Thread by @nick_krontiris

In this one, ketone ester supplementation was associated with increases in circulating dopamine concentration, and improvements in mental alertness and post-exercise muscular inflammation in ultra-endurance exercise.

- This study explored the potential of ketone ester intake to elevate systemic dopamine concentrations and psychocognitive functioning in an ultra endurance running event.

- As a secondary aim the study also looked at the effect of exogenous ketosis on muscle repair and recovery of functional capacity following the event.

- Eighteen recreational runners participated in a full 100km trail run (n=8), or ran to premature exhaustion (80km: n=6; 60km: n=4).

- Before (25g), during (25g/h), and after (5*25g in 24hours) the trail run they received ketone ester (R)-3- hydroxybutyl (R)-3-hydroxybutyrate supplements or a non-caloric placebo.

- The trail run impaired psychocognitive functioning, but this decrease was fully negated by the ketone ester supplement.

- Ketone ester supplementation was also associated with substantially increased systemic dopamine concentrations.

- Finally, ketone ester intake appeared to inhibit post-exercise skeletal muscle macrophage infiltration, counteracting the increase in AMPK phosphorylation after exercise, indicating improved muscular energy status.

Caveats:

- Due to the caloric content of the drinks, energy intake was ~30% higher in the ketone ester group.

- Ketone ester supplementation did not appear to affect performance (although that was not the point).

Exogenous ketosis increases circulating dopamine concentration and maintains mental alertness in ultra-endurance exercise

doi.org/10.1152/japplp…

#supplements #supplement #exercise #Workout #TrainHard #GymLife #GymTime #muscle #strength #lift #GetStrong #cardio #hiit