I want you to know that Alzheimer's disease-alleviating, neuroprotective effects of vitamin D have been replicated in recent clinical trials. (1/7) #AD#Alzheimers#VitaminD
In a 12-month randomized, double-blind, placebo-controlled trial, these researchers showed that compared to the AD group w/placebo the AD group w/vitamin D supplement (800 IU/day) had a significant reduction in plasma Aβ42 and related biomarkers. (2/7) #RCT#science#research
Plasma Aβ42 is a biomarker that is often used to diagnose Alzheimer's disease and track progression. It's a protein that accumulates in the brain and leads to the formation of amyloid plaques that can damage brain cells and disrupt cognitive function. (3/7)
This group also found improved cognitive function that was tested through a standardized neuropsychological assessments, Wechsler Adult Intelligence Scale-Revised (WAIS-RC) and Mini-Mental State Examination (MMSE). (4/7)
Luckily, if you (or your loved one) are having #cognitive symptoms, you can learn how to optimize your D levels, and several other important nutrients. You can absolutely learn how. I teach people all the time in my online program! (6/7)
It's important that you know that you don't have to wait for a neurologist or any other doctor to finally get an adequate education in nutrition before you can start to feel better. 💜 (7/7)
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Amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disorder that affects nerve cells in the brain and the spinal cord. (1/24)
In people with ALS, these motor neurons die, resulting in the brain's inability to initiate and control muscle movement. (2/24)
As the disease progresses, the muscles gradually weaken, twitch (fasciculate), and waste away (atrophy), and the brain loses the ability to control voluntary movement. (3/24)
If you want to explore the role of magnesium in Alzheimer's disease you will want to perhaps read this thread. And maybe we can extrapolate the effects of magnesium to how it may help other neurodegenerative disorders. 🧵 (1/27)
Magnesium (Mg) is a vital mineral that plays a crucial role in several bodily functions. This mineral helps stabilize proteins, nucleic acids, and lipid membranes, which are important for cell functions. (2/27)
It is a necessary cofactor to make enzymes you need to unlock energy from glucose. It's depleted from the soil so even on a healthy diet you can be you are likely getting insufficient amounts. (3/27)
I want you to understand that the ketone body BHB, produced on a ketogenic diet, is a powerful molecular signaling body. So settle in for a ridiculously long thread. 🧵 (1/27)
We will approach this by looking at an in-vitro study where they looked at the effects of D-BHB. D-beta-hydroxybutyrate is a ketone body that can be produced in the liver during periods of fasting or when following a ketogenic diet. (2/27)
But first, what's the difference between BHB and d-BHB? I will tell you. BHB, or beta-hydroxybutyrate, is a ketone body that is produced by the liver during periods of low carbohydrate intake or fasting. (3/27)
Have you ever heard of glutamate excitotoxicity? No? Well, settle in for a thread. You're going to need to know about this fascinating (and slightly scary) topic that's essential to understanding brain health. 🧵 (1/30)
Glutamate is an excitatory neurotransmitter. You need some constantly being released and taken up by neurons to keep the brain functioning. It is critical to properly function several brain pathways essential for mood and cognitive function. (2/30)
In the prefrontal cortex, glutamate signaling is necessary for executive functions like decision-making, working memory, and attention. When glutamate signaling is functioning properly, it's a very good thing! (3/30)
Some of you are beginning to understand that to have a healthy brain that allows a good mood and rockin' cognitive function, you need to focus on mitochondrial function. Am I right? 🧵 (1/25)
Some pathways maintaining mitochondrial health include mitochondrial biogenesis, mitochondrial dynamics (fusion and fission process shaping mitochondrial morphology), and mitophagy—the process in charge of removing mitochondria through autophagy. (2/25)
Let's discuss the pathways that maintain mitochondrial health and then look at how ketogenic diets might influence those pathways to help you feel better. Shall we begin? (3/25)
The disruption of monoamine neurotransmission is a crucial factor in mental disorders such as depression, schizophrenia, ADHD, and Autism Spectrum Disorder. (1/9)
Monoamine neurotransmission involves the release, reception, & regulation of monoamine neurotransmitters like serotonin, dopamine & norepinephrine in the nervous system. They play key roles in mood, cognition, sleep, appetite, and reward. (2/9)
Many medications target monoamine neurotransmission (e.g., SSRIs) in an attempt to treat these disorders. We all know the success rates in this approach are less than stellar and nobody likes side effects. (3/9)