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Feb 20 • 5 tweets • 4 min read
#DoxyPEP prevented STIs in gay men, but Jenell Stewart reports this was not the case for cisgender women. May be due to differing drug concentrations in vaginal/cervical vs rectal tissue or low adherence. We’ve seen something similar with TDF/FTC PrEP for women. #CROI2023
Here's my report for @eBARnews on the #doxyPEP study in gay & bi men & trans women presented last year.
ebar.com/story.php?3193…
Jennell Stewart (@drjenellstewart): "Stigma is a major issue regarding sexual health, STIs & HIV. It needs to be addressed if were going to make progress in this area." #DoxyPEP presenters at #CROI2023
Good report from @benryanwriter. (Clearly he focused on this as a first #CROI2023 report while I focused on the Dusseldorf Patient.)

Here’s my report for @aidsmap aidsmap.com/news/feb-2023/…

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More from @LizHighleyman

Liz Highleyman Profile picture
Feb 22
It's been a long day at #CROI2023, but I'll attempt to live-tweet @MichaelPelusoMD's presentation on #longCOVID. Though mainly an #HIV meeting, CROI also includes the hot infectious diseases of the day. (Thanks Dr Peluso for providing advance slides & permission to share.) 1/ Image
@MichaelPelusoMD .@MichaelPelusoMD & colleagues' SCOPE cohort at @UCSF + international collaborators have now studied more than 700 people with #longCOVID 2/ Image
.@MichaelPelusoMD at #CROI2023: #LongCOVID is many things. 3/ Image
Read 23 tweets
Liz Highleyman Profile picture
Feb 21
.@MonicaGandhi9 presents promising results from @ZSFGCare @SF_DPH SPLASH program to treat disadvantaged safety-net population at Ward 86 with long-acting injectable antiretrovirals -- even if not virally suppression at outset. #CROI2023 1/ Image
Among those without viral suppression (ie, outside FDA indication for Cabenuva), 55 out of 57 achieved undetectable VL after starting monthly injectables -- comparable to rates seen in pivotal clinical trials. 2/ Image
.@MonicaGandhi9: We need innovations in #HIV treatment for this population. "If used creatively & used boldly, long-acting ART could really make a dent in the HIV epidemic." #CROI2023 3/
Read 6 tweets
Liz Highleyman Profile picture
Feb 21
Susan Buchbinder (@SF_DPH @BridgeHIV) & Larry Corey (@fredhutch) discuss where we are with #HIV vaccines after Mosaico trial failure. Buchbinder says it's "a very vibrant time" in HIV vaccine research. Corey adds that the science is "terrifically fascinating." #CROI2023 1/ Image
I think his characterization of sophisticated novel HIV vaccine approaches as "a little bit more complicated" & going to "take a little more time" is an underestimate. It's certainly a lot more complicated to explain versus traditional vaccines! 2/
poz.com/article/hiv-va…
But it's good to hear they're optimistic. I've been kind of discouraged about the #HIV vaccine research field since doing this @pozmagazine overview a couple years ago. #CROI2023 3/
poz.com/article/shot-d…
Read 4 tweets
Liz Highleyman Profile picture
Feb 21
.@profchloeorkin presents disturbing data on #monkeypox/#mpox among HIV+ people w/low CD4 counts. High rate of complications & death. Concludes mpox is an opportunistic pathogen & severe necrotizing form is an AIDS-defining condition, @CDCgov & @WHO should include. #CROI2023 1/ ImageImage
Concern about IRIS for people who start antiretrovirals once severe symptoms are underway -- can make worse. But unclear whether ART would be beneficial if started at beginning of mpox symptoms. 2/
The good news is no #HIV+ people with a CD4 count >200 died, nor did anyone who received #mpox vaccine. 3/
Read 9 tweets
Liz Highleyman Profile picture
Dec 31, 2022
Since it's that time of year, here's a selection of some of my favorite articles I wrote in 2022.
My main focus is #HIV. Here, for @pozmagazine, a look at advances in antiretroviral treatment & prospects for a functional cure. 1/
poz.com/article/long-w…
For @aidsmap, a report from #AIDS2022 about a 5th person cured of #HIV after a stem cell transplant. (The 4th such case was reported earlier in the year at #CROI2022/#CROI22). 2/

aidsmap.com/news/aug-2022/…
I did a couple articles on #HIV vaccines, which remain elusive. But mRNA technology is advancing that effort & also showing promise for cancer vaccines. 3/

cancerhealth.com/article/mrna-r…
Read 10 tweets
Liz Highleyman Profile picture
Dec 30, 2022
This psychologizing of people with different risk tolerance is tedious. Mask proponents can't grasp that we've seen evidence over 3 years that masking doesn't appear to affect case trajectories much at the community level & decided marginal benefits aren't worth the drawbacks. 1/
.@ianmSC can be a gadfly, but he's posted many graphs like this showing that cities & countries with mask mandates or strong masking culture have case trajectories similar to those of places that don't. 2/

If masks had a substantial protective effect at the community level, it should be clearly apparent by now, like the substantial effect of vaccines on COVID hospitalization & deaths. 3/
Read 7 tweets

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