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Rene Sugar Profile picture
@renesugar
May 6 • 10 tweets • 3 min read Twitter logo Read on Twitter
Protein disulfide isomerase (PDI) inhibition #LongCovid #MECFS #POTS
- PDI

Ero1p oxidizes protein disulfide isomerase in a pathway for disulfide bond formation in the endoplasmic reticulum

"Loss-of-function experiments indicate that PDI supports angiotensin II-mediated ROS generation and Akt phosphorylation."

"On the cell surface, PDI is imperative for platelet aggregation and transnitrosation, which are related to thrombosis and control of vascular tone by nitric oxide, respectively."

"In conclusion, EMP-PDI promotes early platelet activation through glycoprotein (GP) IIb/IIIa receptors present on platelet surface in the diabetic state."

"Several in vivo thrombosis models have demonstrated that vascular PDI secreted by platelets and endothelial cells is essential for normal thrombus formation."

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

- Quercetin, Isoquercitrin, Isoquercetin, Rutin

- Nicotine

- Cysteamine

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More from @renesugar

Rene Sugar Profile picture
May 7
Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiency

science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…

"Susceptibility to childhood herpes simplex encephalitis (HSE) caused by HSV-1 infection has been attributed to inborn errors of immunity affecting production or sensing of type I interferon."
science.org/doi/10.1126/sc…

"Using whole-exome sequencing, Liu et al. identified a patient with HSE bearing compound heterozygous variants in RIPK3, a key cytoplasmic regulator of cell death."
Read 6 tweets
Rene Sugar Profile picture
May 7
Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry

pubmed.ncbi.nlm.nih.gov/12218051/
jbc.org/article/S0021-…

"We previously reported that monoclonal antibodies to protein-disulfide isomerase (PDI) and other membrane-impermeant PDI inhibitors prevented HIV-1 infection."
jbc.org/article/S0021-…

"PDI is present at the surface of HIV-1 target cells and reduces disulfide bonds in a model peptide attached to the cell membrane."
Read 5 tweets
Rene Sugar Profile picture
May 7
Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets

journals.plos.org/plospathogens/…
journals.plos.org/plospathogens/…

"Arguably, the most successful zoonotic parasite is Toxoplasma gondii, with the highly proliferative form (tachyzoites) capable of infecting virtually all warm-blooded animals and replicating in most nucleated cell types."
journals.plos.org/plospathogens/…

"Upon encountering immune pressure from the intermediate host, the tachyzoites are rapidly eradicated,"
Read 4 tweets
Rene Sugar Profile picture
May 7
Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites

future-science.com/doi/10.4155/fs… Image
future-science.com/doi/10.4155/fs…

"ATF6β-deficient mice exhibit a high susceptibility to infection by the parasite, indicating that ATF6β has a key role in resistance against T. gondii infection."
future-science.com/doi/10.4155/fs…

"The mechanism of neuropathogenesis in brain toxoplasmosis has been investigated in murine neural stem cells isolated from mouse embryos and in C17.2 cells."
Read 11 tweets
Rene Sugar Profile picture
May 7
Antioxidant drug reverses process responsible for heart attacks and strokes

reading.ac.uk/news/2021/rese…
reading.ac.uk/news/2021/rese…

"Cysteamine works by accumulating in the lysosomes and stops the oxidation of LDL cholesterol. It is already known to be safe in humans where it’s used to treat a rare lysosomal disease called cystinosis."
Cysteamine Decreases Low‐Density Lipoprotein Oxidation, Causes Regression of Atherosclerosis, and Improves Liver and Muscle Function in Low‐Density Lipoprotein Receptor–Deficient Mice

pubmed.ncbi.nlm.nih.gov/34493066/
Read 5 tweets
Rene Sugar Profile picture
May 7
Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice

pubmed.ncbi.nlm.nih.gov/33481950/
ncbi.nlm.nih.gov/pmc/articles/P…

#SARSCoV2 is a single stranded RNA (ssRNA) virus and contains GU-rich sequences distributed abundantly in the genome."
ncbi.nlm.nih.gov/pmc/articles/P…

"In #COVID19, the infection and immune hyperactivation causes accumulation of inflammatory immune cells, blood clots, and protein aggregates in lung fluid, increased lung alveolar wall thickness, and upregulation of serum cytokine levels."
Read 12 tweets

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