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David A. Cohen Profile picture
David A. Cohen
@DavidACohen_MD
Endocrinologist, hospitalist, educator. Vice Chair, Education @RWJMS. Honing my skills as father, husband, friend, & bad joke-teller. He/him/his. #EndoTwitter
Shanil Keshwani Profile picture 1 subscribed
Mar 3, 2019 • 15 tweets • 11 min read
1/15

For my first #Tweetorial, I will start with a question:

Which of the following medications from the SGLT2 inhibitor class have been shown to decrease cardiovascular morbidity and mortality?

#Diabetes #EndoTwitter #MedEd #MedTwitter #DM2 #T2D #CardioTwitter 2/15

Sodium glucose transporters (SGLT) in proximal tubules mediate glucose reabsorption.

How?
Na/K ATPase moves Na out & K into the cell ➡️gradient for Na to flow intracellular

SGLT uses this potential to move glucose against its gradient from the tubular fluid into the cell.