Does #metformin reduce hospitalization or not? In a double-blind placebo controlled trial, 28-day data:
NIH guidelines cite the 14-day mITT data where there was not a statistical reduction.
The 14-day and 28-day ITT data also had a statistical reduction in hospitalization.
NIH guidelines cite the 14-day mITT data where there was not a statistical reduction.
The 14-day and 28-day ITT data also had a statistical reduction in hospitalization.
These numerical complete case data were published in NEJM.
"Through day 28, hospitalization or death occurred in 8 of 596 patients (1.3%) receiving metformin and in 19 of 601 controls (3.2%)"
(2.9% & 1.2% above are by Kaplan-Meier methodology).
nejm.org/doi/full/10.10…
"Through day 28, hospitalization or death occurred in 8 of 596 patients (1.3%) receiving metformin and in 19 of 601 controls (3.2%)"
(2.9% & 1.2% above are by Kaplan-Meier methodology).
nejm.org/doi/full/10.10…
While the authors were not allowed to highlight these data or put a p-value in, apparently there are a lot of poeple who can't run a chi-square or fisher's exact test -- as I keep hearing that metformin didn't reduce hospitalization in the COVID-Out trial.
As the cost of metformin is $1, there is no big pharma pushing this med. Most impressive is the 42% reduction in #LongCovid diagnoses shown in a randomized, double-blind trial.
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