Thread by @nick_krontiris

This one in twins finds that active individuals are more likely to have an intramyocellular lipid phenotype resembling that of athletes.

- Findings also suggested that efficient BCAA catabolism together with BCAA availability are crucial for this intramyocellular lipid phenotype to occur.

To put this into perspective, metabolic syndrome is more than often accompanied by impaired BCAA catabolism.

- "Our results suggest that the athlete paradox phenotype may not be genetically determined and might be reached via life-long LTPA (leisure-time physical activity)."

Effects of Long-Term Physical Activity and BCAA Availability on the Subcellular Associations between Intramyocellular Lipids, Perilipins and PGC-1α (open access)

doi.org/10.3390/ijms24…

#exercise #muscle #lift #cardio #hiit #MetabolicSyndrome #InsulinResistance