Biotech2k Profile picture
Feb 13 19 tweets 6 min read
🧵You can own the Future of Tomorrow Today.

I have heard many people try to call this crash in biotech the end of the #Biotechnology sector. A sector that has been around for decades. One of the most necessary sectors in the entire market.
1/ Here I am going to lay out for you the opposite case. I have been investing in tech and biotech for 27 years. I have seen so much technology that excites me about the future, and I see it today.
2/ The biggest question I always get in biotech investing is when will we run out of things to discover or great new technologies to invent. I my response is we will never run out until we cure every disease.
3/ We are entering a very exciting new era in biotechnology where we have new tools that could completely redefine the future. People who listen to those naysayers could be missing the best opportunity of their lifetimes.
4/ I actually have more excitement and investment ideas today than I ever had in my 27 years of investing. New technologies like using #AI or #MachineLearning to make new connections in biology or genetics could revolutionize how we approach drug discovery.
5/ #Automation can reduce workloads and simplify redundant processes to bring down costs of drug discovery. We have come to call this space of biotech the #TechBio space. This is just beginning to get started.
6/ Right now everyone is skeptical of this space. I think in 10 years, any company that did not embrace these technologies will fade away into the history books of time. There are going to be new leaders in this space that emerge to become tomorrow's Google or Amazon.
7/ We can find them today for a mere fraction of what they could be tomorrow. Most of these companies are selling near their levels of cash. The discovery of new technology will always get funding by the visionary few.
8/ The next space of excitement is #GeneEditing tools like #CRISPR. These tools are in their infancy and will continue to evolve as bright mind continue to find new ways to use them to do editing safer and easier.
9/ Barriers like delivery will be broken and there will be a revolution in fixing and removing Genetic Diseases from the human race. The companies that succeed here will be worth fortunes.
10/ The power of gene editing has given birth to #SyntheticBiology. This is the ability to take gene editing tools and use it to reprogram microbes to make them beneficial. We can reprogram pathogens to produce fertilizer or scrub carbon from the environment.
11/ The future ability of scientist to rewrite life on earth using gene editing can be exciting and terribly frighting. It is an awesome power and responsibility. There is going to be a need for #Biosecurity to protect use from the ability of bad actors to misuse this technology.
12/ Rewriting life won't just stop with microbes. We can use it to create human cells from stem cells. We have technologies like Induced Pluripotent Stem cells #iPSC that can allow us to reprogram human cells.
13/ We can create cell therapies to fight #cancer already today. This is just getting started as we learn more about cell biology and human biology. I believe someday we will be able to grow entire organs from a single cell donation.
14/ The last area will be the revolution of #Sequencing. This has been a space of rapid evolution. We are still far from the ability to do end to end sequencing on every genome on earth for a very low cost.
15/ Someday, we will get our genome sequenced and we will know everything about ourselves. The risk and the benefits. We will be able to tailor medicine to the individual. Personalized medicine is only just beginning with cancer therapies.
16/ Someday we will know our risk long before it even becomes a disease. We will be focused more on prevention and correction before the disease occurs. Combining sequencing with other therapies like gene editing could allow sickness to be corrected before it happens.
17/ While many have taken to writing article predicting the end of biotechnology, I have taken to the spreading of the Science Of The Future. I think scary sells a lot of articles, but vision will favor the investor.
18/ If you are interested in learning more, I have an entire website set up dedicated to the science and companies pioneering these industries of tomorrow. Feel free to check it out.
biotech2k.com/innovation/inn…

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More from @Biotech2k1

Feb 17
🧵Cell Biology

Here we will look at the structure of a cell.
1/ The human body is made up of organs and each organ has a specific role in the larger organism. We have a heart to circulate blood, lungs to take in oxygen and stomach to digest food.
2/ In the same way the body has organs, the cells have organelles which are small parts of the cells with a specific function. Many if not all these organelles will be found in cells. Image
Read 24 tweets
Feb 15
🧵What is Life?

Here we will look at the biology attributes of what determines life.
1/ Biology is the study of life and living things. Since all living things are made up of atoms, chemistry is the first science that goes into understanding biology. I would recommend everyone learn about chemistry to build a foundation for biology.
2/ The first thing we have to look at in biology is, what is a living thing? How do we classify what is alive and what isn't? We would all agree that a flower or a rabbit is alive while a stone or gold bar is not. Some things are not that easy. Is a virus really alive?
Read 19 tweets
Dec 27, 2022
🧵A look at the phases of clinical trials.

Here we will look at the different steps of clinical trials. The key to remember is trials for non life threatening diseases are different than they are for serious and life threatening diseases.
1/ First will be years of preclinical work. This is all about the chemistry, formulation, toxicology and manufacturing of the drug. They will have to extensive testing and submit all that data to the FDA for the Investigational New Drug (IND) application.
2/ The first studies will be done in human cells. This will be to establish a proof of concept of how the biology works in the cells. Then they will move to animal models. This is often mice and Non Human Primates (NHP).
Read 25 tweets
Dec 26, 2022
🧵The Targeted Protein Degrader Report

This technology harnesses the cells natural ability to tag unwanted proteins for destruction. This tagging process is done by E3 ligases. The tagged proteins are then fed into the Proteasome which acts like a shredder.
1/ Kymera Therapeutics $KYMR

This company was founded in 2015 by its current CEO @NelloMainolfi. He has an active presence on social media and seems to being doing a great job at develop this early stage biotech company.
2/ They are focused on mapping and discovering the over 600 E3 ligases to find those that are tissue specific for targeted therapies. They have multiple drugs in development around Inflammation and Oncology.
Read 29 tweets
Dec 25, 2022
🧵The Kinome Report

A kinase is a protein that acts like a switch. It can be turned on or off. There are over 600 known proteins in the human genome that act as kinases. We still don't know what many of them do.
1/ Blueprint Medicines $BPMC

This company was founded in 2011. Its current CEO is actually new as Jeff Albers has since moved to the Chairman role. Kate Haviland was the COO and should do a great job. Its been around a long time and its a commercial level biotech company now.
2/ They are working mostly on key kinases that target oncology and the cell cycle. These are the proteins that mutate to become oncogenes. They typically occur in growth factor pathways and drive uncontrolled cell growth.
Read 40 tweets

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