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Feb 21 • 9 tweets • 7 min read
.@profchloeorkin presents disturbing data on #monkeypox/#mpox among HIV+ people w/low CD4 counts. High rate of complications & death. Concludes mpox is an opportunistic pathogen & severe necrotizing form is an AIDS-defining condition, @CDCgov & @WHO should include. #CROI2023 1/
Concern about IRIS for people who start antiretrovirals once severe symptoms are underway -- can make worse. But unclear whether ART would be beneficial if started at beginning of mpox symptoms. 2/
The good news is no #HIV+ people with a CD4 count >200 died, nor did anyone who received #mpox vaccine. 3/
I hope I didn't flub the embargo. Dr Orkin provided slides beforehand & accompanying article in The Lancet is now off embargo. 4/
(Warning: includes images of severe #mpox)
thelancet.com/journals/lance…
.@kakape has done a good summary of the global #mpox case series for @ScienceMagazine.

.@benryanwriter has done the same for @NBCNews. I'll be writing this up for @aidsmap & @pozmagazine tonight.

A poster at #CROI2023 (abstract 912) saw severe #mpox among people with HIV in the U.S.

As I previously reported, a @CDCgov case series also saw dire #mpox outcomes among HIV+ with advanced immunosuppression.

poz.com/article/monkey…

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More from @LizHighleyman

Liz Highleyman Profile picture
Feb 22
And now at #CROI2023, a special session on #monkeypox/#mpox.
John Brooks of @CDCgov: Mpox decline has not been even in all places -- we need to keep our eye on places where it hasn’t declined as much & need to stay vigilant for reemergence. Image
I'm not going to try to live-tweet this one & didn't request advance permission to share slides.
John Brooks (@CDCgov): Let’s get people vaccinated against #monkeypox/#mpox now, before spring & summer. Summer means Pride, Pride means a lot of fun, a lot of fun means a lot of sex. #CROI2023 Image
Read 8 tweets
Liz Highleyman Profile picture
Feb 22
It's been a long day at #CROI2023, but I'll attempt to live-tweet @MichaelPelusoMD's presentation on #longCOVID. Though mainly an #HIV meeting, CROI also includes the hot infectious diseases of the day. (Thanks Dr Peluso for providing advance slides & permission to share.) 1/ Image
@MichaelPelusoMD .@MichaelPelusoMD & colleagues' SCOPE cohort at @UCSF + international collaborators have now studied more than 700 people with #longCOVID 2/ Image
.@MichaelPelusoMD at #CROI2023: #LongCOVID is many things. 3/ Image
Read 24 tweets
Liz Highleyman Profile picture
Feb 21
.@MonicaGandhi9 presents promising results from @ZSFGCare @SF_DPH SPLASH program to treat disadvantaged safety-net population at Ward 86 with long-acting injectable antiretrovirals -- even if not virally suppression at outset. #CROI2023 1/ Image
Among those without viral suppression (ie, outside FDA indication for Cabenuva), 55 out of 57 achieved undetectable VL after starting monthly injectables -- comparable to rates seen in pivotal clinical trials. 2/ Image
.@MonicaGandhi9: We need innovations in #HIV treatment for this population. "If used creatively & used boldly, long-acting ART could really make a dent in the HIV epidemic." #CROI2023 3/
Read 6 tweets
Liz Highleyman Profile picture
Feb 21
Susan Buchbinder (@SF_DPH @BridgeHIV) & Larry Corey (@fredhutch) discuss where we are with #HIV vaccines after Mosaico trial failure. Buchbinder says it's "a very vibrant time" in HIV vaccine research. Corey adds that the science is "terrifically fascinating." #CROI2023 1/ Image
I think his characterization of sophisticated novel HIV vaccine approaches as "a little bit more complicated" & going to "take a little more time" is an underestimate. It's certainly a lot more complicated to explain versus traditional vaccines! 2/
poz.com/article/hiv-va…
But it's good to hear they're optimistic. I've been kind of discouraged about the #HIV vaccine research field since doing this @pozmagazine overview a couple years ago. #CROI2023 3/
poz.com/article/shot-d…
Read 4 tweets
Liz Highleyman Profile picture
Feb 20
#DoxyPEP prevented STIs in gay men, but Jenell Stewart reports this was not the case for cisgender women. May be due to differing drug concentrations in vaginal/cervical vs rectal tissue or low adherence. We’ve seen something similar with TDF/FTC PrEP for women. #CROI2023
Here's my report for @eBARnews on the #doxyPEP study in gay & bi men & trans women presented last year.
ebar.com/story.php?3193…
Jennell Stewart (@drjenellstewart): "Stigma is a major issue regarding sexual health, STIs & HIV. It needs to be addressed if were going to make progress in this area." #DoxyPEP presenters at #CROI2023
Read 5 tweets
Liz Highleyman Profile picture
Dec 31, 2022
Since it's that time of year, here's a selection of some of my favorite articles I wrote in 2022.
My main focus is #HIV. Here, for @pozmagazine, a look at advances in antiretroviral treatment & prospects for a functional cure. 1/
poz.com/article/long-w…
For @aidsmap, a report from #AIDS2022 about a 5th person cured of #HIV after a stem cell transplant. (The 4th such case was reported earlier in the year at #CROI2022/#CROI22). 2/

aidsmap.com/news/aug-2022/…
I did a couple articles on #HIV vaccines, which remain elusive. But mRNA technology is advancing that effort & also showing promise for cancer vaccines. 3/

cancerhealth.com/article/mrna-r…
Read 10 tweets

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