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History of Diabetes. A thread.

1550 B.C: “Too Great Emptying Of The Urine”

First ever recorded mention of diabetes in Ebers Papyrus, written around 1550 BC, excavated in 1862 AD from an ancient grave in Egypt.

#EndoTwitter #Diabetes #MemoryLane
@JoyYWu @StanfordMed @MedscapeEndo @TheEndoSociety @Endocrine_News Around the same time, Indian physicians seemed to stumble upon a mysterious illness with "Honey Urine" which attracted ants and flies. They started to use the ants to diagnose the illness.

#EndoTwitter #Diabetes #MemoryLane
@JoyYWu @StanfordMed @MedscapeEndo @TheEndoSociety @Endocrine_News 230 B.C

Egyptian healer/historian, writer of 'On the Names of the Parts of the Human Body', Apollonius of Memphis, names the illness "Diabetes" (dia – through, betes – to go].

#EndoTwitter #Diabetes #MemoryLane #MedTwitter
Read 13 tweets
💥Current American Diabetes Association guidelines recommend Metformin as the 1st line therapy for all T2DM patients👇🏽
⚡️But should Metformin be the 1st line therapy in T2DM patients with cardiovascular disease?
1/
#Metformin
#endotwitter
#cardiotwitter
💥Let’s review the following about
Metformin:

⚡️Mechanism of action
⚡️Safety profile
⚡️Cardiovascular benefits
2/
💥How does Metformin work?

⚡️It inhibits gluconeogenesis in the liver by mitochondrial inhibition & by ⬆️ activation of AMP-kinase👇🏽
⚡️It ⬆️ insulin sensitivity
⚡️It may have additional pleiotropic
effects👇🏽
3/
Read 12 tweets
1/15

For my first #Tweetorial, I will start with a question:

Which of the following medications from the SGLT2 inhibitor class have been shown to decrease cardiovascular morbidity and mortality?

#Diabetes #EndoTwitter #MedEd #MedTwitter #DM2 #T2D #CardioTwitter
2/15

Sodium glucose transporters (SGLT) in proximal tubules mediate glucose reabsorption.

How?
Na/K ATPase moves Na out & K into the cell ➡️gradient for Na to flow intracellular

SGLT uses this potential to move glucose against its gradient from the tubular fluid into the cell.
3/15

SGLT2 inhibitors block glucose reabsorption
➡️renal glucose excretion
➡️glucose levels⬇️

Because this has nothing to do with insulin, they usually don’t cause hypoglycemia or weight gain.

Actually, because of the osmotic diuresis, they decrease blood pressure & weight.
Read 15 tweets

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