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Harriet Carroll: Recognise vax-induced long COVID Profile picture
@angryhacademic
Jun 1 • 5 tweets • 4 min read Twitter logo Read on Twitter
the autonomic nervous system has a branch that does not use acetylcholine or noradrenaline as transmitters. instead it uses other things, like nitric oxide, ATP, serotonin, neuropeptide-Y, etc
link.springer.com/content/pdf/10…

some thoughts RE #MECFS #LongCovid #teamclots #dysautonomia 🧵
Nitric oxide gets released (depleted?) in ischaemia reperfusion injuries
jnnp.bmj.com/content/67/1/1

Dysmetabolism is commonly reported in #MECFS
ncbi.nlm.nih.gov/pmc/articles/P…

(Circulating) Serotonin may get depleted with platelet activation
portlandpress.com/biochemj/artic…
Appetite gets dysregulated in #LongCovid and ME, often (not always) causing lower appetite. ME may be associated with higher neuropeptide Y
pubmed.ncbi.nlm.nih.gov/21190576/
Alongside potential choline depletion in some patients:


And adrenergic problems in others (hyperadrenergic #POTS)

It seems if all these ANS neurotransmitters are getting depleted or used for other things, then ANS dysfunction is inevitable?
I'm not really sure what my thinking is here other than lots of things having links. Clarity welcome...

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More from @angryhacademic

Harriet Carroll: Recognise vax-induced long COVID Profile picture
Jun 1
I had an appointment with my best dr the other day and he had a student dr with him.

Whilst the appointment wasnt about my clotting, he asked me to explain how atypically i present with pulmonary emboli and how treatment affects me beyond breathlessness

#medtw
Some notes:
1. My dr knew id be ok with this and im beyond happy he did it

2. My diagnosis is pulmonary emboli but i present exactly how youd expect with #postvac #longcovid with anticoagulants stopping me relapsing
The point was that no one expected me to have pulmonary emboli. I had worsening breathlessness + positive d dimer, but didnt reliably desaturate, no pulmonary hypertension, no DVT signs, etc. Took 14 months to diagnose
Read 5 tweets
Harriet Carroll: Recognise vax-induced long COVID Profile picture
May 31
OHHHH the irony. Not even a week since our paper on persuasive communication devices gets published and a paper has cited a paper of mine using device 4:

#AcademicTwitter 4. Misleading use of refere...
Paper:
ncbi.nlm.nih.gov/pmc/articles/P…
"Osteopontin plays a critical role in the formation of stones & is the leading organic component of urinary calcium kidney stones"

Citation:
pubmed.ncbi.nlm.nih.gov/31676259/ (study about hydration & appetite - we didnt even mention kidneys or osteopontin)
another one
Paper:
sciencedirect.com/science/articl…
"The generation of fresh water can be accomplished in various ways, including fog harvesting, multi-stage flash distillation, reverse osmosis seawater desalination,& so on"
Citation: sciencedirect.com/science/articl… (water intake & diabetes risk)
Read 4 tweets
Harriet Carroll: Recognise vax-induced long COVID Profile picture
May 31
Latest #SIRENStudy paper:
Effectiveness of BNT162b2 mRNA vaccine third doses and previous infection in protecting against SARS-CoV-2 infections during the Delta and Omicron variant waves; the UK SIREN cohort study September 2021 to February 2022
medrxiv.org/content/10.110…
During Delta period:
278 primary infections (4/10,000 person-days follow-up)
85 reinfections (0.8/10,000)

During Omicron period:
2,467 primary infections (43/10,000)
881 reinfections (33/10,000)
Relative vaccine effectiveness 0-2 months post-3rd (Pfizer) vaccine in SARS2 naïve cohort during Delta: 63 (95 % CI 40, 77) %

During Omicron:
35 (95 % CI 21, 47) %
Read 6 tweets
Harriet Carroll: Recognise vax-induced long COVID Profile picture
May 30
Thanks to a very kind collaborator, i have some copeptin (marker of AVP) data, compared to my pre-vaccine measures👇🏻👇🏻👇🏻

Whilst not all samples were taken in ideal conditions, it is clear something funky is (or was) going on with my AVP. some thoughts🧵
#postvac #LongCovid #POTS Graph showing serum copepti...
First a bit of background about copeptin (AVP)

AVP is part of the HPA ("stress") axis. briefly, high AVP = high ACTH = high cortisol

AVP also regulates hydration: low fluid/high salt = high AVP = kidney reabsorption of water = pee less = stay hydrated
1. What i find MOST interesting is that under the most controlled conditions (9am, no fluid), my copeptin was much lower than pre-vaccine on the same day my cortisol came back much lower than pre-vaccine
Read 27 tweets
Harriet Carroll: Recognise vax-induced long COVID Profile picture
May 18
Latest paper from Dr Robin Kerr & me:
#LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis
researchsquare.com/article/rs-293…
Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵
#TeamClots a U-shaped blood vessel. at...
We start by discussing the highly thrombotic nature of acute COVID & how this pathology doesnt cease in those with long COVID. in other words, long COVID is a continuation of the pathology accompanying acute COVID. Importantly, we cant rehabilitate until the pathology is treated
we highlight the role of microclots in capillary occlusion, that coagulopathic outcomes occur after acute covid (e.g. ↑ stroke risk), that there is platelet hyperactivation and endotheliitis, and all this leads to impaired oxygen extraction (and more)
Read 17 tweets
Harriet Carroll: Recognise vax-induced long COVID Profile picture
May 18
Latest venture: Choline

THREAD: Mishmash of ideas and some inferences 🧵

#postvac #longcovid
1. Last year we found:
👉🏻severe B12 deficiency
✅low MMA after B12 replacement...
❌...but still elevated homocysteine
❔low-normal folate
❌no MTHFR gene variant
✅...but correction of homocysteine after folic acid supplementation

this caused confusion because there is no obvious reason why i need so much folic acid to keep my homocysteine down

turns out, choline deficiency can elevate homocysteine
ncbi.nlm.nih.gov/pmc/articles/P…

and B12 deficiency might increase choline needs leading to depletion Folate, Vitamin B12, and Me...
Read 21 tweets

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