Alessandro Gozzi Profile picture
Senior scientist at Istituto Italiano di Tecnologia @IITalk. @ERC_Research grantee (#Disconn). Interested in autism and brain connectopathy 🧠🐁
16 Oct
Can we ‘see’ #autism in the brain? And is there a specific brain signature for the condition?

This is what we found by comparing brain connectivity maps across 16 mouse autism models

➡️Majestically led 👏👏👏by @Valerio_Zerbi @NCMLabETH

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Autism is diagnosed based on behavior - but is this condition associated with a specific brain signature of circuit dysfunction?
Despite decades of work, brain imaging has failed to identify such signature as we have evidence of under-connectivity...


Read 14 tweets
9 Oct
#Autism is often associated with an excess of synapses:
but how does this trait affect large-scale circuit function?

Here's what we found by modelling autism-related pruning deficits across-species🧠🐭

By @MarcoPagani1985 @mvlombardo & al.

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Postmortem investigations in idiopathic #Autism have consistently revealed an excess of excitatory synapses

Seminal work form the #Sulzer_Lab @Columbia has shown that postmortem synaptic surplus in #Autism is associated with hyperactive mTOR signalling
➡️this is a molecular pathway often dysregulated in autism and a key point of convergence of many autism-risk genes

Read 19 tweets
7 Aug
Wondering whether axonal input *drives* fMRI-based functional connectivity? Us too!

Here is what we found using #chemogenetic deconstruction of rsfMRI in the mouse🐁🐭

➡️Cortical silencing results in paradoxical fMRI overconnectivity

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Computational and empirical evidence suggest that structural and functional connectivity are robustly related

➡️ this recent review from @richardfbetzel @misicbata summarizes it all

⚠️A key prediction of structurally based models of fMRI coupling is that *inactivation* of a brain node would result in reduced rsfMRI connectivity with its targets⚠️

But is that really the case?

Read 19 tweets
15 May
**New preprint from the lab**

Regional, layer and cell-class specific connectivity of the mouse default mode network

Conceived & majestically led by @DrJigsaww @harrisjuliea @AllenInstitute

Thread covering DMN basics + implications of findings
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What is the Default Mode Network (DMN)?

👉Network identified in human PET/fMRI studies
👉Active and strongly synchronized during rest
👉Desynchronized by goal-oriented tasks
👉Encompasses associative cortices - Prefrontal, Cingulate, Retrosplenial, Parietal, Temporal

Why study the DMN?

👉Most prominent large-scale network of human brain
👉Pivotal substrate for higher-order cognitive and social functions
👉Key point of vulnerability for autism, schizophrenia, Alzhemier's and other brain disorders (seminal feature review below)

Read 13 tweets