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Felix Poppelaars Profile picture
Felix Poppelaars
@FPoppelaars
MD/PhD, Complementologist at CU Anschutz Medical Campus (USA🇺🇸) & UMC Groningen (Netherlands🇳🇱) #Nephrology #Complementbiology #Dialysis #Transplantation
Apr 5, 2023 • 11 tweets • 4 min read
I'm excited to share my latest paper in @JASN_News on #complementbiology:

"Non-Invasive Detection of iC3b/C3d Deposits in the Kidney Using a Novel Bioluminescent
Imaging Probe."
pubmed.ncbi.nlm.nih.gov/36995143/

Time for a 🧵 & #tweetorial 👇 Image 🧵(1/10): Histologic quantification of complement C3 deposits in kidney biopsies provides prognostic information in patients with:
- IgA nephropathy,
- ANCA-associated glomerulonephritis,
- Membranous nephropathy,
- Focal segmental glomerulosclerosis,
- Diabetic nephropathy.
Dec 8, 2022 • 12 tweets • 8 min read
A new milestone 🎉: my 3⃣0⃣th publication!

Published @amjtransplant, entitled:
"An interleukin 6-based genetic risk score strengthened with interleukin 10 polymorphisms associated with long-term #kidney allograft outcomes."
➡️pubmed.ncbi.nlm.nih.gov/36453708/

Time for a #tweetorial 🧵👇 Image 1.) Of all #kidney transplants, half are still lost in the first decade after #transplantation.

Using #genetics 🧬, we probed if interleukin 6 (IL-6) could be a target in kidney #transplantation to improve graft survival & if a genetic risk score could improve prognostication.