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Michael Makris Profile picture
Michael Makris
@ProfMakris
Emeritus Professor of Haemostasis and Thrombosis in Sheffield, UK. I tweet about thrombosis, hemophilia, COVID-19, medicine, NHS & AI. Opinions are my own.
Sep 2, 2023 • 8 tweets • 2 min read
Is long COVID or brain fog due to clots? The TV/radio/newspaper news over the last 2 days reporting on a paper published in Nature Medicine, implied this is the case. But is this what the paper is about? @NatureMedicine #LongCovid 1/8tinyurl.com/2t4vdbwu What did this paper report?
They studied 1837 adults admitted to hospital with COVID pre Nov 2021. Patients had blood tests on admission (including fibrinogen and DDimer) and cognitive tests at 6 and 12 months. Only 626 patients had the tests at 12 months. 2/8
Aug 24, 2022 • 4 tweets • 2 min read
According to the article in @Nature on microclots and #longcovid the replication of the data is coming from a neuroscience group in Sheffield. I note this is unpublished work. This is an internationally important subject and I hope the authors submit a pre-print asap. 1/4 Image We need to see how reproducible the data are. The facts that the number of subjects studied are so small and also that they are finding the microclots in people who have not had #COVID19 are of significant concern. 2/4
Jan 9, 2022 • 7 tweets • 3 min read
I joined the Biomarin conference this evening. Not much more info than the press release but here are a few snippets that I learned. 1/7 Biomarin phase 3 steroid use. Number of patients who needed steroids not mentioned. No mention of steroid adverse events. They said they just completed recruitment of a study that uses prophylactic steroids. 2/7
Jan 9, 2022 • 4 tweets • 3 min read
Biomarin has just announced their year 2 phase 3 (134 patients) ValRox gene therapy in #hemophilia results. Yes on a Sunday evening! Stable and durable bleed control but the FVIII levels are falling significantly. tinyurl.com/2p92ksj8 1/4 Key questions: How many patients needed steroids, what was the variability in levels (and how many had levels <10% and <5%), how long is the response predicted to last? #hemophilia #genetherapy #ValRox 2/4
Jun 3, 2021 • 7 tweets • 2 min read
What is the incidence of VITT after 2nd AZ vaccination? The MHRA are saying 1.3 per 1 million. I say it may be a lot less and could be zero. #VITT #COVIT19 1/7 We do not know much about the 2nd dose VITT cases that the MHRA claims to have had reported to them. They are all >50 but we do not know anything else. Why do they not publish type of thrombosis, age, sex, co-morbidities, anti-PF4? 2/7
May 29, 2021 • 4 tweets • 1 min read
Health care workers and carers >18 years in the UK could get any vaccine relatively early on. Because of the Pfizer storage requirements, it was used largely in hospital vaccination sites. So in UK, hospital staff largely got Pfizer in contrast to Norway/Germany who got AZ. 1/4 In the UK this was a logistics issue since prior to March we knew nothing about VITT. Many European countries felt the efficacy data for the AZ vaccine were not strong for >65, so gave Pfizer to >65 and AZ to <65. 2/4
May 22, 2021 • 6 tweets • 2 min read
What is the risk of vaccine-induced immune thrombocytopenia and thrombosis (VITT) after a 2nd AZ vaccine dose? This is the commonest question I get at present on twitter, email and in clinic. 1/6 The information released by the MHRA (the UK regulator) two days ago on their website stated that they have had 15 cases of 2nd dose VITT after 9 million 2nd doses of the AZ vacc administered (ie 1 VITT case every 600,000 2nd doses of the AZ vaccine). tinyurl.com/s53nf2w 2/6
May 20, 2021 • 4 tweets • 2 min read
I am pro-vaccine and especially so when it comes to #COVID19. I have participated in the vaccine clinical trial and will do so again. I have had AZ x2. I believe people should be provided with all the available information to allow them to make a decision before vaccination. 1/4 Q1 to @MHRAgovuk: It is great that you provide the cases of VITT post AZ vaccine by decade of age. Please also provide the number of persons vaccinated with AZ by decade of age so the rates of VITT can be calculated. 2/4
May 22, 2020 • 5 tweets • 2 min read
Today has been the most important day in terms of high quality publications on COVID-19. Up to now amazingly 15425 manuscripts have been published in scientific journals. However 4 of the top 10 papers ever published on COVID-19 were published today. #COVIDー19 #Coronavirus 1/5 PAPER 1: The trial which was presented by Fauci on Remdesivir in COVID-19 has just been published by the New England Journal of Medicine. The benefit is modest but it is one of the very few RCTs with a positive result. tinyurl.com/y8s46vc7 2/5