"the IC50 of quercetin, isoquercetin, rutin, and quercetin-3-glucuronide, were >100, 7.1, 6.1, and 5.9 μM, respectively, indicating that these C3 modification in the quercetin derivatives enhanced the anti-PDI activity."
"At 1000 mg daily, isoquercetin inhibited plasma PDI activity and significantly reduced plasma D-dimer levels along with soluble P selectin and platelet-dependent thrombin generation."
"quercetin was found to demonstrate weaker anticoagulant properties than isoquercetin, probably because of the differences in their chemical structure."
"We further show that ERp44 depletion exacerbates ER stress in DN in db/db mice, and that attenuating ER stress with the chemical chaperone TUDCA remarkably diminishes the aggravated DN features caused by ERp44 depletion."
"SunActive IsoQ is a new and novel isoquercitrin precursor to quercetin. This solubilized form of quercetin precursor is 25 times more bioavailable than quercetin itself."
"Susceptibility to childhood herpes simplex encephalitis (HSE) caused by HSV-1 infection has been attributed to inborn errors of immunity affecting production or sensing of type I interferon."
"Using whole-exome sequencing, Liu et al. identified a patient with HSE bearing compound heterozygous variants in RIPK3, a key cytoplasmic regulator of cell death."
"We previously reported that monoclonal antibodies to protein-disulfide isomerase (PDI) and other membrane-impermeant PDI inhibitors prevented HIV-1 infection."
"Arguably, the most successful zoonotic parasite is Toxoplasma gondii, with the highly proliferative form (tachyzoites) capable of infecting virtually all warm-blooded animals and replicating in most nucleated cell types."
"ATF6β-deficient mice exhibit a high susceptibility to infection by the parasite, indicating that ATF6β has a key role in resistance against T. gondii infection."
"The mechanism of neuropathogenesis in brain toxoplasmosis has been investigated in murine neural stem cells isolated from mouse embryos and in C17.2 cells."
"Cysteamine works by accumulating in the lysosomes and stops the oxidation of LDL cholesterol. It is already known to be safe in humans where it’s used to treat a rare lysosomal disease called cystinosis."
Cysteamine Decreases Low‐Density Lipoprotein Oxidation, Causes Regression of Atherosclerosis, and Improves Liver and Muscle Function in Low‐Density Lipoprotein Receptor–Deficient Mice
"In #COVID19, the infection and immune hyperactivation causes accumulation of inflammatory immune cells, blood clots, and protein aggregates in lung fluid, increased lung alveolar wall thickness, and upregulation of serum cytokine levels."