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Victoria Yan Profile picture
Victoria Yan
@victoriacyanide
Phosphonate chemist by habit, scientist by choice, Molecular Sherlock by chance. #GS441524
Apr 12, 2023 • 13 tweets • 6 min read
NEW OBELDESIVIR (OBV; GS-5245) DATA! $GILD

Ph1 PK/PD from @GileadSciences' @ECCMID poster.

OBV = OBVIOUS! 🙊😂 #GS441524 #GS5245

Key points in thread 🧵 1/13
https://t.co/zOpymoJLicaskgileadmedical.com/conferences/co… First, this was a healthy volunteer PK study. Impt to point this out bc it was strange that 25% of pts in PBO grp had grade 2 AE 🧐.

Also, note the dosing grps. They tested QD & BID regimens. The ph3 dose is 350 mg BID but this wasnt actually tested here...2/13
Apr 11, 2023 • 4 tweets • 1 min read
FINALLY! @GileadSciences CONFIMRS #GS5245 = OBELDESIVIR!!

"Phase I trial, which involved 70 healthy adults, showed that obeldesivir reached sufficient concentrations in the blood and supports taking it without regard to food"

#GS441524 $GILD #COVID_19

reuters.com/business/healt… You heard it here first!!!! (dec 2022!)
#GS5245 #GS441524 #obeldesivir
Jan 30, 2023 • 8 tweets • 5 min read
Since obeldesivir, figuring out the structure of undisclosed cmpds in the clinic has become my new hobby 🤠

So I'll periodically post structures of other cmpds here

I'll start w #VX548, a Nav1.8 inhibitor for treating pain by @VertexPharma $VRTX. Inspired by @cispt2 1/8 VX-548 is currently in ph3 for the tx of acute pain. From trials registry, the earliest trial date is on July 19, 2021. 2/8
Dec 28, 2022 • 16 tweets • 10 min read
When did @GileadSciences decide that #GS441524 hypothesis was valid? Clues in patent history🔍

While Gilead bashed GS-441524 in 2020, they quietly worked on oral prodrugs

Could we have had an oral COVID pill in late '20/early '21? 💊

I think YES 🧵1/16
worldwide.espacenet.com/patent/search?… Patent on oral GS-441524 prodrugs has 1st priority filing on AUGUST 27, 2020. So they did not think the '524 hypothesis was worthless in 2020. 2/16
statnews.com/2020/05/14/gil…
Nov 29, 2021 • 5 tweets • 5 min read
BIG NEWS: deuterated #GS441524 tri-iBu ester (#VV116) is in clinical trials in Uzbekistan for #COVID19. Trials in China 🔜. Developed by the one and only *Wuhan Institute of Virology*. Deuterium was added to bypass @GileadSciences 💊 1/4
@ncats_nih_gov
shine.cn/news/nation/21… Image Official article published in @cell_res in September 2021 by the folk at Wuhan Institute of Virology. Original @biorxivpreprint was published in November 2020. 2/4
nature.com/articles/s4142…
Apr 9, 2021 • 7 tweets • 4 min read
First-in-Woman Safety, Tolerability, and Pharmacokinetics of Orally Administered #GS441524: A Broad-Spectrum Antiviral Treatment for #COVID19. A 🧵1/7 osf.io/am5s8/ Part 1 of the study: 750 mg GS-441524 was orally administered as a solution QD for 7 days. D1-5 were performed in the fasted state. D6-7 in the fed state. There was a slight food effect that seemed to hamper drug absorption. Cmax ~2.4-3 uM. AUC ~26-33 uM. 2/7
May 14, 2020 • 10 tweets • 8 min read
Fun fact: #remdesivir is almost certainly not the species that reaches #COVID19 patients' lungs! Its nucleoside #GS441524 is. Wrote this piece for @statnews explaining this! @GileadSciences consider aerosolizing GS-441524 prophylaxis. Pls read and RT! 1/x

bit.ly/3dIc0Au I've been reading a lot of general audience/science articles on #remdesivir. Many of these articles seem to confuse nucleoSIDES with nucleoTIDES. Here's the difference, feat. important figures. 2/x