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Mar 23 • 6 tweets • 3 min read
In this one in adults with obesity without diabetes who initially lost at least 5% of body weight, only the combination of an aerobic exercise program and a GLP-1 receptor agonist improved postprandial glucose & glucagon responses and beta cell function compared with placebo. Image
- The aim of this study was to investigate glucose tolerance, glucagon response, and beta cell function during a 1-year maintenance period with either exercise, the glucagon-like peptide-1 receptor agonist liraglutide, or the combination after diet-induced weight loss.
- In this randomized placebo-controlled trial, adults with obesity (BMI: 32–43 kg/m2) without diabetes underwent an 8-week low-calorie diet (800 kcal/d) and were randomized to 52 weeks of aerobic exercise, liraglutide 3.0 mg/d, exercise and liraglutide combined, or placebo.
- One year after diet-induced weight loss, the combination of exercise and the glucagon-like peptide-1 receptor agonist liraglutide improved postprandial glucose & glucagon responses and beta cell function compared with placebo.
- On the other hand, liraglutide alone improved postprandial glucose response but not glucagon response and beta cell function, whereas exercise alone after weight loss was not associated with improvements on postprandial glucose & glucagon response and beta cell function.
Weight loss maintenance with exercise and liraglutide improves glucose tolerance, glucagon response, and beta cell function (open access)

doi.org/10.1002/oby.23…

#weightloss #MetabolicSyndrome #InsulinResistance #Obesity #Diabetes

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Nick Krontiris Profile picture
Mar 25
In this one, cardiorespiratory fitness was found to be associated with a lower risk of incident Alzheimer’s disease and related dementias, with the association being graded in nature so that a higher level of fitness was associated with a lower level of risk. Image
- The study examined the association between cardiorespiratory fitness expressed in METs and incident Alzheimer’s disease and related dementias in a large national cohort of US veterans with a mean age of 60.5 years during up to 20 years of follow-up.
- The study’s findings demonstrated an inverse, graded association between cardiorespiratory fitness and the incidence of Alzheimer’s disease and related dementias regardless of sex or race.
Read 4 tweets
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Mar 25
This systematic review and meta-analysis of prospective cohort studies suggests that the consumption of alcohol is positively related to the risk of total, osteoporotic and hip fractures. Image
- The meta-analysis based on 42 prospective cohort articles indicated that high alcohol consumption is likely to increase the risk of total, osteoporotic and hip fractures, but not wrist and vertebral fractures.
- A linear positive relationship between alcohol consumption and risk of total fractures was found.
Read 6 tweets
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Mar 25
Using data from the Kuopio Ischemic Heart Disease study, this one suggests that high cardiorespiratory fitness levels may attenuate the increased risk of cardiovascular disease mortality in individuals with elevated systolic blood pressure in men aged 42–61 years. Image
- The Kuopio Ischemic Heart Disease study is an ongoing population-based prospective cohort study that was designed to investigate risk factors for atherosclerotic cardiovascular disease.
- The study recruited a general population sample of 2682 men aged 42–61 years who were residents in eastern Finland.
Read 8 tweets
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Mar 25
The findings of this one suggest that frailty is a common finding in survivors of COVID-19 requiring hospitalisation, as both physical frailty and pre-frailty were found to be common at 1 year following discharge, together remaining present in two-thirds of its participants. Image
- "While some recovery is seen between 5 months and 1 year we identified that those least likely to recover were older, more likely to be female, have been treated in ICU, have multiple co-morbidities and live in an area with higher levels of deprivation."
- "Those who remain frail or pre-frail at 1 year are more likely to report that they have not recovered from their acute illness, while those who are frail suffered a greater and more persistent fall in their HRQoL from prior to hospitalisation for COVID-19."
Read 6 tweets
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Mar 25
In this one, low muscle muscle mass, as measured by the skeletal muscle mass index, combined with further muscle losses within a period of 2 years was associated with diabetes occurrence in Chinese individuals with a mean age of 57.7 years. Image
- Baseline skeletal muscle mass index was associated with future diabetes incidence, but only in adults with impaired glucose tolerance.
- Higher muscle loss rates were associated with an over 2-fold risk of developing diabetes after adjusting for baseline skeletal muscle mass index and other risk factors in adults with normal glucose tolerance and impaired glucose regulation.
Read 6 tweets
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Mar 25
This systematic review and meta-analysis finds that blood flow restriction (BFR) combined with low load resistance training appears to be equally effective to high-load resistance training for improving muscle strength in upper body muscles.
- Analysis suggested that blood flow restriction combined with low load resistance may result in better strength and size adaptations compared to similar exercise without BFR in muscles proximal to the applied cuff, with low quality of evidence and mixed findings.
- Low and very low certainty evidence suggested increases in bench press 1RM (2–4 weeks) and in shoulder flexion MVIC (6–8 weeks) in favor of the low-load-with- compared to the low-load-without BFR group.
Read 12 tweets

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