Thread by @_ppmv

1. Where do we stand on COVID-19 in Year Four?

SARS-CoV-2 is slowly reverting to its long-term trend of increasing viral load (=severity) after a one-year surprise dip thanks to Omicron.

Most people seem wildly determined to learn by experience. Good luck mates, you'll need it!

https://twitter.com/_ppmv/status/1620726794902196224

2. Viral load thread. 👍

https://twitter.com/_ppmv/status/1615528138418651137

3. It was never easier to be a Good person than today. No need to invent novel ideas like "hygiene" for infants. All you need to do is take and apply what already exists, and was common sense until people grew enamoured with the idea of "Living with SARS".

https://twitter.com/_ppmv/status/1582094314011664384

4. Don't halve human life expectancy.

I don't care about your climate or other policy views on this: if SARS is your way of governing the descent of humanity into a far more primitive, cruel, short-lived, form, then you're not supposed to be in charge.

https://twitter.com/_ppmv/status/1619665799660339203

5. Once again for emphasis: "Don't halve human life expectancy."

Any kindergarten child understands this message; any politician should as well. It could hardly be simpler.

We are far along the way already, ever since Omicron emerged.

https://twitter.com/_ppmv/status/1615834524327514116

6. Simple down-to-earth message for anyone in your lives:

https://twitter.com/RealCheckMarker/status/1620039876585619456

7. Simple high-level message for anyone professionally engaged in politics or analysis. You always have a choice. We can stop the gobal spread of VoC tomorrow if we care. It's a political problem, far more than the overwhelming eng/natsci focus on twitter.

https://twitter.com/_ppmv/status/1618254517518364672

I hope this and related threads cleared some confusion. Be well everyone!

Why not share this, relatively few views for some reason:

https://twitter.com/_ppmv/status/1617127070987071491

Always remember:

https://twitter.com/_ppmv/status/1609230044806762497

Share this with those who think we need to learn to "Live with SARS" - a tragically naive idea if ever I heard one:

https://twitter.com/_ppmv/status/1582094324870758401

Happy third birthday to this prescient tweet.

The public isn't being told Omicron (XBB.1.5+) reset everything:
RAT & PCR tests,
Antibody treatment,
Bivalent vaccine antibodies.
We are back to square zero.
SARS doesn't kill—it disables. Wear a mask.

It's a global policy problem.

8. Today is also the third birthday of the retraction of Pradhan et al 2020, "Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag". Quoted 164 times, its muzzling was a low point for science. ht @armarcus @ivanoransky biorxiv.org/content/10.110…

@armarcus @ivanoransky 9. I hope you all read the current literature. We're pursuing policy - and research funding! - that will almost certainly fail. It's not hard to do better. We probably should. mdpi.com/1422-0067/24/3…

@armarcus @ivanoransky 10. Was Pradhan 2020 right? (hashtag #pradhanwasright)

Technically not, but that's the normal process of science.

The forced retraction from the highest level had a chilling effect on science, putting billions at risk.

Many were & remain complicit.

See frontiersin.org/articles/10.33…

@armarcus @ivanoransky The uncanny similarity in genomic organization, enzymatic and structural proteins explains the shared evolutionary potential of SARS-CoV-2 and HIV-1.

COVID-19 vaccines won't succeed.

Fantini 2023 show what 40 years of HIV science teach us.
ganglioside, lipid raft, #quasispecies

@armarcus @ivanoransky * Zhang 2020, used to 'refute' Pradhan 2020, may be flawed. RatG13 and other genomes were mysteriously 'discovered' after SARS-CoV-2 emerged. An elaborate game of mirrors and limited hangouts for law enforcement. Scientists are too naive & untrained.

Not my circus not my monkeys

@armarcus @ivanoransky 12. Focus: 'This retrovirus and coronavirus share common molecular mechanisms in entry mechanisms, a potent virotoxin activity and induce similar pathological symptoms in GI/brain. SARS-CoV-2 infection can induce an immunosuppression, a hallmark of HIV-1 disease.' We told you all

@armarcus @ivanoransky @T_Brautigan and others been going on about Japan/Israel and HLA haplotypes. My new favorite theory is that he's secretly no time traveler but a modest Nobel Prize laureate. May be less cool, but just as well as long as our warnings are taken seriously. 🙏

https://twitter.com/_ppmv/status/1581584273785892864

Excursion END, sorry if it was a bit much for anyone. I doubt we have the luxury of time in year Four, hence the regular reminder(s).

13. German mask and isolation mandates are ending tomorrow, accelerating the pandemic. Above is no thread of anger; just a simple minimal intro to the basic level of knowledge every student needs to have.

From now on there will be SARS+ students in class.

https://twitter.com/Karl_Lauterbach/status/1620680086616678401