"On the cell surface, PDI is imperative for platelet aggregation and transnitrosation, which are related to thrombosis and control of vascular tone by nitric oxide, respectively."
"In conclusion, EMP-PDI promotes early platelet activation through glycoprotein (GP) IIb/IIIa receptors present on platelet surface in the diabetic state."
"Several in vivo thrombosis models have demonstrated that vascular PDI secreted by platelets and endothelial cells is essential for normal thrombus formation."
"Susceptibility to childhood herpes simplex encephalitis (HSE) caused by HSV-1 infection has been attributed to inborn errors of immunity affecting production or sensing of type I interferon."
"Using whole-exome sequencing, Liu et al. identified a patient with HSE bearing compound heterozygous variants in RIPK3, a key cytoplasmic regulator of cell death."
"We previously reported that monoclonal antibodies to protein-disulfide isomerase (PDI) and other membrane-impermeant PDI inhibitors prevented HIV-1 infection."
"Arguably, the most successful zoonotic parasite is Toxoplasma gondii, with the highly proliferative form (tachyzoites) capable of infecting virtually all warm-blooded animals and replicating in most nucleated cell types."
"ATF6β-deficient mice exhibit a high susceptibility to infection by the parasite, indicating that ATF6β has a key role in resistance against T. gondii infection."
"The mechanism of neuropathogenesis in brain toxoplasmosis has been investigated in murine neural stem cells isolated from mouse embryos and in C17.2 cells."
"Cysteamine works by accumulating in the lysosomes and stops the oxidation of LDL cholesterol. It is already known to be safe in humans where it’s used to treat a rare lysosomal disease called cystinosis."
Cysteamine Decreases Low‐Density Lipoprotein Oxidation, Causes Regression of Atherosclerosis, and Improves Liver and Muscle Function in Low‐Density Lipoprotein Receptor–Deficient Mice
"In #COVID19, the infection and immune hyperactivation causes accumulation of inflammatory immune cells, blood clots, and protein aggregates in lung fluid, increased lung alveolar wall thickness, and upregulation of serum cytokine levels."