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Erin C. Sanders, MSN, WHNP-BC (She/Her) Profile picture
Erin C. Sanders, MSN, WHNP-BC (She/Her)
@ErinSandersNP
Proud Mama & Wife | Nurse Practitioner & Clinical Scientist | Prev MIT, Stanford | #Disabled ♿️ | #WomxnsHealth 🧠 | Catalyst | Connector | #JusticeAccomplice
Erin C. Sanders, MSN, WHNP-BC (She/Her) Profile picture Jim McCloskey Profile picture Support #MECFS Diagnostic Biomarkers #FBMECFS Profile picture ARP Profile picture Myrne Stol (she/they) Profile picture 13 subscribed
Apr 23 • 9 tweets • 3 min read
Most dermatologists do not recommend using Neosporin d/t risk of allergic contact dermatitis. Declared the Contact Allergen of the Year for 2010 by the American Contact Dermatitis Society (ACDS). Can cause secondary dermatosis known as autosensitization.
ncbi.nlm.nih.gov/pmc/articles/P…

Screenshot tweet “Prof. Akiko Iwasaki @VirusesImmunity.•1h More than half of the human volunteers who applied Neosporin into their noses showed robust antiviral gene expression (interferon-stimulated genes) measured by nasal brush, compared to placebo controls. We believe we can Increase efficacy with higher neomycin doses. (8/)”
Screenshot tweet: “Prof. Akiko Iwasaki @VirusesImmunity OK, but does this work in humans? Collaborating with @DelaCruzMed, we ran a small randomized, double-blind, placebo-controlled trial involving healthy human volunteers, who applied OTC Neosporin (containing neomycin) (n=12) or placebo (vaseline) (n=7) twice daily into their noses with cotton swabs. (7/)” Derms recommend polysporin instead because it doesn’t contain neomycin, just polymixin & bacitracin. Would also be curious what infectious disease physicians think of prolonged use of topical antibiotics in an era of increasing antimicrobial resistance & antibiotic stewardship…
Apr 12 • 12 tweets • 4 min read
The biology of neurotypical (allistic) brains is towards maximal efficiency. Microglia literally prune redundant synapses to strengthen neural connections. This works differently in autistic folks who have many more dendritic spines & less pruning🧵
Paper: nature.com/articles/nn.27…

Screenshot of line graph showing synapse formation over time with “Dendritic spine number” on y-axis and age/life phase on x-axis. Autistic Spectrum Disorder (ASD) is in magenta. Normal is in black. Schizophrenia (SZ) is in green. And Alzheimer’s disease (AD) is in Navy. Birth is marked as a vertical dashed line. Childhood is shown in light pink. Adolescence is in light green. Adulthood is light blue. Across all disease states dendritic spine formation and synapse formation increase rapidly after birth. With ASD extending the highest. This is followed by a rapid decline during adolescence ... 2/ These brains function differently. Many folks have superior pattern recognition. It’s not fully understood why. Some areas of the brain have shown more connectivity, some less. Many variables at play and lack of diagnosis especially in underrepresented groups are significant.
Mar 15 • 11 tweets • 4 min read
This is a really interesting thread on eugenics but has some glaring omissions like the connection with the current pandemic, ongoing US taxpayer funded genocide of Palestine, or that our country was founded on the genocide of Indigenous Americans and built by enslaved Africans🧵 2/ The glaring foundation of white supremacy, colonialism, patriarchy, ableism and capitalism should also be emphasized. Nazi propaganda of “useless eaters” is particularly relevant to our current moment in justifying the mass death of disabled people (as we disable more people)
Feb 14 • 7 tweets • 3 min read
Trump may have compromised the legitimacy of the CDC as a scientific institution but it was Biden and his appointees that gutted it.

So much needless suffering is about to happen. It has *ALWAYS* been a workers rights issue. One could argue one of the largest in history.

If the people in power won’t protect themselves or their own families from infection, how little do you think they care about you and me? They prioritized “the economy” above all else.
Jan 26 • 4 tweets • 3 min read
Cool. Cool. Now do reinfections…and multiple reinfections.

Then do a follow up test the next day because of cognitive PEM.

And maybe just listen to patients. Because they’ve been saying this since 2020.
cc: @sunsopeningband @tessfalor @WesElyMD

PAPER: thelancet.com/journals/eclin…




Screenshot text: “Pre-existing psychological or neurological conditions did not differentiate patients with PCC on objective performance neither (Fig. 6B). Given that depression was the most prevalent of the pre-existing conditions here (45%, see Supplementary Materials), this result is consistent with the absence of the aforementioned relationship between depression and cognitive slowing in PCC. Does the cognitive impairment get better with time? Patients with PCC showed the reverse trend: prolonged duration of PCC was linked with more severe cognitive slowing (r= 0.21, P= 0.003, Fig. 6C...
Figure 6 in paper How did the acute COVID-19 infection affect objective performance? (A) Although hospitalised individuals, regardless of PCC status, demonstrated no difference in RT in SRT (left) or NVT (middle), they were significantly less accurate (right). N (No PCC inpatients) = 7, N (No PCC outpatients) = 56, N (PCC
Fig. 1 Patients with PCC were slower than people without PCC, including those who had previously contracted COVID-19. (A) Simple Reaction Time (SRT)
Image Computer based tests like this exist and patients can do them remotely at home. Because many patients with LC are severely disabled and just getting to a clinic is cognitively and physically exhausting.
Nov 28, 2023 • 10 tweets • 3 min read
“The @theNCI did not respond to multiple interview requests…” -@FortuneMagazine

It’s so dystopian that business magazines continue to have some of the best media coverage on COVID and longCOVID.

Oncogenic potential IS in the realm of possibility folks. And COVID is not over The discovery of Hep B Virus was an EMBARASSMENT to @theNCI exactly because of the heavily funded and largely failed *Special Virus Cancer Program* from a scientist who LEFT the NCI in the 1960s exactly because of his interdisciplinary curiosity! Work that led to the HBV vaccine.
Oct 16, 2023 • 7 tweets • 3 min read
Neurologic effects of SARS-CoV-2 transmitted among dogs. #NeuroCOVID

Kim D-H, Kim D-Y, Kim K-S, Han S-H, Go H-J, Kim J-H, et al.

@CDCgov Emerg Infect Dis. 2023 Nov. DOI: 10.3201/eid2911.230804
Original Publication Date: October 13, 2023

.

ABSTRACT 👇 wwwnc.cdc.gov/eid/article/29…
Evidence suggests that SARS-CoV-2 can induce brain pathology in humans and other hosts. In this study, we used a canine transmission model to examine histopathologic changes in the brains of dogs infected with SARS-CoV-2. We observed substantial brain pathology in SARS-CoV-2-infected dogs, particularly involving blood-brain barrier damage resembling small vessel disease, including changes in tight junction proteins, reduced laminin levels, and decreased pericyte coverage. Furthermore, we detected phosphorylated tau, a marker of neurodegenerative disease, indicating a potential link between ... “According to our results, the brains of dogs infected with SARS-CoV-2 demonstrate severe BBB disruptions and consequent SVD-like pathologic signs, including axonopathy, glial activation, and potential neurodegenerative changes even WITHOUT neurologic signs.” #Asymptommatic #MILD
Screenshot “Furthermore, activation of the astrocytes and microglial cells was maintained up to 40 dpi, even when the virus was cleared from the brain. That finding strongly suggests that the glial cells activated by SARS-CoV-2 potentially harm axons or other components of neuronal cells, even when virus is absent in the brain. That topic could be the focus of future research that requires further in vitro/in vivo studies to reveal the mechanistic link between glial activation and neuronal damage mediated by SARS-CoV-2 infection. Tau phosphorylation is the hallmark of Alzheimer's disease. T...
Screenshot “our study has value as translational research to predict neuropathologic changes in the early phase of asymptomatic SARS-CoV-2 infection in humans because we have observed the kinetic pathologic changes in the brains of dogs that did not show any neurologic signs. Compared with other animal models, dogs are genetically similar to humans and their brain structures are similar to those of humans making our extrapolation more reliable. According to our results, the brains of dogs infected with SARS-CoV-2 demonstrate severe BBB disruptions and consequent SVD-like pathologic signs, i...
Jun 13, 2023 • 42 tweets • 20 min read
1/ Fascinating new🧠#COVID study published in @ScienceAdvances

Haven't done a 🧵 like this in a while, but let’s break down what it does and doesn’t say

#SARSCoV2 infection & viral fusogens cause neuronal & glial fusion that compromises neuronal activity science.org/doi/10.1126/sc… Abstract Numerous viruses u... 2/ The authors pose the question regarding potential neuropathological mechanisms other than neuronal cell death that help viruses spread infection within the host that then leads to brain dysfunction

⚠️Brain damage can be caused without infecting neurons
doi.org/10.1002/jmv.26…
Apr 14, 2023 • 4 tweets • 2 min read
What my “exercise” looks like now…if I’m ambitious, washing the dishes or using the vacuum with ear protection. If I’m doing REALLY well, @TheAlinker.

Before nursing school, I was a Division I collegiate track captain & worked as a personal trainer.

ME is not deconditioning.

Female white athlete sprinting on curve of red track wearing a red Nike Boston University uniform with white spiked shoes. Number 55 number on stomach. Another athlete is in the background to the right with a white and black uniform. Another athletes arm is blurred in foreground on left. Crowd in the stands behind them.
Woman wearing a white hat, pink jacket, grey pants and black shoes riding a bright yellow walking bike (Alinker) facing away from the camera. A small tan dog on leash sniffing the ground. Little boy is wearing a black hat, black checkered jacket, grey pants, and black shoes while sitting on rock in front of a river in the winter time. No leaves on thr trees but leaves, dirt and frost on ground. I used to train for 3 hours 6 days a week. I could bench my bodyweight.

After I got sick, I had to UNLEARN not to just “push through” because I would literally make myself worse.

It took YEARS to unlearn and I still overdo it, because now, just trying to *live* is exercise. Woman wearing olive winter coat and pants, has green walking stick and is looking down and smiling at her son. A little boy in a green and black hat wearing a navy and orange coat, grey pants and blue shoes. There is a tan Easter basket next to him on the grass. A bird bath, bench, and fence are in the background.
Jan 19, 2023 • 12 tweets • 8 min read
Put the label on some N95s and mail them to every American family. And start finally making kid size ones.

Issue public service announcements about cleaning the air. And how doing so improves health not just against #COVID, but allergens, pollution and other pathogens. 2/ Like someone with much better graphic design skills can make a mock up #American version USA99 (with 3M or something). Press an American Bald Eagle on the nose bridge (where the maple leaf is). Put the warning on the side. Give them to EVERYONE for FREE. Require in hospitals. Children’s CAN99 respirators from Canada made by vitacore Adult CAN99 respirators from Canada made by vitacore
Jan 19, 2023 • 19 tweets • 14 min read
In 1961 the @ACSNews, @AHAScience, the National TB Association & @APHA sent a joint letter to @POTUS Kennedy asking to appoint a national commission to investigate the link between smoking and health, without wanting to threaten the freedom of the tobacco industry. 🧵 2/ He assigned this seemingly impossible task to his @SurgeonGeneral, Luther Terry. Terry appointed an expert advisory committee to summarize the links between smoking and lung cancer. Over 13 months they met for 9 sessions.

profiles.nlm.nih.gov/spotlight/nn/f…
Nov 26, 2022 • 24 tweets • 9 min read
Progesterone, contraception & chronic disease

Dovetailing off MMPs, for menstruating people, I am curious if the expected hormonal fluctuation and necessary cyclical tissue breakdown could be associated with a higher risk for barrier permeability and pathogen translocation? Graphic representation of the menstrual cycle showing ovaria 2/ Furthermore, if progesterone “PRO-Gestation” is a hormone that is able to trigger (red arrow) or prohibit the cyclical ischemia and breakdown of the endometrium to support a pregnancy, could it do that for other mucosal barriers as well?
cc: @DrJenGunter @doctorjenn @acweyand Graphic representation of the menstrual cycle showing ovaria
Nov 13, 2022 • 11 tweets • 3 min read
As a former division 1 athlete and personal trainer this fatigue is strikingly similar to when people train to complete mechanical or metabolic failure, where the body starts to utilize anaerobic energy pathways & forms of energy conservation due to rapidly depleting resources. 2/ The problem being that the energy expended to tip you into failure and even to recover from expending any energy is DISPROPORTIONATE to what would normally be required.

The body then sacrifices other resources for necessary fuel to function.

Training like this can backfire
Oct 15, 2022 • 32 tweets • 19 min read
A core mission of mine has become deconstructing the false binary fallacy of clinician vs patient that is perpetuated by both sides.

And instead making space for the many clinicians & trainees who are also patients & bring hard earned patient wisdom to their practice & science🧵 2/ Being able to translate patient experience into the language of science, medicine and healthcare, and connect worlds of expertise has tremendous value.

These often painful experiences can enrich the care and wisdom we offer to others.

When you know better, do better ♥️
Jun 3, 2022 • 27 tweets • 13 min read
I have been *waiting* for this type of extensive autopsy study to be be performed since I first learned about #COVID19. 3/2020-3/2021
N=44 autopsies; Brains = 11
Great care taken to be performed within 24 hrs of death.
None vaccinated. Prior to variants.

cc: @drjudymelinek 🧠 Image Alt text: figure shows viral RNA was detected in every brain structure/region they tested in deceased patients with #COVID19 (n=11)

Link to presentation: videocast.nih.gov/watch=45296?jw…
Feb 26, 2022 • 8 tweets • 10 min read
@ahandvanish 1/ Patients with Long Covid (also called "Post-Acute Sequelae of SARS-CoV-2" Infection or "PASC") can experience a variety of symptoms over multiple organ systems, varying in intensity and duration. #LongCovid can occur weeks to months after mild or asymptomatic acute infection, @ahandvanish 2/ as well as more severe COVID-19, sometimes overlapping with Post Intensive Care Syndrome (PICS). The most promising trials are being done in small groups. For clots/microclots @resiapretorius @dbkell in South Africa/UK and @doctorasadkhan with German/UK team.