The biggest giveaways are in the solid dosage forms & dosing patent, which includes trial designs for peripherial diabetic neuropathy & bunionectomy as examples.
"Phase I trial, which involved 70 healthy adults, showed that obeldesivir reached sufficient concentrations in the blood and supports taking it without regard to food"
Patent on oral GS-441524 prodrugs has 1st priority filing on AUGUST 27, 2020. So they did not think the '524 hypothesis was worthless in 2020. 2/16 statnews.com/2020/05/14/gil…
Context: @Muller_Lab & I published an Opinion in @statnews urging Gilead to pursue dev of #GS441524 in May 2020 (above)
On June 24, 2020, we first met w Gilead science leadership, who indicated they were not interested. 3/16 medium.com/@victoriacyani…
Chinese patent by the WIV first filed in Sept 2020. WO patent filed in April 2021. Gilead's 2009 patent on 524 and the 2016 patent on #remdesivir do not include any of the compounds described in the WIV patent. Does Gilead actually own any of these WIV compounds?? 3/4
First-in-Woman Safety, Tolerability, and Pharmacokinetics of Orally Administered #GS441524: A Broad-Spectrum Antiviral Treatment for #COVID19. A 🧵1/7 osf.io/am5s8/
Part 1 of the study: 750 mg GS-441524 was orally administered as a solution QD for 7 days. D1-5 were performed in the fasted state. D6-7 in the fed state. There was a slight food effect that seemed to hamper drug absorption. Cmax ~2.4-3 uM. AUC ~26-33 uM. 2/7
No AEs or lab abnormalities were observed in Part 1 of the study. Blood chemistry was normal. 3/7
Fun fact: #remdesivir is almost certainly not the species that reaches #COVID19 patients' lungs! Its nucleoside #GS441524 is. Wrote this piece for @statnews explaining this! @GileadSciences consider aerosolizing GS-441524 prophylaxis. Pls read and RT! 1/x
I've been reading a lot of general audience/science articles on #remdesivir. Many of these articles seem to confuse nucleoSIDES with nucleoTIDES. Here's the difference, feat. important figures. 2/x
#remdesivir is a nucleoTIDE monophosphate analogue. #GS441524 is a nucleoSIDE analogue. 3/x