionTech performed immune and cellular immune response tests on 2 types of lab animals:

1) Mice: BALB/c mice (type of a lab mice) were used for "pharmacological animal model studies" and "for RNA-based vaccine development".

#TheRats Image
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#Prizer/#BionTech also used monkeys for the immune and cellular immune response tests:

2) rhesus monkey - the "non-human primates were chosen as they are a higher-ordered species, more closely related to humans, which may better reflect immune responses in humans"

#TheRats Image
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According to #BioNTech/#Pfizer EMA submission "The choice and relevance of the mouse for pharmacological animal model studies was based on the in-depth knowledge about the suitability, dosing and immunization regimen of BALB/c mice for RNA-based vaccine development".
#TheRats Image
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#Pfizer/#BioNTech "in accordance with the…WHO…guidance documents on nonclinical evaluation of vaccines (WHO, 2005)…(used) The Wistar Han (WH) rat (who) developed an antigenspecific immune response following BNT162b2 vaccination".

#TheRats Image
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In total, #Pfizer/#BioNTech submitted four pharmacology studies in the pre-clinical phase: two studies (R-20-0085 and R-20-0112) involved mice, one (VR-VTR-10671) used rhesus macaques, and the fourth study (20-0211) was an in vitro study.

#TheRats Image
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Mice:
#Pfizer/#BioNTech injected 8 female mice with 5μg of BNT162b2 intramuscular (IM), and showed an IgG antibody response to the receptor-binding domain (RBD) and the S1. They showed immune response, not that their "vaccine" can protect from #SARSCoV2.

#TheRats ImageImageImageImage
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mice (cont.):
#Pfizer/#BioNTech stated that on day 28, the immunization showed IgG binding affinity of KD 12nM to the S1 OR 0.99nM binding affinity to the receptor-binding domain (RBD), or how well does the body's IGG attaches to parts of the spike (lower is better).
#TheRats Image
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This Kd value depend on HOW #Pfizer/#BioNTech measured it! It is dependant on the concentration regime under which the reported Kd values were measured, and the time they waited to measure it!

They can cheat by using a "Titration regime"!

elifesciences.org/articles/57264

#TheRats
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"Titration regime" is when you have so much spike, that even with small immune response (IgG) will give a better Kd because there is higher chance of binding, which #Pfizer/#BioNTech could have used if they wanted to show high binding affinity, and didn't had one.

#TheRats Image
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#Pfizer/#BioNTech stated a binding affinity of KD 12nM to the S1 vs 0.99nM binding affinity to the receptor-binding domain (RBD). It meant that their product was way LESS effective in binding to the S1 vs. the RBD. Now, why is it important?
#TheRats
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It's important because immune response (IgG) was much more likely to bind to the RBD of a #SARSCoV2 than the spike itself, which CREATES NEUTRALIZATION ESCAPE VARIENTS, which #Pfizer/#BioNTech KNEW SINCE 2014! The S2 was MUCH better choice!

ncbi.nlm.nih.gov/pmc/articles/P…

#TheRats ImageImage
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The Delta variant of #SARSCoV2 had 2 RBD mutations, and the omicron had 15 RBD mutation vs the original "wild type" Wuhan "virus". It greatly impacted the binding affinity (Kd), which #Pfizer/#BioNTech knew would happen, therefore they chosen to use the S1 ($$$)!

#TheRats
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#Pfizer/#BioNTech performed their assessment on Spleen and lymph nodes. They never assessed the lungs immune response, which is what I thought you suppose to prove if your product is supposed to stop infection and spread of a respiratory infectious disease.
#TheRats Image
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A small note - I will not cover #Pfizer/#BioNTech vitro experiment. I also decided to exclude the topic of the lipid nanoparticle because it is too technical for most people. Perhaps in another thread on the topic.
Why? Because…
#TheRats
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THIS IS NOT THE END OF THIS THREAD!
In the next part I will go over the rest of the animal experiments. I know it's long, but you'll understand why really soon! I promise!
Don't forget to use the "Show replies" if the thread seems to have stopped abruptly 😊
#TheRats
26/
Welcome back to #TheRats, the story of how #Pfizer/#BioNTech never proved the safety or efficiency of their #COVID19 "#vaccines", and how the regulators helped them to do so.

(I had to add this because Twitter only allows to post 25 tweets at a time).

#TheRats
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Pfizer used Rhesus macaques monkeys in VR-VTR-10671, to prove immunogenicity. #Pfizer/#BioNTech claimed "at least an order of magnitude higher after BNT162b2 immunization of rhesus macaques than for the panel of SARS-CoV-2 convalescent human sera".
Sound impressing.

#TheRats
28/
#Pfizer/#BioNTech's "SARS-CoV-2 convalescent human sera (serum)" is SARS-CoV-2 neutralizing antibodies in sera from recovered COVID-19 patients.
Here is article that describes the experiment, and below you can read what they got.

nature.com/articles/s4158…

#TheRats Image
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#Pfizer/#BioNTech compared the geometric mean concentrations of RBD-binding IgG of the monkeys, 23,781 U ml−1 (30-μg dose level) for BNT162b2, to the RBD-binding IgG levels of a panel of 38 SARS-CoV-2-convalescent human serum, which was 602 U ml−1.

More is better?
#TheRats Image
30/
Not. Having too many antibodies in your body is not a good thing, and #Pfizer/#BioNTech knew about it, as well as everyone who knows anything about the immune system.

A value of 600 seems normal based on the following research:
journals.asm.org/doi/10.1128/sp…

#TheRats Image
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It's worse. In mice, 5μg of BNT162b2 created geometric mean concentrations of RBD-binding IgG of 434,560.
#Pfizer/#BioNTech decided that an immune concentration 40 times stronger in monkeys and 721 times stronger in mice then what humans had, is a good thing. Why?
#TheRats Image
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Last point - #Pfizer/#BioNTech used 2 to 4 year old monkeys. Macaques average age span is 25 years. This means they took, in human years, a 6 to 12 years old, and assumed it will work the same for adults with an immune system which very different in its capacities?
#TheRats
33/
#Pfizer/#BioNTech claimed their product (BNT162b) elicited protection in macaques, but they used the six monkeys that had been immunized using 100μg BNT162b2, not the 30μg (which was the dosage submitted to approval).
Perhaps the protection was not good enough?
#TheRats
34/
So finally, we come to the rats!

#Pfizer/#BioNTech conducted 3 experiments on rats.

#TheRats Image
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#Pfizer/#BioNTech conducted "two general/repeat-dose toxicity studies involved IM exposure of Han Wistar rats to BNT162b2 for a total of 17 days (three weekly administrations) followed by three weeks of recovery".

17 days does not seem like a lot, doesn't it?

#TheRats
36/
Well, because it is not. According to the creators of the "vaccine" (see #9), #Pfizer/#BioNTech shortened the timeline from 3 weeks between each shot, the schedule for humans, to one week. I enclose the relevant paragraph from the book.

#TheRats Image
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The repeat dosage toxicity was done using two formulas of #Pfizer/#BioNTech "vaccine", V8 and V9. V9 was the one approved, yet they still used the data from V8 as part of their submission. The difference? Codon Optimization (see #COptiGate).
No one cared.
#TheRats Image
38/

The redacted "INVESTIGATOR’S BROCHURE" pages 37 to 50 gave more details about experiments 38166 & 20GR142:
tga.gov.au/sites/default/…

Sasha Latypova's review on the topic (which I only discovered after finishing my analysis) is here:
home.solari.com/review-of-pfiz…

#TheRats ImageImageImage
39/
Last point, there is the #Pfizer/#BioNTech "Combined Fertility and Developmental Study in the Wistar Rat GLP Study", which I will not go into it, because it is time to unveil the real secret.
Remember the image from the beginning of the post? Allow me to remind you:
#TheRats Image
40/
AS you can see below, the still-slightly-sanitised image describe differences between human, mice, and rats. It is obvious just by looking at the image that mice has much less expression and rats seems to barely have any expression of something.

But what is it?

#TheRats Image
41/
The answer is: #ACE2.

ACE2 is the receptor used by #SARSCoV2 RBD, and as you can see the ACE2 receptors of humans, mice, and especially rats, responds VERY differently.

Did #Pfizer/#BioNTech knew about it? As you will see in the next post, they did... SINCE 2004!

#TheRats Image
42/
Scientists who studied SARS-CoV, including ones in #Pfizer/#BioNTech, knew that "Infection with S protein-pseudotyped retrovirus (W/SARS-CoV S protein) is less efficient in cells expressing rodent ACE2 than in those expressing human ACE2".

ncbi.nlm.nih.gov/pmc/articles/P…

#TheRats ImageImageImageImage
43/
I believe #Pfizer/#BioNTech, who wanted to get the emergency use authorization (EUA), has designed their experiments to use animals that they knew would have a very low chances of having severe adverse response to the spike protein created by their "vaccine".

#TheRats
44/
I believe #Pfizer/#BioNTech used rhesus (rh) macaques because they "do not usually develop SARS after SARS-CoV infection…Rh-ACE2…is more polymorphic than hu-ACE2…and did not support viral entry effectively".

It was known since 2008.

#TheRats
ncbi.nlm.nih.gov/pmc/articles/P…
45/
#Pfizer/#BioNTech also used Vero E6 cells to make the #SARSCoV2 inoculum for the monkeys, but "compared to SARS-CoV, SARS-CoV-2 generated higher levels of intracellular viral RNA, but strikingly ABOUT 50-FOLD LESS INFECTIOUS VIRAL PROGENY".

#TheRats
microbiologyresearch.org/content/journa… ImageImage
46/
I BELIEVE #Pfizer/#BioNTech DESIGNED THEIR EXPERIMENTS USING ANIMALS THAT WERE NOT FIT FOR PURPOSE.

1) Rat got injected with the "vaccine".
2) The lipid nanoparticles (LNP) penetrates the rat's cells. spike is being transcribed, translated and leave the cell.

#TheRats
47/
3) The spike proteins barely binds to rats ACE2 receptors; the vast majority of them do not penetrate organs with ACE2 receptors (e.g. heart).
4) The rats body starts to create huge amount of spike-RBD-binding IgG, trying to get rid of the free spikes.
#TheRats
48/
5) The "lonely" spike proteins (who don't have an ACE2 to bind to) can be problematic floating around (especially when it S2P structure is unstable, leading to disease prions), but it is better than the damage the spike is doing to the cells (e.g. mitochondria).

#TheRats Image
49/

6) It is plausible #Pfizer/#BioNTech used lab animals that #SARSCoV2 is barely able to infect or make sick, exposed them a lower infectious viral load, and used a form of "Titration regime", so they could "demonstrated" their product is "safe" and "effective".

#TheRats
50/
7) DOSAGE: if my understanding is correct, the impact of what I described is that THE DOSAGES #Pfizer/#BioNTech SUBMITTED FOR APPROVAL ARE UNSAFE, and that their own tests results indicates that.

In the next few posts, I will try to explain my concern.

#TheRats
51/
Dosage (cont.):
If #Pfizer/#BioNTech made their calculations based on animal models that did not include ACE2 differences, the immune response they were looking for could only have been created using a high dosage of the "vaccine" to compensate the ACE2 differences.

#TheRats
52/
Dosage (cont.):
Think of a rat ACE2 as "underperforming". If #Pfizer/#BioNTech rely on ACE2, one approach will be to try to give a higher dosage of the product, to increase the chances of interaction in the rat body, to improve probability.

#TheRats
53/
The impact of such flooding (for the rat) is more activation of its immune system without a massive damage due to the spike->ACE2 "underperformance". The higher dosage that might work for the rat, but for someone else (human) it would overflow the ACE2 in their body.
#TheRats
54/
There has been a lot of research & development of mice with a human ACE2. Here is one example. But #Pfizer/#BioNTech didn't had the time to get such animals, so, like with Codon Optimization (#COptiGate) they just didn't acknowledge it.

#TheRats
genengnews.com/news/covid-19-…
55/
In their submission to EMA #Pfizer/#BioNTech stated that "Rhesus macaques share a 100% homology with the human ACE2 sequence that interacts with the RBD of the S protein. BNT162b2".
Homology = having common ancestor.
It doesn't mean 100% match. It was a deception.
#TheRats ImageImage
56/
#Pfizer/#BioNTech only performed one biodistribution studied in rats (185350), and the limited it to the lipid nanoparticles. Rats ACE2 is so different that SARS-CoV infections were almost like a "background nose".

#TheRats
57/
Now that we know #Pfizer/#BioNTech failed to show safety or efficiency, EVERY ORGAN OF THE BODY that appeared in the biodistribution list is likely to have been harmed by the shots due to overdose, with higher risk to ACE2 enriched organs (e.g. heart).

#TheRats
58/
Which bring me to another "fun fact":
Do you know how many people were treated with #BioNTech experimental gene therapies, before #Pfizer got into the COVID19 business with them?
During 8 year… 400 cancer patients.
ZERO background in treating infectious diseases.

#TheRats ImageImageImage
59/
Hi everyone!
I am taking a short break, and then will add the next chapter in the story about #TheRats: #Pfizer/#BioNTech and "our" regulators.

Please share the 1st post, and if you can, tag people, and make it as viral as you can.

Thank you.
Ehden
60/
Dear all,
I promised to write about the connection between #TheRats, #Pfizer/#BioNTech, and the regulators. It will come soon.

For the last 24 hours I've been extremely busy trying to understand something I discovered about the experiments that doesn't make any sense to me.
61/
I reached out to few experts. The minute they confirm my understanding (or what happened), I will share it with you.
The reason I decided to focus on this rather than just write about the regulators is because there is a HUGE importance to these animal experiments.
#TheRats
62/
Because #Pfizer/#BioNTech performed such a small amount of animal trials, any irregularity, bad design, missing information, etc. should have been picked up by health regulators, and yet, no one said a word, on the contrary.

I am here to expose #TheRats.
Thank you all,
Ehden
63/
Here's a little prequel:
Do you know how many rounds of RT-qPCR #Pfizer/#BioNTech used to "identify" a #SARSCoV2 positive animal? 45 cycles !!!

If Kary Mullis was alive he would have destroyed these "scientists".

These were not scientific experiments, but a hoax.

#TheRats

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